Basic Medical School

Xinchun Chen
School of Basic Medical Sciences
Immunology and Pathogenic Biology
Distinguished Professor
Intro:

NAME  Xinchun Chen
POSITION TITLE  Distinguished Professor; Head, Department of Pathogen Biology; Associate Dean, School of Basic Medical Science

EDUCATION/TRAINING
Gannan Medical College, Ganzhou, China                                                Clinical Medicine
Sun-Yat-Sen university of Medical Science, Guangzhou, China   M.S.     Oncology / Virology
University of Arizona, Tucson, AZ, USA                                        Ph.D.    Microbiology & Immunology

A. Personal Statement
I have been working in the field of TB over 15 years, first as clinical physician specializing TB and subsequently also as a research scientist and director of the TB Research Division at the Shenzhen-Hong Kong Institute of Infectious Disease. My research has focused on human immunity to TB with a long-term goal of developing novel diagnostic biomarkers and/or novel candidate molecules for TB prevention or treatment. While it is our advantage to describe immunological characteristics in human TB patients, I welcome the opportunities to translate research findings from animals models to our clinical population and to “back-translate” clinical findings into animals may also lead to more predictive, targeted and interpretable animal models of various stages of TB infection and disease.

B. Positions and Honors
1992-1995 Physician, Jiangxi Xinhua Hospital
1998-2002 Attending Doctor, Dept. tuberculosis, Shenzhen Donghu Hospital
2006-2009 Associate Professor and associate Director, Shenzhen-Hong Kong Institute of Infectious Disease
2010-present Professor and associate Director, Shenzhen-Hong Kong Institute of Infectious Disease, Shenzhen Third People’s Hospital
2011-present Director, Shenzhen Key Laboratory of Infection and Immunity
2016-present Distinguished Professor, Department of Pathogen Biology, Shenzhen University School of Medicine

C. most relevant peer-reviewed Publications (* corresponding author)
1. Zhang G, Liu X, Wang W, Cai Y, Li S, Chen Q, Liao M, Zhang M, Zeng G, Zhou B, Feng CG, Chen X*.
Down-regulation of miR-20a-5p triggers cell apoptosis to facilitate mycobacterial clearance through targeting JNK2 in human macrophages. Cell Cycle. 2016 Sep 16;15(18):2527-38.
2. Jiang J, Chen X* An H, Yang B, Zhang F, Cheng X. Enhanced immune response of MAIT cells in tuberculous pleural effusions depends on cytokine signaling. Sci Rep. 2016 Sep 2;6:32320. doi: 10.1038/srep32320.
3. Cai Y, Yang Q, Liao M, Wang H, Zhang C, Nambi S, Wang W, Zhang M, Wu J, Deng G, Deng Q, Liu H, Zhou B, Jin Q, Feng CG, Sassetti CM, Wang F, Chen X*. xCT increases tuberculosis susceptibility by regulating antimicrobial function and inflammation. Oncotarget. 2016 May 24;7(21):31001-13
4. Yang Q, Xu Q, Chen Q, Li J, Zhang M, Cai Y, Liu H, Zhou Y, Deng G, Deng Q, Zhou B, Kornfeld H, Chen X*.Discriminating Active Tuberculosis from Latent Tuberculosis Infection by flow cytometric measurement of CD161-expressing T cells. Sci Rep. 2015 Dec 8;5:17918. doi: 10.1038/srep17918.
5. Torrado E, Fountain JJ, Liao M, Tighe M, Reiley WW, Lai RP, Meintjes G, Pearl JE, Chen X, Zak DE, Thompson EG, Aderem A, Ghilardi N, Solache A, McKinstry KK, Strutt TM, Wilkinson RJ, Swain SL, Cooper AM. Interleukin 27R regulates CD4+ T cell phenotype and impacts protective immunity during Mycobacterium tuberculosis infection. J Exp Med. 2015 Aug 24;212(9):1449-63.
6. Yu Y, Jin D, Hu S, Zhang Y, Zheng X, Zheng J, Liao M, Chen X, Graner M, Liu H, Jin Q. A novel tuberculosis antigen identified from human tuberculosis granulomas. Mol Cell Proteomics. 2015 Apr;14(4):1093-103.
7. Yang Q, Cai Y, Zhao W, Wu F, Zhang M, Luo K, Zhang Y, Liu H, Zhou B, Kornfeld H, Chen X*.IP-10 and MIG Are Compartmentalized at the Site of Disease during Pleural and Meningeal Tuberculosis and Are Decreased after Antituberculosis Treatment. Clin Vaccine Immunol. 2014 Dec;21(12):1635-44. doi: 10.1128/CVI.00499-14.
8. Zhang G, Zhou B, Li S, Yue J, Yang H, Wen Y, Zhan S, Wang W, Liao M, Zhang M, Zeng G, Feng CG, Sassetti CM, Chen X*. Allele-Specific Induction of IL-1b Expression by C/EBPb and PU.1 Contributes to Increased Tuberculosis Susceptibility. PLoS Pathogens, 2014 Oct 16;10(10):e1004426.
9. Ma J, Yang B, Yu S, Zhang Y, Zhang X, Lao S, Chen X, Li B, Wu C. Tuberculosis antigen-induced expression of IFN-α in tuberculosis patients inhibits production of IL-1β. FASEB J. 2014; Mar 27 [Epub ahead of print].
10. Cai Y, Yang Q, Tang Y, Zhang M, Liu H, Zhang G, Huang J, Gao Z, Zhou B, Feng CG, Chen X *. Increased complement C1q level marks active disease in human tuberculosis. PLoS One. 2014; 9(3):e92340.
11. Zhang M, Zhang G, Yang Q, Zhang J, Zhu X, Chen Q, Suthakaran P, Zhang Y, Deng, Q, Liu H, Zhou B, Chen X *. Anti-tuberculosis treatment enhances the production of IL-22 through reducing the frequencies of regulatory B cell. Tuberculosis 2014; 94:238-244.
12. Liu L, Zhang WJ, Zheng J, Fu H, Chen Q, Zhang Z, Chen X, Zhou B, Feng L, Liu H, Jin Q. xploration of novel cellular and serological antigen biomarkers in the ORFeome of Mycobacterium tuberculosis. Mol Cell Proteomics. 2014 ; 13(3) :897-906.
13. Liao M, Yang Q, Zhang J, Zhang M, Deng Q, Liu H, Garner MW, Kornfeld H, Chen X *. Gamma interferon immunospot assay of pleural effusion mononuclear cells for diagnosis of tuberculous pleurisy. Clin Vaccine Immunol. 2014; 21(3):347-353.
14. Zhang G, Zhou B, Wang W, Zhang M, Zhao Y, Wang Z, Yang L, Zhai J, Feng CG, Wang J, Chen X *. A Functional Single-Nucleotide Polymorphism in Interleukin-6 Promoter is associated with Susceptibility to Tuberculosis. J Infect Dis. 2012; 205(11):1697-704.
15. Zhang M, Zheng X, Zhang J, Zhu Z, Zhu X, Liu H, Zeng M, Graner WM, Zhou B, Chen X*. CD19+CD1d+CD5+ B Cell Frequencies Are Increased in Patients with Tuberculosis and Suppress Th17 Responses. Cell Immunol. 2012; 274(1-2):89-97.
16. Qiu Z, Zhang M,Zhu Y,Zheng F,Lu P,Liu H, Graner WM, Zhou B, Chen X *. Multifunctional CD4 T Cell Responses in Patients with Active Tuberculosis. Multifunctional CD4 T Cell Responses in Patients with Active Tuberculosis. Sci. Rep. 2012; 2( 216); DOI:10.1038/srep00216.
17. Zhang G#, Chen X#, Chan L , Zhang M1, Zhu B , Wang L, Zhu X, Zhang J, Zhou B, Wang J. An SNP selection strategy identified IL-22 associating with susceptibility to tuberculosis in Chinese. Sci. Rep. 2011,1(20); DOI:10.1038/srep00020. (#equally contributed)
18. Zhang M, Wang Z, Graner MW, Yang L, Liao M, Yang Q, Gou J, Zhu Y, Wu C, Liu H, Zhou B, Chen X*. B cell infiltration is associated with the increased IL-17 and IL-22 expression in the lungs of patients with tuberculosis. Cell Immunol. 2011; 270(2):217-23.
19. Zhang M, Wang H, Liao M, Chen X, Graner, Zhu X, Zhang J, Yang Q, Lu H, Zhou B, Chen X*. Diagnosis of Latent Tuberculosis Infection in BCG-Vaccinated subjects in China by Interferon-γ Elispot Assay. Int J Tuberc Lung Dis. 2010; 14(12):1556-63.
20. Chen X, Zhang M, Liao M, Graner, Yang Q, Wu C, Liu H, Zhou B, Reduced Th17 Response in Patients with Tuberculosis Correlate with IL-6R Expression on CD4+ T Cells. Am J Respir Crit Care Med. 2010;181(7):734-42.
21. Chen X*, Zhang M, Zhu X, Deng Q, Liu H, Larmonior N, Jin Q, Zhou B,Engagement of Toll-like Receptor 2 on CD4 T cells Facilitates Local Immune Responses In Patients With Tuberculous Pleurisy, J Infect Dis. (IF 5.68)2009;200(3):399-408
22. Chen X*, Yang Q, Zhang M, Graner M, Zhu X, Larmonior N, Liao M, Yu W, Deng Q, Zhou B. Diagnosis of Active Tuberculosis in China Using an In-House Interferon gamma Enzyme-Linked Immunospot Assay. Clin Vaccine Immunol. 2009; 16(6):879-84.
23. Chen X*, Zhou B, Li M, Deng Q, Wu X, Le X, Wu C, Larmonier N, Zhang W, Zhang H, Wang H, Katsanis, E. CD4+CD25+FoxP3+ regulatory T cells suppress Mycobacterium tuberculosis immunity in patients with active disease. Clinical Immunology, 2007; 123(1):50-59.

D. Research Support
Ongoing:
The National Science Fund for Distinguished Young Scholars (NSFC Grant No.81525016) 01/2016-12/2020
“Infection and Immunity.”
The major goal of this grant is to investigate the potential of xCT as a target for host directed therapy against TB.
Role: Principal Investigator
Direct RMB ¥4,000,000
Shenzhen Science and Technology Grant (JSGG20160427104724699) 07/2016-12/2018
Host-directed therapy against tuberculosis in patients with diabetes.
The major goal of this grant is to define and develop strategy for host directed therapy against TB in patients with
diabetes.
Role: Principal Investigator
Direct RMB ¥3,500,000
National Nature Science Foundation of China( Grant No.81273140) 01/2013-12/2016
“IL1B/TGFB/Il6/IL17A gene SNPs alter the susceptibility to tuberculosis through regulation of IL-17 expression”
The major goal of this grant is to define the host genetics control of IL-17 response in tuberculosis and its contribution to
susceptibility to human tuberculosis.
Role: Principal Investigator
Direct RMB ¥750,000

Email: chenxinchun@hotmail.com