Medical Immunology

Huang, Zhong (Professor)
School of Basic Medical Sciences
Department of Medical Immunology

NAME: Huang, Zhong


Professor of Immunology; Chair, Department of Immunology in Shenzhen University School of Medicine; Director, Institute of Biotherapy in Shenzhen University; Vice Chairman, Shenzhen Cancer Institute for Biological Treatment.

 EDUDATION/TRAINING: (Begin with baccalaureate or other initial professional education, such as nursing include postdoctoral training and residency training if applicable. )


Institution and Location


Completion Date mm/yyyy

Field of Study

Guangdong Medical University, Guangdong, China

Bachelor of Medicine



University of Oklahoma Health Science Center, OK, U.S



Cell Biology

Department of Immunology and Cancer, Oklahoma Medical Research Foundation, OK, U.S






11/08-Present        Professor , Shenzhen University School of Medicine, Shenzhen, Guangdong, China

03/09-Present         Chair, Department of Immunology in Shenzhen University School of Medicine, Shenzhen, Guangdong, China

11/10-Present        Director, Institute of Biotherapy in Shenzhen University, Shenzhen, Guangdong, China

10/12-Present        Vice Chairman, Shenzhen CancerInstitute for biological treatment, Shenzhen, Guangdong, China



My lab focuses on the study of immunoregulatory mechanisms of autoimmune diseases and tumor immunity by immunoinhibitory cytokines.

We study the functions of immunoinhibitory cytokine in the development of autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus and ankylosing, spondylitis, as well as non infection inflammatory diseases such as osteoarthritis and gout. To explore the immunoregulatory mechanisms in the inflammatory reaction of autoimmune diseases and non infection diseases, we study the role of immunomodulatory cytokines and immune homeostasis in the pathogenesis of a variety of autoimmune diseases and non infection inflammatory diseases. The purpose of our research is to provide experimental basis for prevention and new therapeutic targets for autoimmune diseases and non infection inflammatory diseases.

Cellular immunity, especially CD8+ T cells, plays an extremely important role in the killing of tumor cells; however M2 macrophages play a key role in the metastasis of tumor. We investigate immunocytokines how to regulate the immunity of T cells and macrophages, from which to study the mechanisms of tumor immunity, tumor immunotolerance, tumor immunoescape and tumor metastasis, to elaborate the immunoregulatory mechanisms of tumor, and to search the new targets for tumor therapy.


REPRESENTATIVE PUBLICANTION: (corresponding/co-corresponding author)

  1. Liang Ye and Zhong Huang*. IL-37 restrains autoimmune diseases. Oncotarget, 2015 Sep 8;6(26):21775-6.
  2. Ye L, Jiang B, Deng J, Du J, Xiong W, Guan Y, Wen Z1, Huang K, Huang Z.*,IL-37 Alleviates Rheumatoid Arthritis by Suppressing IL-17 and IL-17-Triggering Cytokine Production and Limiting Th17 Cell Proliferation. J Immunol. 2015 Jun 1;194(11):5110-5119.
  3. Chen Bingni, Huang Kunzhao, Ye Liang, Li Yanqun, Zhang Jiawei, ZhangJinshun, Fan Xinmin, Liu Xiaokai, Li Li, Sun Jinxia, Du Jing, Huang Zhong*. Interleukin-37 is increased in ankylosing spondylitis patients and associated with disease activity, Journal of Translational Medicine, 2015,13(1): 36.
  4. Ye Liang, Wen Zhongyang, Li Yanqun, Chen Bingni, Yu Ting, Liu Lanying, Zhang Jinshun, Ma Yanmei, Xiao Shuying, Ding Liping, Li Li, Huang Zhong*,Interleukin-10 attenuation of collagen-induced arthritis is associated with suppressionof interleukin-17 and retinoid-related orphan receptor γt production in macrophages and repression of classically activated macrophages. Arthritis research & therapy, 2014, 16(2): R96.
  5. Ye Liang, Ji Ling, Wen Zhongyang, Zhou Yanfei, Hu Dongsheng, Li Yanqun,Yu Ting, Chen Bingni, Zhang Jinshun, Ding Liping, Du Jing, Huang Zhong*, IL-37 inhibits the production of inflammatory cytokines in peripheral blood mononuclear cells of patients with systemic lupus erythematosus: its correlation with disease activity, Journal of translational medicine, 2014, 12(1): 69.
  6. Li Yanqun, Wang Zi, Yu Ting, Chen Bingni, Zhang Jinshun, Huang Kunzhao, Huang Zhong*, Increased expression of IL-37 in patients with Graves' disease and its contribution to suppression of proinflammatory cytokines production in peripheral blood mononuclear cells, Plos one, 2014, 9(9): e107183.
  7. Liang Ye, Ting Yu, Yanqun Li, Bingni Chen, Jinshun Zhang, Zhongyang Wen, Bo Zhang, Xiaohong Zhou, Xiaoqing Li, Feng Li, Wei Cao, Zhong Huang*, Sulforaphane Enhances the Ability of Human Retinal Pigment Epithelial Cell against Oxidative Stress, and Its Effect on Gene Expression Profile Evaluated by Microarray Analysis.Oxidative Medicine and Cellular Longevity,Volume 2013, Article ID 413024, 13 pages


RESEARCH SUPPORT (Ongoing Research Support):

  1. Project of the National Natural Science Foundation of China (NSFC) No: 81273305,

Huang, Zhong PI;      Yuan 750,000;           01/01/2013 to 12/31/2016

The role of CD1dhiCD5+B cell subsets in the pathogenesis of rheumatoid arthritis and the mechanism of its immune regulation.


  1. Shenzhen science and technology innovation research project, No:CXZZ20150930105220591,

Huang, Zhong PI;      Yuan 1,500,000;        01/01/20156to 12/31/2018 The development of drugs for the treatment of rheumatoid arthritis.


  1. Key project of basic research of science and technology plan of Shenzhen, No:JCYJ20140711144858545.

Huang, Zhong PI;      Yuan 300,000;           01/01/20156to 12/31/2018 Mechanism of molecular immune regulation of IL-37 in the immune response of rheumatoid arthritis



Tel: 0755-86671943