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【医学部学术讲座】——Hybrid Vesicular Assemblies for Cancer Imaging and Therapy

文章来源: 作者: 发布时间:2017年06月29日 点击数: 字体:

主讲嘉宾:Dr. Zhihong Nie, University of Maryland, College Park

时间: 2017年07月06日下午 14:00 – 16:00

地点: 深圳大学南校区医学院725会议室

主持人: 黄鹏 教授

Abstract:

Both inorganic and organic (or polymeric) nanoparticles (NPs) have been widely explored for therapeutic and diagnostic applications. Among others, inorganic NPs are attractive for the treatment, diagnosis, and detection of tumors, because of their unique features as compared with their organic and polymeric counterparts. For this purpose, single NPs are often used and functionalized with organic or polymeric ligands to improve their stability, biocompatibility and functionality. While single NPs are attractive, the self-assembly of NPs can yield materials with new or advanced properties that are different from their individuals. For example, the organization of gold NPs allows for tuning the absorption of NP ensembles in the near-infrared window which is highly desired for in vivo applications. The clustering of magnetic NPs within micelles dramatically increases the magnetic resonance imaging contrast and responsiveness to external magnetic field. It is, therefore, expected that the ability to design assembled structures with tailored spatial arrangement of NPs may facilitate the utilization of inorganic NPs in biomedical applications. In this talk, I will present our efforts to develop new strategies for the self-assembly of polymer-functionalized inorganic NPs into functional hybrid materials and to evaluate the hybrid assemblies for cancer imaging and treatment. Specifically, I will focus on the design and application of vesicular structures containing gold NPs, magnetic NPs or both for effective multimodality cancer imaging (i.e., photothermal, photoacoustic, and magnetic resonance imaging) and combinational cancer therapy (i.e., photothermal ablation of tumor, photodynamic therapy, and targeted delivery-based chemotherapy).

主讲嘉宾简介:

聂志鸿,2003年于中科院长春应用化学研究所安立佳研究员(中国科学院院士)指导下获得高分子物理与化学硕士学位,2008年于加拿大多伦多大学在Eugenia Kumacheva教授(加拿大皇家科学院院士)指导下获得高分子材料与化学博士学位。2008-2010年在哈佛大学George M. Whiteside教授(美国科学院院士)研究组进行NSERC博士后研究。2011年受聘为马里兰大学帕克分校化学与生物化学系终身轨道制助理教授,并于2017年初升任终身教授。曾荣获美国自然科学基金会杰出青年教授奖、美国化学会石油研究基金奖、3M公司青年教授奖、马里兰大学董事会优秀教授奖、王宽诚研究奖金、加拿大自然科学与工程研究理事会博士后奖、加拿大CAGS/UMI优秀论文奖、加拿大研究主席纳米化学奖、加拿大化学研究所优秀论文奖、中国国家优秀自费留学生奖学金等奖项。聂教授研究方向主要围绕微流控反应器、纳米粒子合成与自组装、生物成像和药物释放、流行疾病检测、生物矿化与仿生材料等。聂教授在高分子化学物理、功能纳米材料及生物纳米材料交叉学科领域取得了一系列科研成果,近几年在Science, Nature Materials (2), Nature Nanotechnology, Nature Communications (2), Angewandte Chemie International Edition (7), Journal of the American Chemical Society (13), Nano Letter, Advanced Materials等重要国际期刊发表论文80余篇。迄今论文被引用9000余次(H-index=42),平均单篇文章被引用次数高于100次,在国际会议做邀请报告90余次。近期应邀为Accounts of Chemical Research, Nano Today等杂志撰写综述或评论。聂教授有7项美国专利申请以及国外学术专著3章。十余项成果被C&EN News,Chemistry World,Science Watch, Nature,Nature Nanotechnology,Royal Society of Chemistry,Small, Lab Chip,Analytical Chemistry等科研杂志及媒体介绍。聂教授目前担任Theranostics及Scientific Reports (Nature Publishing Group)等杂志编委,并担任Nat. Chem., Nat. Nanotech., Nat. Commun., J. Am. Chem. Soc., Angew. Chem. Int. Ed., Nano Lett., ACS Nano, Adv. Mater.等30余国际学术刊物审稿人。

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