Program

Program

Scientific Program (*: selected from the submitted abstracts)

 

Oct. 27 (Friday)

10:00-20:00

Registration: Lobby, Shenzhen Sentosa Hotel-Taoyuan Branch

 

16:00-18:00

Keynote speeches: Chairs, Wei-Guo Zhu and Zhao-Qi Wang

 

Marco Foiani, IFOM, Italy

An integrated ATR, ATM and mTOR-mechanical network controlling nuclear plasticity and cell migration

 

Stephen Kowalczykowski, UC Davis, USA

Molecular functions of BRCA1, BRCA2, and RAD51-paralogs in chromosome maintenance

 

18:30-20:30

Dinner

 

Oct. 28 (Saturday)

07:30-11:00

Registration: Lobby, Auditorium no. 2, Science & Technology Building, Shenzhen University main campus

 

08:30-09:00

Opening ceremony and group photo: Wei-Guo Zhu, Yuejing Hua, Zhen Liang

 

09:00-12:00

Session 1: DNA damage signaling I

Chairs: Guoliang Xu and Zhiyuan Shen

 

9:00-9:20

Zhenkun Lou, Mayo Clinic, USA

Ubiquitination signaling and the DNA damage response

9:20-9:40

Xingzhi Xu, Shenzhen University, China

UFMylation in the DNA damage response

9:40-10:00

Xiaochun Yu, City of Hope National Medical Center, USA

PARylation and dePARylation in the DNA damage response

10:00-10:20

Daochun Kong, Peking University, China

The intra-S phase checkpoint regulates E3 ligase Brl2 and chromatin structures to stabilize stalling replication forks

 

10:20-10:50

Coffee break

 

Session 2: DNA repair I

Chairs: Zhixiong Xiao and Lee Zou

 

10:50-11:10

Gerd Pfeifer, Van Andel Institute, USA

5-methylcytosine oxidation: at the interface of epigenetics and DNA damage/repair

11:10-11:30

Guoliang Xu, Institute of Biochemistry & Cell biology, CAS, China

A new DNA modification on 5-methylcytosine

11:30-11:50

Jun Huang, Zhejiang University, China

SRAD directs replication-associated DNA double-strand breaks towards the homologous recombination repair pathway

11:50-12:10

Andor Technology, Northern Ireland

Laser-induced DNA damage and a novel spinning disk confocal living cell microscopy

 

12:10-14:00

Lunch and poster viewing

[Chairs of the Poster Award Committee: Junjie Chen and Yuejin Hua]

 

14:00-17:30

Session 3: DNA replication I

Chairs: Qing Li and Dana Branzei

 

14:00-14:20

Zou Lee, Harvard Medical School, USA

New insights into the functions of ATR in the protection of genomic integrity

14:20-14:40

Binghui Shen, City of Hope National Medical Center, USA

hDNA2 facilitates centromeric DNA replication for genome stability

14:40-15:00

Dongyi Xu, Peking University, China

RIF1 promotes stalled replication fork restart

15:00-15:20

Caixia Guo, Beijing Institute of Genomics, CAS, China

O-GlcNAcylation governs genome integrity during translesion DNA synthesis

 

15:20-15:50

Coffee break

 

Session 4: Genome instability & disease I

Chairs: Dongyi Xu and Stephen West

 

15:50-16:10

Zhixiong Xiao, Sichuan University, China

Role of p53 and p73 in DNA damage- and differentiation-induced apoptosis in mouse embryonic stem cells

16:10-16:30

Bin-bing Zhou, Shanghai Jiaotong University, China

Temporal regulation of oncogenic stress during childhood ALL relapse 

16:30-16:50

Zhongwei Zhou *, Fritz Lipmann Institute, Jena, Germany

NBS1 and NOTCH1 cooperate in neural development

16:50-17:10

Guo-Min Li, UT Southwestern Medical Center as Dallas, USA

Evidence that H3K36me3 promotes a novel mutation avoidance pathway associated with transcription

17:10-17:30

Xin Lu, Ludwig Institute for Cancer Research, UK

Regulation of p53: the cancer-causing pathogens connection

17:30-17:50

Hartmut Vodermaier, Editor of EMBO Journal

Responsibility in science publishing

 

18:30-20:30

Welcome dinner

 

Oct. 29 th , Sunday

9:00-12:00

Session 5: DNA repair II

Chairs: Bin-Bing Zhou and Binghui Shen

 

9:00-9:20

Stephen West, Francis Crick Institute, UK

Unresolved recombination intermediates lead to DNA breaks and chromosome aberrations

9:20-9:40

Qi-en Wang *, Ohio State University, USA

UV radiation-induced SUMOylation of DDB2 regulates nucleotide excision repair

9:40-10:00

Wei-Guo Zhu, Shenzhen University, China

H4K16 methylation promotes 53BP1 binding to chromatin and DNA damage repair

10:00-10:20

Lei Shi, Tianjin Medical University, China

USP7 confers genotoxic resistance of cervical cancer through stabilizing MDC1

 

10:20-10:50

Coffee break

 

Session 6: DNA replication II

Chairs: Xiaofeng Zheng and Junjie Chen

 

10:50-11:10

Dana Branzei, IFOM, Italy

Roles of the Warsaw Breakage Syndrome helicase DDX11 in safeguarding genome integrity

11:10-11:30

Qing Li, Peking University, China

Chaperone RPA during DNA replication

11:30-11:50

Zhiguo Zhang, Columbia University, USA

Checkpoint kinase Rad53 couples leading and lagging strand DNA synthesis under replication stress

11:50-12:10

Lei Li, University of Texas MD Anderson Cancer Center, USA

Fanconi anemia and complex DNA lesions

12:10-12:30

Songmin Ying, Zhejiang University, China

Mitotic repair pathways in response to replication stress

 

12:30-13:30

Lunch

 

13:30-16:30

Session 7: DNA damage signaling II

Chair: Xin Lu

 

13:30-13:50

Junjie Chen, University of Texas MD Anderson Cancer Center, USA

Protein-protein interaction networks in the DNA damage response and tumorigenesis

13:50-14:10

Xiaofeng Zheng *, Peking University, China

NEDDylation antagonizes PCNA ubiquitination and regulates the recruitment of Polymerase η in response to oxidative DNA damage

14:10-14:30

Michael Huen *, University of Hong Kong, Hong Kong

Dosage effects of RNF169 in choice of DNA double-strand break repair

 

14:30-15:00

Coffee break

 

15:00-16:40

Session 8: Genome instability & disease II

Chairs: Jun Huang and Gerd Pfeifer

 

15:00-15:20

Shunichi Takeda, Kyoto University, Japan

BRCA1 and Mre11 maintain genome integrity by eliminating abortive Topoisomerase complexes

15:20-15:40

Xin-Yuan Fu, National University of Singapore, Singapore

25 Years later: JAK-STAT Pathway to PeriGenetics and DNA Repair

15:40-16:00

Rutao Cui, Boston University, USA

DOT1L is a melanocyte lineage specific caretaker tumor suppressor

16:00-16:20

Hua Lu, Tulane University, USA

Mutant p53 gains its function via c-Myc activation upon CDK4 phosphorylation at serine 249 and consequent PIN1 binding

16:20-16:40

Chun-Long Chen*, Institut Curie, France

Replication dynamics determines common fragile site instability

16:40-17:00

Jan Hoeijmakers, Erasmus Medical Center, Netherlands

DNA damage and nutrition: impact on sustaining health, aging and longevity

 

17:00-17:15

Poster awards and closing remarks

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