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【医学部学术讲座】——Dynamic Molecular Shell of Nanomaterials for Ultra Long Blood Circulation and Cancer Therapy

文章来源: 作者: 发布时间:2017年09月01日 点击数: 字体:

主讲嘉宾:德雷塞尔大学 成昊博士

时 间:2017年09月07日(周四)上午10点-12点

地 点:深圳大学南校区医学院725会议室

主 持 人:黄鹏 教授

摘要:Drug nanocarriers have been extensively studied for cancer treatment. Despite some development, there are two major challenges in applying nanomedicines in cancer therapy. One is the short blood circulation half-life of nanocarriers as they are cleared by cells of the mononuclear phagocyte system, and the other is their low interstitial diffusion in solid tumors mainly because of the elevated density of cells and extracellular matrix (ECM). We have found that a hierarchical polyethylene glycol (PEG) shell is highly efficient in prolonging nanomaterials blood circulation times through a dynamic effect. High density PEG shell in the brush regime does not have this effect. In this talk, I will show a new mechanism in extending nanomaterials blood circulation times by elucidating how the dynamic effect affects protein adsorption on nanomaterials and nanomaterial interaction with liver cells, Based on the design of hierarchical molecular grafts, we have developed a unique enzyme conjugation strategy that embeds enzymes in hierarchical PEG shell instead of exposing enzymes to the outmost surface of nanoparticles. This strategy dramatically increased nanoparticle diffusion and accumulation in solid tumors via extended nanoparticle blood circulation time and tumor ECM degradation, leading to a highly efficient antitumor efficacy. The technology of controlling topographical structure of nanocarriers may be valuable to enhance the clinical efficacy of many drug nanocarriers.

主讲嘉宾简介:

成昊博士是美国爵硕大学材料科学与工程系助理教授,同时任生物医学工程学院的兼职助理教授。他在清华大学的化工系获得学士及硕士学位,随后在美国西北大学材料科学与工程系进行聚电解质水溶液的理论研究并获得博士学位。作为博士后,他在西北大学和麻省理工学院进行了癌症及生物材料等方面的研究。成昊教授已在PNAS, Nano Letters, ACS Nano, Advanced Materials以及Cancer Research等学术期刊发表30篇文章,参与编纂了一本学术书籍。他在细胞表面修饰及应用细胞作为药物载体的领域做出了一些原创性贡献。成昊教授现在的实验室致力于纳米材料和细胞相互作用的基础研究和免疫治疗领域的应用型研究。

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