药理学教研室

郑楷 - 讲师

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郑楷

2014年在暨南大学生命科学技术学院获得理学博士学位,于2017年深圳大学医学院博士后。现为深圳大学药学院助理教授。长期从事分子生物学与药理学的研究工作,在细胞自噬-溶酶体途径在肿瘤发生发展中的作用,以及小分子化合物抗肿瘤与抗病毒分子机理等领域取得一定成果,在国际著名期刊Autophagy, mBio等权威杂志发表SCI文章30余篇。主持有国家青年科学基金和博士后基金。

 

研究方向

  1. 细胞自噬-溶酶体与肿瘤发病机制研究;
  2. 小分子化合物抗肿瘤与抗病毒分子药理研究;
  3. 病毒感染的分子机制研究

 

主持的项目

  1. 国家自然科学青年基金:皂苷类单体抑制自噬体-溶酶体融合过程在食管癌治疗中的作用与分子机制,81603341,主持,2017.01-2020.12;
  2. 中国博士后科学基金一等资助:HDAC6在HSV-1入核运输中的作用及分子机制,2015M570726,主持,2015.05-2017.05.

 

代表性成果 * 通讯作者, # 共同第一作者)

  1. Kai Zheng #, *, Yingchun Jiang#, Chenghui Liao, Xiaopeng Hu, Yan Li, Yong Zeng, Jian Zhang, Xuli Wu, Haiqiang Wu, Lizhong Liu, Yifei Wang*, Zhendan He*. NOX2-mediated TFEB activation and vacuolization regulate lysosome-associated cell death induced by Gypenoside L, a saponin isolated from Gynostemma pentaphyllum. Journal of Agricultural and Food Chemistry, 2017, 2017, 65:6625-6637.
  2. Kai Zheng , Yan Li, Shaoxiang Wang, Xiao Wang, Chenghui Liao, Xiaopeng Hu, Long Fan, Qiangrong Kang, Yong Zeng, Xuli Wu, Haiqiang Wu, Jian Zhang*, Yifei Wang*, Zhendan He*. Inhibition of autophagosome-lysosome fusion by ginsenoside Ro via the ESR2-NCF1-ROS pathway sensitizes esophageal cancer cells to 5-fluorouracil-induced cell death via the CHEK1-mediated DNA damage checkpoint. Autophagy. 2016, 12, 1593-1613
  3. Chenghui Liao#, Kai Zheng#,*, Yan Li, Hong Xu, Qiangrong Kang, Long Fan, Xiaopeng Hu, Yong Zeng, Xiaoli Kong, Jian Zhang, Xuli Wu, Haiqiang Wu, Lizhong Liu, Xiaohua Xiao, Yifei Wang*, Zhendan He*. Gypenoside L induces autophagy-associated cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release. Oncotarget. 2016,7(30):47387-47402
  4. Kai Zheng # , Chenghui Liao#, Yan Li#, Xinmin Fan, Long Fan, Hong Xu, Qiangrong Kang, Yong Zeng, Xuli Wu, Haiqiang Wu, Lizhong Liu, Xiaohua Xiao, Jian Zhang*, Yifei Wang*, Zhendan He*. Gypenoside L, isolated from Gynostemma pentaphyllum, induces cytoplasmic vacuolation death in Hepatocellular Carcinoma Cell through ROS-mediated unfolded protein response. J Agri Food Chem. 2016, 64, 1702-1711
  5. Kai Zheng , Yangfei Xiang, Xiao Wang, Qiaoli Wang, Meigong Zhong, Shaoxiang Wang, Xiaoyan Wang, Jianglin Fan, Kaio Kitazato*, Yifei Wang*. Epidermal Growth Factor Receptor-PI3K Signaling Controls Colin Activity To Facilitate Herpes Simplex Virus 1 Entry into Neuronal Cells, mBio, 2014, 5(1):e00958-13  

 

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