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【医学部学术讲座】——Adenovirus-based oncolytic virotherapy for breast cancer

文章来源: 作者: 发布时间:2018年04月02日 点击数: 字体:

主讲嘉宾:  J Michael Mathis, PhD EdD

Professor and Chair

Department of Comparative Biomedical Sciences

School of Veterinary Medicine

Louisiana State University 

时间:     2018年4月4日上午10:00

地点:     深圳大学西丽校区A6-701

主持人:   朱卫国 教授

报告摘要:

Breast cancer is the most commonly diagnosed cancer in women under 60.  Localized breast cancer is easily treated, resulting in high survival rates.  However, treatments for advanced disease are inadequate, leading to a decrease in survival to less than 24% in the first five years.  Thus, there is a great need for new therapies capable of increasing treatment efficiency.  Oncolytic virotherapy is a promising approach employing the cytolyticfunction of viruses to kill cancer cells. Among different virus platforms, the adenovirus (Ad) is frequently used for the development of oncolytic agents, due to its systemic stability, low pathogenicity and the ability to infect a broad range of dividing and non-dividing cells. However, many cancer cells, including breast cancer, lack expression of the primary Ad receptor (the human Coxsackie and Adenovirus Receptor, hCAR) limiting infectious capacity.  If the specific binding to the cancer-specific molecule on the surface of the target cells could be engineered into oncolytic Ads (OAds), the resultant constructs would be capable of overcoming this barrier, thus realizing their therapeutic potential.  Our study engineered an Ad vector to target CXCR4, a seven-membrane spanning G-protein-coupled receptor, whose role is implicated in a wide variety of tumors, including breast cancer.  Altered expression of CXCR4 drives cancer cell migration and invasion, which has been associated with metastasis.  We provide a proof of conceptfor targeting breast cancer cells overexpressing CXCR4 through its chemokine ligand SDF-1.  We also explore further development of the retargeted OAd vector for oncolytic virotherapy by using additional approaches to enhance efficacy.  

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