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【医学部学术讲座】——Multispectral Photoacoustic Imaging of Tumor Protease Activity with a Gold Nanocage-Based Activatable Probe

文章来源: 作者: 发布时间:2018年05月16日 点击数: 字体:

主讲嘉宾: Liu Cheng, Ph.D.

   间: 20170518日下午2:00 – 5:00

   点:深圳大学西丽校区A2-517会议室

摘要:Recent research has shifted from the tumor-centered view to tumor micro-environment (TME) perspective. Thus, a few proteases in the TME have become important targets of interests. For tumor imaging, modalities have been developed into different strategies to assess protease activity with their intrinsic advantages and disadvantages. Photoacoustic imaging (PAI), which has rich imaging contrast, high spatial resolution, and clinically relevant depth of penetration, has attracted significant interests. PAI also has the advantage of unmixing the signals from different sources, including exogenous and endogenous chromophores, by relying on their intrinsic PA spectral signatures. Using activatable contrast agent is an attractive strategy, which can generate a unique signal by changing their molecular composition only when activated by targeted molecules. Nevertheless, the current strategies for in vivo protease imaging have tended to focus on the development of probe design rather than the investigation of novel imaging strategy by leveraging the PAI technique and probe. In this research, we are motivated to investigate the potential of multispectral photoacoustic imaging (PAI) to estimate the distribution of protease cleavage sites inside living tumor by using a flexible activatable photoacoustic (PA) probe model system.

主讲嘉宾简介:

LIU Cheng, Ph.D, Postdoctoral Research Fellow at Dr. SUN Lei’s multi-disciplinary lab of The Hong Kong Polytechnic University, obtained his M.Phil and Ph.D of Engineering in Biomedical Engineering from The Hong Kong Polytechnic University, Hong Kong SAR, in 2014 and 2017, respectively. His research focuses on the development of inter-disciplinary sound-light-biomaterial imaging technologies as well as the application of novel multi-modal molecular imaging strategy to investigate those key cancer biology questions (e.g., angiogenesis, tumor microenvironment). Cheng pursues fundamental advances at the interface of biomolecules and acoustic/optical effect. His main engineering methods are non-invasive imaging techniques, including (but are not limited to) optical/acoustic resolution photoacoustic imaging, ultrasound imaging, smart contrast agent/nano-probe and bio-switch/reporter. Most recently, Cheng has been presented three awards at 2017 World Molecular Imaging Congress (WMIC), Philadelphia, including Industry Selected Poster Award (FUJIFILM), Student Travel Stipend Award and Chinese Students Poster Competition Gold Award. During his M.Phil study, Cheng has also been presented Best Poster Award at 2nd International Molecular Imaging Summit (IMIS), Xiamen in 2015, Student Travel Support at IEEE International Ultrasound Symposium (IUS), Taipei in 2014 and Top Prize at Student Research Award of Hong Kong Medical and Healthcare Device Industries Association (HKMHDIA), Hong Kong in 2013. He has also been invited to give seminars in some universities and research institutions and served as the HK PolyU Student Branch Chair of IEEE Ultrasonics, Ferroelectrics, and Frequency Control (UFFC), Ultrasonics Society since 2016. In this presentation, Cheng will talk about his molecular photoacoustic imaging work which has been licensed as a U.S patent and published in the journal of Molecular Imaging & Biology (MIB).

 

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