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【医学部学术讲座】——Boramino Acid as A Theranostic Agent Unifies BNCT Precision Therapy and PET Molecular Imaging

文章来源: 作者: 发布时间:2018年06月25日 点击数: 字体:

主讲嘉宾: 刘志博教授

   间: 20180625日下午4:00-5:30

   点:深圳大学西丽校区A2-517会议室

摘要:A new class of amino acid mimics—boramino acids (BAAs)—are described here as theranostic agents for PET imaging guided BNCT cancer treatment. The structure of a BAA is identical to that of the corresponding natural amino acid, except for an exotic replacement of the carboxylate with trifluoroborate. Cellular studies demonstrate the cell uptake of BAA is strongly mediated to amino acid transporter, of which the abnormal expression is often associated with cancer. In addition, animal studies of F18 labeled BAA (18F-BAA) show high tumor-specific accumulation with PET (positron emission tomography), suggesting that BAA holds great promise for the development of new PET imaging probes and AAT-targeting boron agents for BNCT cancer therapy.

 

 

主讲嘉宾简介:

    博士生导师,北京大学化学学院特聘研究员,北大-清华生命科学联合中心研究员,北京大学博雅青年学者。入选中组部第十四批“青年千人计划”。主要从事放射化学与核药学方面的研究工作,在PET分子探针和硼药物取得了一系列的突出研究成果。为癌症与炎症的鉴别以及癌症的诊疗一体化提供了新思路。在Science Advances, Angewandte Chemie, Chemical Society Reviews, Journal of Nuclear Medicine等国际权威期刊发表SCI论文30于篇。近年来先后主持参与国家自然科学基金、科技部重大专项(青年项目),并获美国核医学和分子影像学会Michael J. Welch博士后奖 Alavi-Mandell奖,JNM Editor’s Choice Award;英属哥伦比亚大学Edward Piers Memorial Award, Boehringer Ingelheim Scholarship等奖励。

 

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