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【医学部学术讲座】——Small and long noncoding RNAs in regulation of cells

文章来源: 作者: 发布时间:2018年07月20日 点击数: 字体:

主讲嘉宾: Anindya Dutta MD, PhD

Harry F. Byrd Professor and Dept. Chair

Biochemistry and Molecular Genetics

Prof. of Pathology

University of Virginia School of Medicine

Charlottesville, VA-22908

主持人:朱卫国教授

时间:2018年7月27日上午 10 :30

地点:A6-701

摘要:

We will begin with microRNAs to introduce tRFs, tRNA derived RNA fragments, also called tsRNAs.  Our lab identified them in 2009 (1) and have gone on to show their ubiquity and at least one mechanism of action (2, 3).  There are now several databases describing these tRFs (e.g. 4) and tRFs are being implicated in many different functions (reviewed in 5).  Finally, we will turn to long noncoding RNAs (lncRNAs) important for skeletal muscle differentiation and cancer progression, focusing on two that are of particular interest to the lab, DRAIC and LINC00152 (6-8).

1) Lee, 2009, Genes & Dev.;23 :2639-49

2) Kumar, 2014, BMC Biology,12:78

3) Kuscu, 2018, RNA. 2018  doi: 10.1261/rna.066126.118

4) Kumar, 2015, NAR,  43:D141-5. doi: 10.1093/nar/gku1138

5) Kumar, 2016, Trends Biochem Sci. ;41:679-689. doi: 10.1016/j.tibs.2016.05.004

6) Sakurai, Mol Cancer Res. 2015;13:828-38

7) Reon, PLoS Med. 2016;13:e1002192. doi: 10.1371/journal.pmed.1002192

8) Reon, Mol Cancer Res, 2018, in press

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