基础医学院

杨平常
基础医学院
免疫与病原生物学
特聘教授
简介:

杨平常男,1956年8月出生,医学博士,深圳大学特聘教授、博导,深圳市过敏反应与免疫学重点实验室常务副主任、广东省标准化过敏原工程技术研究中心副主任。

毕业于山西医科大学临床医学专业,于湖南医科大学获博士学位;分别在日本医科大学、纽约西奈山医学中心和加拿大McMaster大学做博士后。2013年2月全职从加拿大回国,现任深圳大学医学院特聘教授;

1999-2013/1:在加拿大McMaster 大学病理与分子医学系,分别任副教授,助理教授和助理研究员。1987-1996,在山西医科大学,分别任助教,讲师,副教授,教授和附一院耳鼻喉科主任。

办公电话:0755-86172722

Email: pcy2356@szu.edu.cn

研究方向

粉尘螨过敏原新基因的克隆定位与蛋白结构功能分析;

食物过敏原介导自身免疫性疾病的病因、发病机理研究;

食物过敏原检测试剂盒的研制。

 

科研项目

    1,国家自然科学基金:抗原/VIP融合蛋白疫苗调节肠粘膜免疫耐受、抑制食物过敏反应的机理研究(No. 31570932),2016年1月-2019年12月;

    2,国家自然科学基金:表达TSP1 的耐受型B 细胞抑制食物过敏反应的作用机理研究(No. 81373176),2014年1月-2017年12月;

    3,加拿大国立卫生研究院:Role of gut bacterial derived peptidoglycan in the induction of immune inflammation in the intestine(No.220058),2010年9月~2013年10月;

    4,深圳市科技计划项目:A20 调控肠道免疫及抑制食物过敏反应的分子机理研究(No. JCYJ2012061317255990),2013年1月~2015年12月。

    5,深圳市科技计划项目:Gal-1/特异性抗原三联剂重建肠粘膜免疫耐受的机理和应用研究(No. JCYJ2014061317007578);2015年1月~2016年12月;

 

代表性成果

(一)论文

    1,Shi Y, Xu LZ, Peng K, Wu W, Wu R, Liu ZQ, Yang G, Geng XR, Liu J, Liu ZG, Liu Z, Yang PC. Specific immunotherapy in combination with Clostridium butyricum inhibits allergic inflammation in the mouse intestine. Sci Rep 2015; 5:17651.

    2,Yang G, Geng XR, Song JP, Wu Y, Yan H, Zhan Z, Yang L, He W, Liu ZQ, Qiu S, Liu Z, Yang PC. Insulin-like growth factor 2 enhances regulatory T-cell functions and suppresses food allergy in an experimental model. J Allergy Clin Immunol. 2014, 133(6):1702-8.e5.(IF: 11.248)

    3,Wu W, Sun M, Zhang HP, Chen T, Wu R, Liu C, Yang G, Geng XR, Feng BS, Liu ZG, Liu Z, Yang PC. Prolactin mediates psychological stress-induced dysfunction of regulatory T cells to facilitate intestinal inflammation. Gut. 2014. 63(12):1883-92.(IF: 14.66)

    4,Liu ZQ, Wu Y, Song JP, Liu X, Liu Z, Zheng PY, Yang PC. Tolerogenic CX3CR1+ B cells suppress food allergy-induced intestinal inflammation in mice. Allergy. 2013; 68: 1241-8.(IF: 6.028)

 

(二)科研成果

    1、2013年“太原市中心地区30年间两次气传致敏花粉分布影响因素及临床应用研究”获山西省科技进步一等奖(主要成员)。

 

Curriculum Vitae

Ping-Chang Yang, MD, PhD

General information:

Male, born in August 1956, Professor of Department of Immunology at Shenzhen University; Deputy director of the Shenzhen Key Laboratory of allergy and Immunology; Deputy Director of Guangdong Province standard of allergen Engineering Technology Research Center.

Education background: Graduated from Clinical Medicine at Shanxi Medical University; got doctor degree at Hunan Medical University. Fulfilled postdoctoral training at Nippon Medical University of Japan, Mount Sinai Medical Center of New York of USA and McMaster University of Canada, respectively.

Academic appointment: Associate Editor, World Journal of Gastroenterology; Deputy Editor, North American Journal of Medical Science; Editorial board member, World Journal of Immunology; Editorial board member, Scientific Reports; Editorial board member, International Journal of Clinical & Medical Allergy.

Reviewer of: NSERC, CIHR, Austria Scientific Board, NSFC, Gastroenterology, Sand J immunol, Exp Physiol, J Urol, Cytokine, BMC Cell Biol, J Neuro Res, World J Gastroenterol, North Am J Med Sci, Br J Pharmacol, Cancer Investigation, Tohoku J Exp Med, FEMS Immunol Med Microbiol, Afr J Biotechnol, J Biol Chem. Afr J Bioteck, Int J Genet Mol Biol.

Employment history:

2013-present: Professor at Shenzhen University. 1999-2013: At McMaster University, Assistant Investigator, Assistant Professor and Associate Professor, respectively. 1990-1996: At Shanxi Medical University, Lecturer, Associate Professor and Professor, Chairman of the Department of Otolaryngology.

Honors:

The New Investigator Award (2008-2013), CIHR. The Richard Hunt Award, 1997, awarded by IDRP, McMaster University. Scientific prize, title: A study of contribution of allergic rhinitis to asthma, awarded by Scientific and Technological Committee, Hunan Province, China, 1990. Fellowship from Nippon Medical School, 5 million Japanese yen, I visited Nippon Medical school with the fellowship during 1992~1993. Scientific prize: title: A survey of airborne pollen in North-West area of China, warded by Scientific and Technological Committee, Shanxi Province, China, 1992. Scientific prize, title: A novel surgical treatment for the patients with both chronic sinusitis and asthma, awarded by Scientific and Technological Committee, Hunan Province, China, 1993. Scientific prize, title: Extraction of raw antigen and clinical application, awarded by Scientific and Technological Committee, Shanxi Province, China, 1994. Scientific prize, title: Inhibition of IgE by anti-IgE antibody, awarded by Scientific and Technological Committee, Shanxi Province, China, 1995. Scientific prize, title: Purify of the extraction of antigen and clinical application, awarded by Scientific and Technological Committee, Shanxi Province, China, 1995.

Tel: 0755-86172722

Email: pcy2356@szu.edu.cn

 

Representative Research Support.

1, CIHR (#220058) $150,000.00

Title: Role of gut bacterial derived peptidoglycan in the induction of immune inflammation in the intestine

My role: PI.

2, NSERC (#371268), $125,000.00

Title: Impact on the biology of mucosal tolerance in exposure to haptenated antigens

My role: PI.

3, CIHR (#191063) $600,715.00.

Title: Role of dendritic cell in oral tolerance and food allergy

My role: PI.

4, CIHR (#177843) $300,000.00.

New Investigator Award

My role: PI.

5, National Natural Science Foundation of China. 72 CNY.

Title: Role of VIP/SIT in the regulation of intestinal allergic immunity.

My role: PI.

Representative Publications

    1,Shi Y, Xu LZ, Peng K, Wu W, Wu R, Liu ZQ, Yang G, Geng XR, Liu J, Liu ZG, Liu Z, Yang PC. Specific immunotherapy in combination with Clostridium butyricum inhibits allergic inflammation in the mouse intestine. Sci Rep 2015; 5:17651.

    2,Yang G, Geng XR, Song JP, Wu Y, Yan H, Zhan Z, Yang L, He W, Liu ZQ, Qiu S, Liu Z, Yang PC. Insulin-like growth factor 2 enhances regulatory T-cell functions and suppresses food allergy in an experimental model. J Allergy Clin Immunol. 2014, 133(6):1702-8.e5.(IF: 11.248)

    3,Wu W, Sun M, Zhang HP, Chen T, Wu R, Liu C, Yang G, Geng XR, Feng BS, Liu ZG, Liu Z, Yang PC. Prolactin mediates psychological stress-induced dysfunction of regulatory T cells to facilitate intestinal inflammation. Gut. 2014. 63(12):1883-92.(IF: 14.66)

    4,Liu ZQ, Wu Y, Song JP, Liu X, Liu Z, Zheng PY, Yang PC. Tolerogenic CX3CR1+ B cells suppress food allergy-induced intestinal inflammation in mice. Allergy. 2013; 68: 1241-8.(IF: 6.028)

    5,He SH , Chen X, Song CH, Liu ZQ, Zhou LF, Ma WJ, Zhao LD, Li TL, Tang SG, Xing Z, Yang PC*. A novel interferon lambda-mediated pathway in establishment of oral tolerance and inhibition of antigen-specific Th2 polarized gut inflammation. Gastroenterology. 2011; 141: 249-258.(IF: 16.716)