天然药物学教研室

贺震旦 - 教授

文章来源: 作者: 发布时间:2016年10月26日 点击数: 字体:

 

贺震旦─日本药学博士,日本博士后,美国共同研究学者,深圳大学医学部教授,药学院院长。

1991年留学日本,1994年获得日本国京都大学药学博士学位,在日本京都大学化学研究所和歧阜药科大学完成生物合成的博士后研究工作,曾在中国科学院昆明植物研究所国家重点实验室从事药用植物化学研究和香港中文大学从事天然产物及中药领域的研究工作。

2001年到美国伊利诺州立大学药学院,参加国际生物多样性合作研究组(ICBG),开展天然活性物质结构的研究。2003年8月,加盟香港赛马会中药研究院从事中药研究工作,被聘为资深研究员,组建中药研究实验室,并被聘为香港中医药管理委员会专家。贺震旦博士研究领域涉及:药物化学天然小分子药物中药生理活性物质基础及其构效关系研究等方面,在国内外核心专业刊物中发表120余篇学术研究论文;七项研究专利;完成两部学术专著,培养硕士生7名,博士生2名,博士后4名。

贺震旦博士2009年元月,受聘于深圳大学医学部,教授;药学院院长。

贺震旦博士现任广东省药理学会理事、广东省专业标准化技术委员会委员;2006年经深圳市科技专家委员会资格审定,被聘为深圳市项目基金评审专家。贺震旦博士为深圳市科创委国家高新技术企业评审专家、为发改委科技专家委员。贺博士被聘为广东生物医药产业技术创新联盟专家委员。2012年获得深圳大学“优秀指导教师”称号,深圳市“孔雀计划”海外高层次人才。

 


 

Zhendan He acquired his Ph.D. degree in Pharmaceutical Sciences from Kyoto University in Japan in 1994, and completed his postdoctoral training in Institute of Chemistry, Kyoto University and Gifu Pharmaceutical University in 1996. Dr. He worked on medicinal plant chemistry in the National Key Laboratory in Kunming Institute of Botany, Chinese Academy of Sciences from 1996 to 1998, and then work as the project director in Chinese University of Hong Kong till 2001.  Dr. He joined the International Cooperative Biodiversity Groups (ICBG) in 2001, and studied the structure of natural product in School of Pharmacy, University of Illinois at Chicago.  In 2003, Dr. He was appointed as the Senior Investigator in Institute of Chinese Medicine Limited, Hong Kong Jockey Club, and the expert of Chinese Medicine Council of Hong Kong. In 2009, Dr. He was appointed as the professor and Dean of School of Pharmaceutical Sciences, Shenzhen University.

Dr. He has been working on the structure and molecular mechanism of Chinese medicine and natural small molecule, and the development of novel drug. Dr. He has published over 120 papers with the total citation over 800 on natural medical chemistry, the body’s anti-infection enhancement of natural small molecule or traditional Chinese Medicine inducing endogenous anti-viral cytokine, the materal basis of active components.  Dr. He also has 7 patents, and published 2 books and the chapter.  Dr. He has supervised 7 Master students, 2 Ph.D students, and 4 postdoctoral scholars.

Dr. He is the councilman of Guangdong Pharmacological Society, and the Board Member of the Professional Standardization Technical Committee of Guangdong Province. He is also the evaluation expert of Shenzhen science and technology project, Shenzhen STIC National High and Novel Technology Enterprise Evaluation , the National Development and Reform Commission of Science and Technology Expert Committee, the Guangdong Expert Commissioner of Biological Medicine Industry Technology Innovation Alliance.  In 2012, Dr. He was awarded as the Outstanding Supervisor of Shenzhen University, and Shenzhen high level talent.

 


 

发表的部分代表学术论文

 

  1. DUAL-INDEX EVALUATION OF CHARACTER CHANGES IN PANAX GINSENG C. A. MEY STORED IN DIFFERENT CONDITIONS. C. Y. Li, D. T. W. Lau, T. T. X. Dong, J. Zhang, R. C. Y. Choi, H. Q. Wu, L. Y. Wang, R. S. Hong, S. H. Li, X. Song, T. Yu, W. W. Su, K. W. K. Tsim, Z. D. He*. Journal of Agricultural and Food Chemistry 2013, 61: 6568-73
  2. 白细胞介素类抗病毒细胞因子研究进展. 祝小红,胡小鹏,于甜,宋勋,李晨阳,苏庆宁,曾勇,李燕,李世和,贺震*. 现代免疫学 2013,33(6):522-526
  3. 干扰素及肿瘤坏死因子抗病毒作用研究进展. 于甜,胡小鹏,祝小红,宋勋,李晨阳,贺震旦*. 中国免疫学 2014, 30(3): 409-415
  4. INVESTIGATION ON INTERACTION BETWEEN LIGUPURPUROSIDE A AND PEPSIN BY SPECTROSCOPIC AND DOCKING METHODS. L. L. Shen, H. Xu, F. W. Huang, Y. Li, H. F. Xiao, Z. Yang, Z. L. Hu, Z. D. He*, Z. L. Zeng, Y. N. Li. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2015, 135: 256-63
  5. 天然小分子诱生机体抗病毒细胞因子研究. 胡小鹏,金哲,贺震旦*. 天然产物研究与开发 2015, 27: 1487-1500
  6. ANTI-INFLUENZA VIRUS EFFECTS OF CRUDE PHENYLETHANOID GLYCOSIDES ISOLATED FROM LIGUSTRUM PURPURASCENS VIA INDUCING ENDOGENOUS INTERFERON-g. X. P. Hu, M. M. Shao, S. Song, X. L. Wu, L. Qi, K. Zheng, L. Fan, C. H, Liao, C. Y. Li, J. He, Y. J. Hu, H. Q. Wu, S. H. Li, J. Zhang, F. X. Zhang, Z. D. He*. Journal of Ethnopharmacology 2016, 179: 128-136
  7. GYPENOSIDE L, ISOLATED FROM GYNOSTEMMA PENTAPHYLLUM, INDUCES CYTOPLASMIC VACUOLATION DEATH IN HEPATOCELLULAR CARCINOMA CELLS THROUGH REACTIVE-OXYGEN-SPECIES-MEDIATED UNFOLDED PROTEIN RESPONSE. Kai Zheng, Chenghui Liao, Yan Li, Xinmin Fan, Long Fan, Hong Xu, Qiangrong Kang, Yong Zeng, Xuli Wu, Haiqiang Wu, Lizhong Liu, Xiaohua Xiao, Jian Zhang, Yifei Wang, Zhendan He*. Journal of Agricultural and Food Chemistry 2016, 1702-1711
  8. CRUDE SAPONINS OF PANAX NOTOGINSENG HAVE NEUROPROTECTIVE EFFECTS TO INHIBIT PALMITATE-TRIGGERED ENDOPLASMIC RETICULUM STRESS-ASSOCIATED APOPTOSIS AND LOSS OF POSTSYNAPTIC PROTEINS IN STAUROSPORINE DIFFERENTIATED RGC-5 RETINAL GANGLION CELLS. Dandan Wang, Huazhang Zhu, Shiwei Li, Jiaming Yang, Yang Xiao, Qiangrong Kang, Chenyang Li, Yunshi Zhao, Yong Zeng, Yan Li, Jian Zhang, Zhendan He*, Ying Ying. Journal of Agricultural and Food Chemistry 2016, 1528-1539
  9. INHIBITION OF AUTOPHAGOSOME-LYSOSOME FUSION BY GINSENOSIDE Ro VIA ER-β-p47phox-ROS PATHWAY SENSITIZES ESOPHAGEAL CANCER CELLS TO 5-FLUOROURACIL-INDUCED CELL DEATH THROUGH CHK1-MEDIATED DNA DAMAGER RESPONSE. Kai Zheng, Yan Li, Shaoxiang Wang, Xiao Wang, Chenghui Liao, Xinmin Fan, Long Fan, Xiaopeng Hu,  Qiangrong Kang, Yong Zeng, Xuli Wu, Haiqiang Wu, Haitao Xiao, Jian Zhang, Yifei Wang, Zhendan He *. Autophagy2016, 12: 1593-1613
  10. GYPENOSIDE L INDUCES AUTOPHAGY-ASSOCIATED CELL DEATH IN HUMAN ESOPHAGEAL CANCER CELLS THROUGH ENDOPLASM RETICULUM STRESS-MEDIATED Ca2+ RELEASE. Chenghui Liao, Kai Zheng, Yan Li, Hong Xu, Qiangrong Kang, Long Fan, Xiaopeng Hu, Yong Zeng, Xiaoli Kong, Jian Zhang, Xuli Wu, Haiqiang Wu, Lizhong Liu, Xiaohua Xiao, Yifei Wang, Zhendan He*. ONCOTARGET JOURNAL 2016, 7(30): 47387-47402
  11. THE ANTIVIRAL EFFECTS OF ACTEOSIDE AND THE UNDERLYING IFN-g INDUCING ACTION. Xun Song, Jiang He, Hong Xu, Xiaopeng Hu, Xuli Wu, Haiqiang Wu, Lizhong Liu,  Chenghui Liao, Yong Zeng, Yan Li, Yue Hao, Chenshu Xu Jian Zhang, Hongjie Zhang, Zhen-Dan He * FOOD AND FUNCTION 2016,7(7): 3017-3030
  12. INDOLE ALKALOIDS FROM THE LEAVES OF NAUCLEA OFFICINALIS. L. Fan, Chenghui Liao, Qiangrong Kang, Kai Zheng, Yingchun Jiang, Z. D. He*. Molecules 2016, 21, 1−9
  13. DESIGN AND FABRICATION OF HYDROGEL-BASED NANOPARTICULATE SYSTEMS FOR IN VIVO DRUG DELIVERY. Wingfu Lai, Zhendan He*. Journal of Controlled Release 2016, 243, 260−282
  14. NATUREAL PRODUCTS: THE MASTER REGULATORS OF ANTIVIRAL CYTOKINES. Xun Song, Haitao Xiao, Chenghui Liao, Lu Li, Qiangrong Kang, Yingchun Jiang, Xiaopeng Hu, Kai Zheng, Long Fan, Zhendan He*. Current Organic Chemistry 2017, 21, 1805−1823
  15. NOX2-MEDIATED TFEB ACTIVATION AND VACUOLIZATION REGULATE LYSOSOME-ASSOCIATED CELL DEATH INDUCED BY GYPENOSIDE L, A SAPONIN ISOLATED FROM GYNOSTEMMA PENTAPHYLLUM. Kai Zheng, Yingchun Jiang, Chenghui Liao, Xiaopeng Hu, Yan Li, Yong Zeng, Jian Zhang, Xuli Wu, Haiqiang Wu, Lizhong Liu, Yifei Wang, Zhendan He*. Journal Agricultural and Food Chemistry 2017, 65, 6625−6637
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