Name：Chenyan Shi

Position：Assistant Professor

E-mail：shicy@szu.edu.cn

Personal Statement:

Dr. Shi received her Ph.D. in Biomedical Sciences from KU Leuven (Katholieke Universiteit Leuven) in Belgium. In 2022, Dr. Shi joined the School of Medicine at Shenzhen University as an assistant professor. Dr. Li was awarded Shenzhen peacock high-level talents.

Dr. Shi engaged in teaching and research in medical bioinformatics and infectious disease epidemiology. Her research interests include: (1) elucidating the mechanisms of host-pathogen interactions using multi-omics approaches; (2) identifying protective antigens for tuberculosis vaccine development; and (3) screening molecular markers for tuberculosis diagnosis. Dr. Shi has published over 20 SCI papers as first author or co-author in high-impact journals such as Microbiome, Journal of Experimental Medicine, and mBio. 

Research Interests:

l Host-pathogen interactions

l Tuberculosis vaccine

l Tuberculosis diagnosis

Research Projects:

1. NSFC (China) Project (82202574):  01/01/2023 to 12/31/2025  ￥300,000

2. GuangDong Basic and Applied Basic Research Foundation (2025A1515011647):  01/01/2025 to 12/31/2027 ￥100,000

Selected Peer-reviewed Publications:

1. Cai Y^#, Wang Y^#, Shi C^#, Dai Y, Li F, Xu Y, Wei C, Zhang P, Zhang J, Kong F, Deng G, Feng CG, Chen X.  Single-cell immune profiling reveals functional diversity of T cells in tuberculous pleural effusion. J Exp Med. 2022; 219(3):e20211777.

2. Mo S^#, Shi C^#, Cai Y, Xu M, Xu H, Xu Y, Zhang K, Zhang Y, Liu J, Che S, Liu X, Xing C, Long X, Chen X, Liu E. Single-cell transcriptome reveals highly complement activated microglia cells in association with pediatric tuberculous meningitis. Front Immunol, 2024, 15: 1387808.

3. Shi C, Beller L, Wang LJ, Rosas ALR, Coninck LD, Héry L, Mousson L, Pagès N, Rases J, Delang L, Vega-Rúa A, Failloux, Matthijnssens J. Bidirectional interactions between arboviruses and the bacterial and viral microbiota in Aedes aegypti and Culex quinquefasciatus. mBio 2022.

4. ShiC, Beller L, Deboutte W, Yinda CK, Delang L, Vega-Rúa A, Matthijnssens J,et al. Stable distinct core eukaryotic viromes in different mosquito species from Guadeloupe, using single mosquito viral metagenomics. Microbiome7, 121 (2019).

5. Shi C, Zhao L, Atoni E, Matthijnssens J, Xia H, Yuan Z. Stability of the Virome in Lab- and Field-Collected Aedes albopictus Mosquitoes across Different Developmental Stages and Possible Core Viruses in the Publicly Available Virome Data of Aedes Mosquitoes. mSystems. 2020;5:e00640-20.