Name：Lingzhi Yang

Position：Lecturer, M.S. Supervisor, Director of the Pharmaceutical Analysis Division

E-mail：yanglingzhi@szu.edu.cn

Personal Statement:

Dr. Lingzhi Yang is a Lecturer and Master’s Supervisor at the School of Pharmacy, Shenzhen University, where she also serves as Director of the Pharmaceutical Analysis Division and a key member of the Center for Biosensing and Nanodiagnostics. She received her B.S. and M.S. degrees from Wuhan University and a Ph.D. in Analytical Chemistry from the University of Tokyo, where she later conducted postdoctoral research. During her Ph.D., she was awarded the prestigious Japanese Government G30 Scholarship.

Her research focuses on biosensing, molecular probe development, and optogenetic analysis of cellular signaling. She applies analytical chemistry strategies to support drug discovery and precision diagnostics. Dr. Yang has led multiple national and provincial research projects and published in high-impact journals such as Analytical Chemistry, Biosensors and Bioelectronics, and Journal of Chromatography A. She is recognized as a Shenzhen Peacock Plan Talent and serves as an expert for the Guangdong Pharmaceutical Association and the Shenzhen Science and Technology Innovation Commission.

Research Interests:

Biosensing and molecular probe development

Pharmaceutical analysis and sample pretreatment techniques

Optogenetics and intracellular signaling regulationPatho-epigenetics

Research Projects:

1. Construction of protein–RNA heterodimeric probes for intracellular small molecule quantification (NSFC Youth Project, No. 22404114)

2. Spatiotemporal analysis of PIP3 production in living cells via optogenetic tools (Shenzhen Science and Technology Innovation Commission, No. 20200822212355001)

3. Evaluation and screening of PI3K inhibitors using immobilized enzyme microreactor-capillary electrophoresis (Guangdong Medical Foundation, No. A2019024)

4. Development of a capillary electrochromatography system based on PtdIns(3,4,5)P3-binding proteins for screening anti-tumor natural products (Guangdong NSFC, No. 2018A030310579)

Selected Peer-reviewed Publications:

1. Zhihao Li, Dihong Zhong, Haipeng Lin, Peiyin Li, Yongyi Li, Qingmei Huang, Lingzhi. Yang*, Xueji Zhang, In situ immobilization of covalent organic frameworks on diatomaceous earth for pipette-tip solid-phase microextraction. Journal of Chromatography A 2025, 1749.

2. Peiyin Li, Huiyang Zhang, Zhenyu Yang, Yiling Li, Manli Huang, Lingzhi. Yang*, Xueji Zhang, Rapid fluorescent nucleic acid sensing with ultra-thin gold nanosheets. Anal. Chim. Acta 2024, 1317, 342872.

3. Fan Yang, Qiqi Yang, Lingzhi. Yang*, Jinze Li, Yiyi Zhang, Huiting Lu, Haifeng Dong*, Xueji Zhang, Endogenous MicroRNA Accurate Diagnostics to Guide Photothermal Therapy. Anal. Chem. 2022, 94 (17), 6599-6606.

4. Xiaoyu. Hua, Jingjing. Fan, Lingzhi. Yang*, Jun. Wang, Yongqiang. Wen, Lei. Su*, Xueji. Zhang, Rapid detection of miRNA via development of consecutive adenines (polyA)-based electrochemical biosensors. Biosens Bioelectron 2022, 198, 113830. 

5. Lingzhi Yang, Takeaki Ozawa*, Haifeng Dong*, Xueji Zhang*, Optogenetic Control of Phosphatidylinositol (3,4,5)-Triphosphate Production by Light-Sensitive Cryptochrome Proteins on the Plasma Membrane. Chin. J. Chem . 2021, 39 (5), 1240-1246.