NAME: Jiang, Wei

POSITION TITLE: Assistant professor of Human Anatomy , Shenzhen University School of Medicine

EDUCATION/TRAINING

INSTITUTION AND LOCATION	DEGREE	Completion Date MM/YYYY	FIELD OF STUDY
Guilin Medical University, Guilin, China	B. Med	06/2009	Clinical  Medicine
Sun Yat-sen University,China	M.D.	06/2014	Human Anatomy

 

A.   Personal Statement

Jiang Wei, M ale, M . D . , Assistant Professor , Shenzhen University. In 2009, I entered the Zhongshan School of Medicine,Sun Yat-Sen University . And I studied under the famous Alzheimer's disease research expert Professor Wang Huaqiao .

My long-standing research interests fall in  the study of the pathogenesis and treatment of Alzheimer's disease (AD) . My main research direction is jatrorrhizine against mitochondrial damage and hyperphosphorylation of tau protein . It has been initially clarified that the Chinese medicine monomer jatrorrhizine exerts neuroprotective effect through anti-oxidative stress and inhibition of neuronal apoptosis induced by activation of MAPK signaling pathway, and also discusses that quercetin inhibits hyperphosphorylation of tau protein in Alzheimer's disease.

In 2013, My reseach was funded by the Doctoral Graduate Innovation Talents Development Support Project of Sun Yat-sen University. After graduating from M .D. in 2014, I went to teach in the Department of Anatomy, Medical School, Southeast University. I joined a group of renowned experts in neurodevelopmental research, Professor Zhao Chunjie of the National Outstanding Youth Fund, using genetically engineered mice to study the relationship between neurodevelopmental defects and the pathogenesis of AD. In November 2016, I  was appointed as an assistant professor by the Medical Department of Shenzhen University.

I participated in 3 projects of the National Natural Science Foundation of China as a major member, and chaired 2 natural science foundations of Guangdong Province, 1 medical research fund of Guangdong Province, 1 project of Guangdong Provincial Administration of Traditional Chinese Medicine, 1 project of Shenzhen Science and Technology Innovation Program, 1 project of Zhaoqing Science and Technology Innovation Project, and the initiation of research of young teachers of Shenzhen University 1 item, 1 teaching reform project of Guangdong Provincial Education Committee.I translated 3 textbooks and obtained 1 patent. Published 12 articles on AD related works and conferences (including 10 articles in SCI, 3 first or co-first author SCI articles, and 1 correspondence author).

 

 

B.   Positions and Honors

Positions and Employment

                                   

1 2/201 4 – 0 6 /201 5     L ecturer , Department of Anatomy , Southeast University School of Medicine ,Nanjing,China

07 /201 5 – 1 0 /201 6     Lecturer, Department of Anatomy, Zhaoqing Medical College,Zhaoqing,China

1 1/2016  – present    Assistant Professor, Department of Anatomy, Shenzhen University School of Medicine,

Shenzhen, China

 

 

 

C.   Contributions to Science ( ^#:co-first author,*: corresponding/co-corresponding author)

A full list of my publications (in a total of 17) is enclosed at the end of this document.

 

1.    Experimental Study on Jatrorrhizine Treating Alzheimer's Disease

1)This study demonstrated for the first time the neuroprotective effects of monomeric jatrorrhizine extracted from Rhizoma Coptidis on primary rat cortical neurons damaged by Aβ and its mechanism. We observed that jatrorrhizine exerted neuroprotective effects through effective antioxidation and anti-neuronal apoptosis and protection of neuronal mitochondrial function.Our reseach shows that jatrorrhizine has a good experimental therapeutic effect on AD, and has a multi-pathway, multi-target potential for the treatment of AD, while providing a theoretical basis for the development of jatrorrhizine into a multi-target AD drug.The study was published in the international authoritative magazine CNS & Neurological Disorders - Drug Targets. It is a magazine in the field of established neuropharmacology. Its initial impact factor was 14.75 (2007), and it is a journal for neuroscience and pharmacology. Peer expert evaluation is high, and has great influence in neuroscience and pharmacy fields. The paper has been cited 15 times.

Luo Tao^#, Jiang Wei^#, Kong Yan, Li Sheng, He Feng*, Xu Jie, Wang Hua-qiao*. The protective effects of Jatrorrhizine on β-amyloid (25-35)-induced neurotoxicity in rat cortical neurons. CNS & Neurological Disorders - Drug Targets (ISSN:1871-5273), 2012, 11(8),1030-1037.

 

 

 

2) This study explored for the first time the neuroprotective mechanism of the jatrorrhizine extracted from the Rhizoma Coptidis herba extracts on HT22 cells in hippocampal neurons injured by okadaic acid. This study shows that jatrorrhizine can not only exert anti-oxidation and protect mitochondria, but also can inhibit the apoptosis of mouse hippocampal neurons by inhibiting MAPK signaling pathway, and can further affect the activation transcription of nuclear factor NF-κB. This study further validated the effectiveness of jatrorrhizic multi-target anti-AD.

The journal's initial orientation was relatively high, and it was  a division 1 journal of neuroscience and pharmacology before 2012. It has a good reputation in the field of neuroscience and pharmacy. Although the division decreased with the year, it still has a great influence in the field of pharmacy and pharmacology. The total number of citations for this magazine in 2016 was 2447. I also published this work in the magazine as a co-first author in 2012 and was cited 13 times.

Jiang Wei^# , Duan Wen-Biao^#, Li Sheng, Shen Xiu-Yin, Zhou Yue, Luo Tao*, He Feng, Xu Jie, Huaqiao Wang*. Jatrorrhizine Protects Against Okadaic Acid Induced Oxidative Toxicity Through Inhibiting the Mitogen-Activated Protein Kinases Pathways in HT22 Hippocampal Neurons.CNS Neurol Disord Drug Targets. (ISSN:1871-5273), 2015, 14(10):1334-1342.

 

2.    Experimental Study on Quercetin Treating Alzheimer's Disease

 

Alzheimer's disease (AD) is a serious threat to human health. There have been no effective prevention and control measures. We have been committed to the experimental treatment of AD, this study is to investigate the experimental treatment effect of quercetin on AD.Abnormal phosphorylation of Tau protein is one of the important pathogenesis of AD. We used quercetin to treat Tau hyperphosphorylation in hippocampal neurons HT22 cells. It was observed that  quercetin protects against Okadaic Acid-induced injury via MAPK and PI3K/Akt/GSK3β signaling pathways in HT22 hippocampal neurons.

Our related results were published in PLOS One magazine. Our series of studies on quercetin suggest that quercetin exerts its anti-AD effect in vitro through antioxidative stress and inhibition of abnormal phosphorylation of Tau protein. It provides a theoretical basis for the development of quercetin as a multi-target anti-AD drug. In the 2016 Thomson Reuters JCR Division, the magazine was  Region 1 in the MUTIDISCIPLINARY SCIENCES category .In the 2011 JCR division, the magazine was Region 1 in the BIOLOGY category . The total number of citations for the journal in 2016 was 508,248 times. This article total number of citations was 6 times.

Jiang Wei ^# , Luo Tao^#, Li Sheng, Zhou Yue, Shen Xiuyin, He Feng*, Xu Jie, Wang Huaqiao*.Quercetin Protects against Okadaic Acid-Induced Injury via MAPK and PI3K/Akt/GSK3β Signaling Pathways in HT22 Hippocampal Neurons. PLOS One (eISSN-1932-6203). 2016 Apr 6;11(4):e0152371. Affiliation of the First Author: Zhongshan School of Medicine, Sun Yat-sen University.

 

D.   Research Support

Ongoing Research Support

1. Guangdong Provincial Natural Science Foundation Project(2017A030313904)    05/01/2017 to 05/01/2020

Wei Jiang, PI                                                                                                                                    ￥100,000

The role of jatrorrhizine in preventing mitochondrial damage in Alzheimer's disease model with PGC1α protein as the core

 

2. Guangdong Medical Science Research Fund(A2016618)                                     05/17/2016 to 05/17/2018

Wei Jiang, PI                                                                                                                                    ￥5,000

Mechanism of Effect of Jatrorrhizine on Mitochondrial Function Protection and Aβ Metabolism Based on HDAC4-PCG1α-IDE Signaling Pathway

 

3. Guangdong Provincial Traditional Chinese Medicine Fund Project(20162156)     04/26/2016 to 04/26/2018

Wei Jiang, PI                                                                                                                                    Set up projects but don't fund

Study on the Effect of Yanhuanglian Injection on Anti-Aβ Nerve Injury and Its Molecular Mechanism

 

4. Shenzhen Science and Technology Innovation Commission grant (JCYJ20170818142019191)                                                                                                                                                          03/31/2018 to 03/31/2020

Wei Jiang, PI                                                                                                     ￥300,000

The regulation of FoxO3a-PGC1 and the protection mechanism of mitochondria in the model of Alzheimer's disease induced by Aβ

 

5. Zhaoqing Science and Technology Innovation Commission grant(2016040308)   10/01/2016 to 06/01/2018

Wei Jiang, PI                                                                                                                                    Set up projects but don't fund

Protective effect of jatrorrhizine on TG-induced ER stress in HT22 cells and its mechanism

 

6. Teaching Reform of Teaching Guidance Committee of Medical and Health Specialty in Higher Vocational Education in Guangdong Province (201610052)                                                05/01/2016 to 05/01/2018

Wei Jiang, PI                                                                                                               ￥5,000

The Establishment and Practice of the Course "Clinical Rehabilitation Applied Anatomy" in Higher Vocational Education

 

7. NSFC regular project (31771567)                   01/01/2018 to 12/31/2021

Wei Jiang, Participant                                                                      ￥570,000

The Mechanism of Transporter Protein Granules (TRAPP) Complex II and Small G Protein Rab18 Regulating Lipid Drops in Mammalian Cells and Pathogenesis in Hepatic Fibrosis

 

8. NSFC regular project (81773939)                   01/01/2018 to 12/31/2021

Wei Jiang, Participant                                                        ￥600,000

Study on the Mechanism and Application of Chinese Herbal Medicine TCS in Promoting Mouse Hepatoma T Cell Immunotherapy

 

E.    Peer-reviewed publications ( ^# ： co-first author; *: corresponding author)

1.    Luo Tao^#, Jiang Wei^#, Kong Yan, Li Sheng, He  Feng*, Xu Jie, Wang Hua-qiao*. The protective effects of Jatrorrhizine on β-amyloid (25-35)-induced neurotoxicity in rat cortical neurons. CNS & Neurological Disorders - Drug Targets (ISSN:1871-5273), 2012, 11(8),1030-1037.

2.    Jiang Wei^#, Duan Wen-Biao^#, Li Sheng, Shen Xiu-Yin, Zhou Yue, Luo Tao*, He Feng, Xu Jie, Huaqiao Wang*. Jatrorrhizine Protects Against Okadaic Acid Induced Oxidative Toxicity Through Inhibiting the Mitogen-Activated Protein Kinases Pathways in HT22 Hippocampal Neurons.CNS Neurol Disord Drug Targets. (ISSN:1871-5273), 2015, 14(10):1334-1342.

3.   Jiang Wei^#, Luo Tao#, Li Sheng, Zhou Yue, Shen Xiuyin, He Feng*, Xu Jie, Wang Huaqiao*.Quercetin Protects against Okadaic Acid-Induced Injury via MAPK and PI3K/Akt/GSK3β Signaling Pathways in HT22 Hippocampal Neurons. PLOS One (eISSN-1932-6203). 2016 Apr 6;11(4):e0152371.

4.    Wei Jiang, Tao Luo,Sheng Li,Yue Zhou, Xiu-Yin Shen,  Jie Xu, Hua-qiao Wang*. Neuroprotective dffect of quercetin on okadaic acid induced oxidative stress in HT22 cell，Anat. Res,(ISSN：1671-0770)，2014,36(3): 234-235.

5.   Wen-Biao Duan，Xiao Chungou，Maosheng Ye，Xia Zhang，Wei Jiang*.Protective effect of berberine on okadaic acid induced HT22 cell injury，Anat. Res（ISSN：1671-0770），2016.08,38（4）：261-268.

6.   Sheng Li^#, Sheng Jiang#, Wei Jiang, Yue Zhou, Xiu-Yin  Shen, Tao Luo, Ling-Ping Kong and Hua-Qiao Wang*.  Anticancer effects of crocetin in human esophageal squamous cell  carcinoma KYSE-150 cells. Oncol Lett. (ISSN: 1792-1074). 2015 Mar;9(3):1254-1260.

7.   Yan Ding^#*, Wei Wang#,  Wei Jiang, Lihong Zhang, TingtingWang, Zhuo Li. Tophaceous gout causing thoracic spinal cord compression: case report and review of theliterature.  (ISSN:0028-3770)  neurochirurgie.

8.    Yaping Hou, Huayun Chen,Qiong He,Wei Jiang, Tao Luo, Jinhai  Duan, NanMu, Yunshao He, Huaqiao Wang *. Changes in methy-lation patterns of multiple genes from peripheral blood leucocytes of Alzheimer’s disease patients.(ISSN:1601-5215).Acta Neuropsychiatr. 2013 Apr;25(2):66-76.

9.     Yan Kong, Ling-Ping Kong^#, Tao Luo, Guang-Wu Li, Wei Jiang, Sheng Li, Yue Zhou and Hua-Qiao Wang*. The Protective Effects of Crocetin on Aβ1-42-Induced Toxicity in Ht22 Cells. CNS & Neurological Disorders - Drug Targets,(ISSN (Print): 1871-5273). 2014;13(9):1627-32.

10.   Li Y^#*, Liu C^#, Zhao Y, Hu K, Zhang J, Zeng M, Luo T, Jiang W, Wang H. Sevoflurane induces 

short-term changes in proteins in the cerebral cortices  of developing rats.Acta Anaesthesiol Scand.  (ISSN:0001-5172). 2013,Mar;57(3):380-390.

11.  Yujuan Li ^#, Fei Wang, Chuiliang Liu, Minting Zeng, Xue Han, Tao Luo,Wei Jiang, Jie Xu, Huaqiao Wang*. JNK pathway may be involved in isoflurane-induced apoptosis in the hippocampi of neonatal rats. （ISSN:0304-3940. Neuroscience Letters 545 (2013) 17-22.

12.    Yan Kong，Tao Luo，Wei Jiang，Sheng Li，Ling-ping Kong，Huaqiao Wang*.Protective effects of crocetinon PC12 cells injured by H2O2，Anat. Res，2012,34（5）：358-363。

13.    Zihai Ding，Shuwei Liu，Huaqiao Wang，Wei Jiang（Participant）.Grignard anatomy: forty-first Edition: anatomical basis for clinical practice, Shandong science and technology press，ISBN 978-7-5331-8938-9，July 2017

14.    Huaqiao Wang，Kaihua Guo，Quanan Mai，Wei Jiang（Participant），Functional Anatomy - Musculoskeletal Anatomy, Function and Palpation，Tianjin Science and Technology Translation Publishing House，ISBN 978-7-5433-3182-2，January 2013

15.  Histology and Embryology，People's Medical Publishing House，Wei Jiang(Participant)

16.  Cancer gene therapy，Guangdong Science and Technology Press，Wei Jiang(Participant)

17.   Wei Jiang，Chungou Xiao，Maosheng Ye，A static separation scaffold for cell separation，Utility model, patent authorization No. ZL 201620226895.5, the date of issue, 2016.08.17, China.