NAME: Sun, Weili

POSITION TITLE: Associate Researcher; Lecturer, Shenzhen University School of Medicine

EDUCATION/TRAINING

A.   Personal Statement

My major interest is in DNA replication and recombination. One of my major concerns is to investigate the DNA error-free repair pathway, homologous recombination, by using fission yeast as a model system. In particular, my studies concentrated on elucidating the role of Fml1 (the orthologue of the human Fanconi Anemia related protein FANCM) in replication lesion bypass and the meiotic role of Fbh1 in regulating meiotic recombination. I have also done some work to analyze the fission yeast RECQ orthologue Rqh1, including the impact of this protein on meiotic intergenic recombination and intragenic recombination, and the mitotic role of Rqh1 in double strain break repair. My approach was mainly genetic, including mitotic, meiotic recombination assays and CHEF gel analysis. I published two first-author papers in two high rank journals in the field, one of the paper has been cited more than 100 times since published. Some of the critical work leads to a paper published in Science. Compare to yeasts, less is known in mammalian system, hence, I continued to do a research project in mammalian cell lines to study the mammalian orthologs after obtaining the Grant from National Natural Science Foundation of China. The project aims to elucidate the role of FANCM in the asymmetrical segregation of stem cells.

B.   Positions and Honors

Positions and Employment

07/2012 –                   Associate Resercher, Assistant Professor, Medical School, Shenzhen University,

China.

02/2002 – 04/2004      Assistant General Manager, Research assistant, Shenzhen Kingrace Bio-tech.

10/1999 – 03/2000      Founder & Director, Research assistant, Institute of Oceanology, Chinese academy of sciences

Other Experience and Honors

1.    NSFC review panel (Biochemistry & Molecular Biology): 2016-2018

2.    Shenzhen “Talent Peacock” Award

3.    Teaching certificate of higher education, China

4.    Teaching certificate of the Department of Biochemistry, University of Oxford

5.    Clarendon scholarship, UK 2005-2008

6.    Oversea Research students (ORS) award, UK 2005-2008

7.    Department of Biochemistry scholarship, University of Oxford, UK 2005-2010

C.   Contributions to Science (*: corresponding/co-corresponding author)

1. 译著 , 孙伟力 , 沙鸥等 . 癌症基因治疗 . 广东科技出版社 . (Accepted. 2018)

2. Invited speaker, Sun W, The role of the Fanconi Animia gene FANCM in the post-replication repair pathway, BIT’s 7th Annual World DNA and Genome Day. Dalian, China (2016)

3. Invited speaker, Sun W & Yuan L, Fasciology, the beam of light in stem cell research —A digital anatomical study on meridians and collaterals provides new ideas in stem cell study,  BIT’s 8th Annual World Congress of Regenerative Medicine & Stem Cell-Korea (RMSC-2015-Republic of Korea), Korea (2015)

4. Invited speaker, Sun W, A digital anatomical study on meridians and collaterals —To interpret the essence of meridians and collaterals in a view of Fasciology, 2nd International Summit on Integrative Biology, Chicago, USA (2014)

5. Lorenz A, Osman F, Sun W, Nandi S, Steinacher R and Whitby MC. (2012) The fission yeast FANCM ortholog directs non-crossover recombination during meiosis. Science 336(6088):1585-8.

6. Sun W, Lorenz A, Osman F and Whitby MC. (2010) A failure of meiotic chromosome segregation in a fbh1∆ mutant correlates with persistent Rad51-DNA associations. Nucl Acid Res. 39(5):1718-31.

7. Sun W , Nandi S , Osman F , Ahn JS , Jakovleska J , Lorenz A , and Whitby MC .  (2008) The FANCM ortholog Fml1 promotes recombination at stalled replication forks and limits crossing over during DNA double-strand break repair. Mol Cell. 32(1):118-28. (>100 citations)

D.   Research Support

Project leader

National Natural Science Foundation of China (Grant No. 31200592)

The study of the mechanism of Fanconia Anemia gene FANCM in post replication repair.

Project participant

1. National Natural Science Foundation of China (Grant No. 81273305)

The role of CD1dhiCD5+B in rheumatoid arthritis;

2. National Natural Science Foundation of China (Grant No. 81273374)

The study of Toll-like receptor 7 in anti-tumor antigen construction and the mechanism of its anti-tumor effect;

3. National Natural Science Foundation of China (Grant No. 81272080)

The investigation of Fiber cell differentiation and regulation and the regeneration of human skin and sweat glands;

4. National Natural Science Foundation of China (Grant No. 81300028)

The molecular mechanism of BCL11B and its subfamily in targeting TGF- β /SMAD regulating Th17 in Asthma;

5. National Natural Science Foundation of China (Grant No. 81301063)

The mechanism of the variation of project striatal neurons in HD damage sensitivity.