NAME: Peng, Bin

POSITION TITLE: Assistant Professor of Cancer Cell Biology, Shenzhen University School of Medicine

EDUCATION/TRAINING

A.   Personal Statement

My research interests mainly focus on the molecular mechanisms of the DNA damage response and tumorigenesis. I graduated from Beijing Key Laboratory of DNA Damage Response in 2017. I am now an Assistant Professor in the laboratory of Professor. Xingzhi Xu that is actively exploring the molecular mechanisms of DNA damage signal transduction and genome stability. We are also exploring how reversible post-translational modifications (e.g., phosphorylation) regulate the DNA damage response and tumorigenesis.

B.   Positions and Honors

Positions and Employment

0 6/ 017 – present         Assistant Professor, Guangdong Key Laboratory for Genome Stability & Disease Prevention, Shenzhen University, Shenzhen, China

C.   Contributions to Science (*: corresponding ,#: co- first author)

A full list of my publications is enclosed at the end of this document.

1.    P hosphorylation of LSD1 promotes 53BP1 recruitment in response to DNA damage and modulates its chromatin release.

Protein post-translational modifications (e.g., phosphorylation and ubiquitination) play an import role in DNA damage response. I found that CK2-mediated phosphorylation of LSD1 (lysine-specific demethylase 1) on S131 and S137 (dephosphorylation was reversed by phosphatase WIP1) promotes RNF168-dependent recruitment of 53BP1 to the DNA damage site (2015 NAR). Phosphorylation of LSD1 at S126 by PLK1 promotes LSD1 release from chromation (2017 Cell BioScience).

1) Bin Peng , Jing Wang, Yuan Hu, Hongli Zhao, WenyaHou, Hongchang Zhao, Hailong Wang, Ji Liao, Xingzhi Xu*.2015. Modulation of LSD1 phosphorylation by CK2/WIP1 regulates RNF168-dependent 53BP1 recruitment in response to DNA damage. Nucleic Acids Research43 (12), 5936-5947

2) Bin Peng , Ruifeng Shi, Weiwei Jiang, Yue-He Ding, Meng-Qiu Dong, Wei-Guo Zhu, Xingzhi Xu*. 2017. Phosphorylation of LSD1 by PLK1 promotes its chromatin release during mitosis. Cell BioScience7:15. DOI 10.1186/s13578-017-0142-x.

2.    Development of novel derivatives of indolin anti-cancer compound

Our lab, in collaboration with Dr. Sheng-Li Cao’s lab at Capital Normal University has synthesized several novel indolin derivatives and has characterized their cytotoxicity against different cancer cells.

You-Shan Li^#, Bin Peng^#, Li Ma, Sheng-Li Cao*, Lu-Lu Bai, Chao-Rui Yang, Chong-Qing Wan, Hao-Jie Yan, Pan-Pan Ding, Zhong-Feng Li, Ji Liao, Ying-Ying Meng, Hai-Long Wang, Jing Li, Xingzhi Xu*. 2017. Synthesis, crystal structures and antitumor activity of two platinum(II) complexes with methyl hydrazinecarbodithioate derivatives of indolin-2-one. European Journal of Medicinal Chemistry127:137-146.

D.   Research Support

Ongoing Research Support

Science and Technology Foundation of Shenzhen City (JCYJ20170817095413908)     

01/01/2018 to 03/31/2020

Bin Peng, PI                                                                 ￥431,500

Mechanism analysis of congenital microcephaly gene MCPH5 encoding protein ASPM participates in the DNA damage response

E.    Peer-reviewed publications (*: corresponding author ； #: co-first author )

1.      Bin Peng, Jing Wang, Yuan Hu, Hongli Zhao, WenyaHou, Hongchang Zhao, Hailong Wang, Ji Liao, Xingzhi Xu*. 2015. Modulation of LSD1 phosphorylation by CK2/WIP1 regulates RNF168-dependent 53BP1 recruitment in response to DNA damage. Nucleic Acids Research43(12), 5936-5947

2.      Bin Peng, Ruifeng Shi, Weiwei Jiang, Yue-He Ding, Meng-Qiu Dong, Wei-Guo Zhu, Xingzhi Xu*. 2017. Phosphorylation of LSD1 by PLK1 promotes its chromatin release during mitosis. Cell BioScience7:15. DOI 10.1186/s13578-017-0142-x.

3.      You-Shan Li^#, Bin Peng^#, Li Ma, Sheng-Li Cao*, Lu-Lu Bai, Chao-Rui Yang, Chong-Qing Wan, Hao-Jie Yan, Pan-Pan Ding, Zhong-Feng Li, Ji Liao, Ying-Ying Meng, Hai-Long Wang, Jing Li, Xingzhi Xu*. 2017. Synthesis, crystal structures and antitumor activity of two platinum(II) complexes with methyl hydrazinecarbodithioate derivatives of indolin-2-one. European Journal of Medicinal Chemistry127:137-146.

4.      Wang H*, Peng B, Pandita RK, Engler DA, Matsunami RK, Xu X, Hegde PM, Butler BE, Pandita TK, Mitra S, Xu B, Hegde ML*. 2017. Aurora kinase B dependent phosphorylation of 53BP1 is required for resolving merotelic kinetochore-microtubule attachment errors during mitosis. Oncotarget2017 Mar 15. doi: 10.18632/oncotarget.16225

5.      Bo Liu, Rixin Cong, Bin Peng, Bingtao Zhu, Gelin Dou, Haiyan Ai, Xiaodong Zhang, Zhenghe Wang, Xingzhi Xu*.2014. CtIP is required for DNA damage-dependent induction of P21.Cell Cycle13, 90-95.

6.      Bingtao Zhu, ZhikaiXiahou, Heyu Zhao, Bin Peng, Hongchang Zhao, and Xingzhi Xu*. 2014. MTHFR promotes heterochromatin maintenance.  Biochemical and Biophysical Research Communications. 447, 702-706