BIOGRAPHICAL SKETCH

NAME: Luan Ping

POSITION TITLE: Chief Physician/ Professor, Medical Center, Shenzhen University Health Science Center

EDUCATION/TRAINING

1. Personal Statement

I have worked in the field of Neurology at the clinical, scientific research and educational levels for >20 years. I studied and worked at the Zhongshan Medical University Hospital and the Nanfang Hospital of Southern Medical University, and have a wealth of clinical experience relating to the diagnosis and treatment of neurological diseases. My main clinical and basic research interests are in neurodegenerative and cerebral vascular diseases. I am familiar with molecular and cellular neurobiology and neuropathology. In 2005, I visited Griffith University, Brisbane, Australia to conduct academic research. In 2008, I became a Doctor of Medicine and Director and Professor of Clinical Neurology. In January 2010, I was invited to be the High Level National Leader Talent of Shenzhen. I have presided and participated in National Key Basic Research ‘973’ Projects, Guangdong Provincial Science and Technology Plans and a Medical Science Fund Project in the Guangdong Province, Guangdong Province Traditional Chinese Medicine Project, Guangzhou Pharmaceutical And Health Project, Shenzhen Science and Technology Plan Key Basic Research Projects. I am now an independent PI at the Medical Center, Shenzhen University School of Medicine. My main achievements and high academic attainments have been in the fields of Alzheimer disease, brain, blood vessel and nerve diseases and nerve cell biology and treatment technology. I have published >20 academic papers in peer-reviewed, international journals such as the International Journal of CNS Neuroscience and Therapeutics, BioMed Research International, Evidence-Based Complementary and Alternative Medicine, the Journal of Biomaterials and Tissue Engineering.

2. Positions and Honors

Positions and Employment

07/2005 – 09/2005 Visiting Scholar, Life Science Research Center, Griffith University of Brisbane Australia, Australia

09/2005 – 12/2009 Adjunct Professor, Nanfang Hospital, Neurology department, Guangzhou, China

01/2010 – present Professor, Medical Center, Shenzhen University Health Science Center, Shenzhen, China

01/2012 – 01/2013 Visiting Scholar, Brain research center, The Chinese University of Hong Kong, Hong Kong, China

Organizing International Meetings

1. Co-organizer, 2016 International Conference on Laser Applications in Life Science (The 2nd China-Germany Biophotonics Seminar), October 15-18th, 2016, Shenzhen.

Other Experience and Honors

1. Research Fellow, the Brain Research Center, Chinese University of Hong Kong
2. Editor and Reviewer, CNS Neuroscience & Therapeutics (IF: 4.443)
3. Accredited Expert of Continuing Education, The Chinese Medical Association
4. Member of the Standing Committee, Chinese Optics and Biomedicine Society
5. Member of the Standing Committee, Guangdong Nerve and Dementia Committee
6. Member of Neurology, Chinese Medical Association
7. Chief Scientist Assistant, National "973" Project

 Contributions to Science (*: corresponding/co-corresponding author)

A full list of my publications (in a total of 17) is enclosed at the end of this document.

My research has focused on nervous system diseases in the elderly, including Alzheimer disease and Leukoaraiosis(LA). We found that excess Aβ is causative for Alzheimer disease and the net accumulation of Aβ is related to the rate of production of Aβ and to its rate of degradation. We are continuing to study the functional deficit of vacuolar-type H+-ATPase and its influence on the degradation of Aβ by microglia, to elucidate the mechanisms of lysosome-dependent autophage in the pathogenesis of AD.

4. Research Support

Ongoing Research Support

Ministry of Science and Technology of the People’s Republic of China (2015CB030055)

01/01/2015 to 31/12/2019

The early diagnosis of cerebrovascular diseases imaging                    

Ping Luan, PI                                                      $90,0000

Completed Research Support

Shenzhen key basic research project (JCYJ20120613160333560)            01/08/201 to 31/08/2015

Study on the role of V-ATPase dysfunction inducing abnormal degradation of Aβ in microglia lysosomal cells in the mechanism of AD

Ping Luan, PI                                                                                               $50,0000

Shenzhen key basic research project (JCYJ20150324140036853)           01/08/2015 to 31/08/2015

Synergic treatment of Alzheimer's disease with brain targeted nanoparticles incorporating NgR-siRNA and brain derived neurotrophic factor

Ping Luan, PI                                                                                               $30,0000

5. Peer-reviewed publications (*: corresponding author)

1. Zhanwen Wang^#, Yanping Zheng^#, Deqiang Zhao, Ziwei Zhao, Lixin Liu, Artem Pliss Feiqi Zhu, Jun Liu, Junle Qu, Ping Luan^*. Applications of fluorescence lifetime imaging in clinical medicine, J Innov Opt Health Sci, 2018; 11(1):1830001 通讯作者
2. Yanping Zheng^#, Fuxi Wang#, Deqiang Zhao, Yanqing Wang, Ziwei Zhao, Zhanwen Wang, Jun Liu, Jun Wang, Ping Luan^*. Predictive power of abnormal electroencephalogram for post-cerebral infarction depression, Neural Regen Res, 2017; 12(8): 1334~1338. 通讯作者
3. Wen-Li Fang, De-Qiang Zhao, Fei Wang, Mei Li, Sheng-Nuo Fan, Wang Liao, Yu-Qiu Zheng, Shao-Wei Liao, Song-Hua Xiao, Ping Luan*, Jun Liu*. Neurotropin'' alleviates hippocampal neuron damage through a HIF-1α/MAPK pathway, CNS Neurosci Ther, 2017; 23(5):428-437. 共同通讯
4. Mei-Qi Zeng^#, Jun-Fei Niu^#, Ping Luan, Ying Ying, Rui-Ping Pang, Qing-Ning Su, Hua-Zhang Zhu, Jing-Qiang Huang, Hu-Ju Chi, Li-Hong Zhang, Xin-Min Fan & Ou Sha^*. The Change of Nociceptive Neurons in the Rat Trigeminal Ganglia at Different Postnatal Ages, CNS Neurosci Ther,2017, 23(2): 190-193.
5. Songhua Xiao^#，Daoyou Zhou，Ping Luan，Beibei Gu，Longbao Feng，Shengnuo Fan，Wang Liao，Wenli Fang，Lianhong Yang，Enxiang Tao，Rui Guo，Jun Liu^*. Graphene quantum dots conjugated neuroprotective peptide improve learning and memory capability, Biomaterials, 2016, 106:98-110.
6. Sheng-nuoFan, BeiZhang, PingLuan, Bei-beiGu, QingWan, Xiao-yunHuang, WangLiao, JunLiu, PI3K/AKT/mTOR/p70S6K Pathway is Involved in Aβ25-35-Induced Autophagy, BioMed research international, 2015,161020.
7. ChunYang, Yi-kuanDu, Jian-binWu, JunWang*, PingLuan, Qin-laoYang,LinYuan, Fascia and Primo Vascular System, Evidence-based complementary and alternative medicine, 2015,303769
8. Wei-Ye Liu, Zhi-Bin Wang, Yue Wang, Ling-Chang Tong, Ya Li, Xin Wei, Ping Luan^*, Ling Li^*, Increasing the Permeability of the Blood-brain Barrier in Three Different Models in vivo, CNS Neuroscience & Therapeutics, 2015,21(7):568-574 共同通讯
9. ChunYang, Yi-kuanDu, JunWang^∗, PingLuan^*, Qin-laoYang, Wen-HuaHuang, LinYuan^∗，Tensile Load Down-Regulated Connective Tissue Growth Factor and TGF-β1 Expression in Rat Subcutaneous Fascia, Journal of Biomaterials and Tissue Engineering, 2015, 5(2):114-119 共同通讯
10. Jian-Bin Wu, Chun Yang, Yi-Kuan Du, Jun Wang^*, Ping Luan, Wen-Hua Huang, Qin-Lao Yang, Lin Yuan^*, Tensile Load Enhance Cell Proliferation in Rat Subcutaneous Fascia, Journal of Biomaterials and Tissue Engineering, 2015, 5(2):87-91
11. Chun Yang, Yi-Kuan Du, Jun wang^*, Ping Luan, Qin-Lao Yang, Wen-Hua Huang, Lin Yuan ^*, Transplanted adipose-derived stem cells ameliorate testicular dysfunction in a D-galactose–induced aging rat model, Journal of Cellular Physiology, 2015, 230(10):2403-2414
12. Lian-HongYang, Xiao-DongCai, Long-YuanJiang, Yan-RanLiang, Song-HuaXiao, Shu-QiongLiu, En-Xiang Tao, PingLuan, JunLiu^*, Inhibitory effect of Bcl-xL gene on toxicity induced by sodium nitroprusside in SH-SY5Y cells, CNS Neuroscience & Therapeutics, 2014, 20(4):379-381
13. Zhong-YanZhao, PingLuan^#, Shi-XiongHuang, Song-HuaXiao, JiaZhao, BeiZhang, Bei-BeiGu, Rong-Biao Pi, Jun Liu, Edaravone protects HT22 neurons from H2O2-induced apoptosis by inhibiting the MAPK signaling pathway, CNS Neuroscience & Therapeutics, 2013,19(3):163-169共同第一
14. Wai M.S.M, Luan P.^#, Jiang Y., Chan W.M., Tsui T.Y.M., Tang H.C., Lam W.P., Fan M., Yew D.T.*, Long term ketamine and ketamine plus alcohol toxicity- what can we learn from animal models? Mini Reviews in Medicinal Chemistry, 2013, 13(2): 273-279共同第一
15. PingLuan ^# , Hai-HongZhou, BeiZhang, An-MingLiu, Lian-HongYang, Xue-LingWeng, En-XiangTao, JunLiu, Basic fibroblast growth factor protects C17.2 cells from radiation-induced injury through ERK1/2, CNS Neuroscience & Therapeutics, 2012, 18(9):767-772共同第一
16. Rui-YanLu, Dan-FengLuo, Song-HuaXiao, Lian-HongYang, JiaZhao, Er-NiJi, En-XiangTao, Yi-GangXing, Feng-YingZhu, PingLuan^*, JunLiu, Kallikrein Gene Transfer Induces Angiogenesis and Further Improves Regional Cerebral Blood Flow in the Early Period After Cerebral Ischemia/Reperfusion in Rats, CNS Neuroscience & Therapeutics, 2012, 18(5):395-399共同通讯
17. FengHe, PingLuan*, RuiHe, Zhong-YanZhao, Zhi-QingSun, Feng-YuanChe, Yi-GangXing, JunLiu, Effect of Edaravoneon Aβ1−40 Induced Enhancement of Voltage-Gated Calcium Channel Current, CNS Neuroscience & Therapeutics, 2012, 18(1):89-90共同通讯