BIOGRAPHICAL SKETCH 　 　

NAME : Zhu , Yanxia 　 　

POSITION TITLE: Assistant   Professor of Stem  Cell Biology, Shenzhen University School of Medicine 　 　

EDUCATION/TRAINING   　 　

A.  Personal Statement 　 　

My  research fields include stem-cell characteristics and tissue engineering. I have  been acknowledged for elucidating the characteristics of  induced pluripotent stem cell s ,  adipose-derived stem cells, adipose tissue engineering, skin tissue engineering, cartilage tissue engineering, bone tissue engineering and intervertebral disc tissue engineering. I have published > 2 0 SCI papers, which together have been cited > 8 00 times. One of my studies that determined the characteristics of adipose-derived stem cells has been cited > 5 00 times to date. 　 　

B.  Positions and Honors 　 　

Positions and Employment 　 　

0 9 /201 3  – present Assistant Professor, Department of Cell Biology and Genetics , Shenzhen University School of Medicine, Shenzhen, China 　 　 　 　

C.  Contributions to Science  (*: corresponding/co-corresponding author) 　 　

A full list of my publications (in a total of 1 4) is enclosed at the end of this document. 　 　

D.  Research Support 　 　

Ongoing Research Support 　 　

Shenzhen Science and Technology Innovation Commission grant (JCYJ20160422090807181) 07/01/20 1 6  to 12 /30/20 18 　 　

Yanxia   Zhu , PI ￥ 3 0 0,000 　 　

T he development of skin tissue using ADSCs and cell sheet engineering 　 　

Shenzhen Science and Technology Innovation Commission grant ( JCYJ20170818100526471 ) 0 3 /01/20 1 8  to 0 3 /30/20 20 　 　

Yanxia   Zhu , PI ￥ 5 0 0,000 　 　

N ucleus  pulposus-like environment promote the  construction of nucleus  pulposus tissue by ADSCs 　 　

Medical Scientific Research Foundation of Guangdong Province   ( A2018555 ) 　 　

07/01/20 1 8  to 06/30/20 20 　 　

Yanxia   Zhu , PI ￥ 5 ,000 　 　

Adipose-derived stem cells combined with microenvironment mimic for the construction of nucleus  pulposus tissue 　 　

Completed Research Support 　 　

NSFC (China) (81301597 ) 01/01/20 14  to 12/31/20 16 　 　

Yanxia   Zhu , PI ￥ 23 0,000 　 　

iPS C as intervertebral disc disease model for the study of DDD mechanism 　 　

Scientific Research Foundation for Returned Scholars,  Finance Commission of S henzhen  Municipality 　 　

                         0 5 /01/20 15  to 12/31/20 17 　 　

Yanxia   Zhu , PI ￥ 2,70 0,000 　 　

T he application of RNA  activation and temperature responsive techniques in the construction of engineered intervertebral disc 　 　

Shenzhen Science and Technology Innovation Commission grant ( JCYJ20150525092940984) 07/01/20 1 5  to 12 /30/20 17 　 　

Yanxia   Zhu , PI ￥ 1 0 0,000 　 　

T he construction of engineered intervertebral disc 　 　

Shenzhen Science and Technology Innovation Commission grant ( JCYJ20130326110154156) 0 1 /01/20 1 3  to 12 /30/20 14 　 　

Yanxia   Zhu , PI ￥ 1 0 0,000 　 　

T he study of DDD mechanism using iPSC as model 　 　

E.  Peer-reviewed publications (*: corresponding author) 　 　

1.  Jia-Wang Liu, Ming-Yu Zhang, Yong-Ming Yan, Xiao-Yi Wei, Lu Dong, Yan-Xia Zhu *   and Yong-Xian Cheng * . Characterization of sesquiterpene dimmers from resina commiphora that promote adipose-derived stem cell proliferation and differentiation. The Journal of Organic Chemistry. 2018, (published online) 　 　

2.  Zhu Y , Liang Y, Zhu H, Lian C, Gu H, Zou X, Zhou G. Generation and Functional Characterization of Induced Pluripotent Stem Cells (iPSCs) from Human Intervertebral Disc Nucleus Pulposus Cells. Oncotarget, 2017, 8（26）： 42700-42711 　 　

3.  Zhu Y , Tan J, Zhu H, Lin G, Yin F, Wang L, Song K, Wang Y, Zhou G. Development of Kartogenin-conjugated chitosan- hyaluronic acid hydrogel for nucleus pulposus regeneration. Biomaterials Science, 2017, 5：784-791 　 　

4.  Yanxia Zhu , Xiaomin Wu, Yuhong Liang et al. Repair of cartilage defects in osteoarthritis rats with induced pluripotent stem cell derived chondrocytes. BMC Biotechnology, 2016, 16(1): 78-88. 　 　

5.  Yanxia Zhu,  Kedong Song, Siyu Jiang et al. Numerical simulation of mass transfer and three-dimensional fabrication of tissue engineered cartilages based on chitosan/gelatin hybrid hydrogel scaffold in a rotating bioreactor. Appl Biochem Biotechnol. 2016, 179（459）：1-17. 　 　

6.  Kedong Song, Liying Li, Yanxia Zhu   ( co-first author ) et al. Three-dimensional dynamic fabrication of engineered cartilage based on chitosan/gelatin hybrid hydrogel scaffold in a spinner fask with a special designed steel frame. Materials Science and Engineering. 2015, 55: 384-392. 　 　

7.  Kedong Song, Wenfeng Li, Yanxia Zhu  ( co-first author ) et al. Dynamic fabrication of tissue engineering bone substitutes based on derived cancelious bone scaffold in a spinner flask bioreactor system. Appl Biochem Biotechnol. 2014, 174(4): 1331-1343. 　 　

8.  Yanxia Zhu , Zhuxin Dong, Uchechukwu C. Wejinya, et al. Determination of Mechanical Properties of Soft Tissue Scaffolds by Atomic Force Microscopy Nanoindentation. Journal of Biomechanics. 2011, 44(13): 2356-2361. 　 　

9.  Yanxia Zhu , Tianqing Liu, Xuehu Ma, et al. Enhancement of ADSC Differentiation in Scaffolds with IGF-1 Gene Impregnation under Dynamic Microenvironment. Stem Cells and Development. 2010, 19(10): 1-10. 　 　

10.  Yanxia Zhu , Tianqing Liu, Kedong Song, et al. Adipose Tissue-derived Stem Cells Differentiated into Cardiomyocytes in Cardiac Microenvironment. Progress in Biochemistry and Biophysics. 2009, 36(4): 1-9. 　 　

11.  Yanxia Zhu , Tianqing Liu, Kedong Song, et al. ADSCs differentiated into cardiomyocytes in cardiac microenvironment. Mol Cell Biochem, 2009, 324(1-2): 117-129. 　 　

12.  Yanxia Zhu ,  Tianqing Liu, Kedong Song, et al. Ex vivo expansion of adipose tissue-derived stem cell in spinner flask. Biotechnology Journal. 2009, 4(8): 1198-1209. 　 　

13.  Yanxia Zhu , Tianqing Liu, Kedong Song, et al.Collagen-chitosan polymeric scaffolds for the in vitro expansion of human adipose tissue-derived stem cells. J Mater Sci: Mater Med, 2009, 20(3): 799-808 . 　 　

14.  Yanxia Zhu ,  Tianqing Liu, Kedong Song, et al.  Adipose-derived stem cell: a better stem cell than BMSC. Cell Biochemistry and Function, 2008, 26(6): 664-675.