NAME: Si Chen

POSITION TITLE: Lecturer of Immunology, Shenzhen University School of Medicine

EDUCATION/TRAINING

A.     Personal Statement

I am a lecturer in the Department of Immunology, Shenzhen University Health Science Center since 2010. I obtained my Ph.D from Jinan University in 2010. My general research area is the mechanisms underlying the pathogenesis of allergic and autoimmune diseases. I have been involved in various research projects sponsored by the National Science Foundation of China (NSFC) and have published five articles in peer-reviewed, international journals.

B.     Positions and Honors

Positions and Employment

0 6 /201 0 – present        Department of Immunology, School of Medicine Shenzhen University, Shenzhen, China

Other Experience and Honors

20 17 -present                      Reserve talent of the high-level professional talent plan in Shenzhen, China

C.     Research Support

NSFC (81300028)                                                 01/01/2014 to 12/31/2017

Si Chen, PI                                                            ￥230,000

Molecular mechanisms of BCL11B regulating of Th17 differentiation and its subfamilies by targeting TGF-β/SMAD pathway in asthma

Shenzhen Basic Research Project (1105060030331020)                  01/01/2012 to 12/31/2013

Si Chen, PI                                                                                                      ￥70,000

The effect and mechanism of IL-17 in allergic to eggs

D.     Peer-reviewed publications (*: corresponding author)

1.      Ch en S ^#, Chen B^#, Wen Z^#, Huang Z^*, Ye L^*. IL-33/ST2-mediated inflammation in macrophages is directly abrogated by IL-10 during rheumatoid arthritis. Yu Y^#, Chen S^#, Lu GF, Wu Y, Mo L, Liu ZQ, Zheng PY, Liu Z, Yang PC*. Alphavbeta6 is required in maintaining the intestinal epithelial barrier function, Cell Biol Int, 2014, 38(6): 777-781.

3.      Chen S , Huang X, Chen S, Si Chen, Yang L, Shen Q, Zheng H, Li B, Grabarczyk P, Przybylski GK, Schmidt CA, Li Y^*. The role of BCL11B in regulating the proliferation of human naïve T cells, Hum Immunol, 2012, 73(5): 456-464.

4.      Huang X^#, Chen S^#, Shen Q^#, Chen S, Yang L, Grabarczyk P, Przybylski GK, Schmidt CA, Li Y^*. Down regulation of BCL11B expression inhibits proliferation and induces apoptosis in malignant T cells by BCL11B-935-siRNA, Hematology, 2011, 16(4): 236-242.

5.      Chen S, Yang L, Chen S, Li Y^*. TCR ζ chain expression in T cells from patients with CML, Hematology, 2009, 14(2): 95-100.