NAME: Li, Lingyun

POSITION TITLE: Vice Professor of department of immunology, Shenzhen University School of Medicine

EDUCATION/TRAINING

1.    Personal Statement

Dr. Li Lingyun has been engaged in the research of molecular biology and molecular virology. During study in Osaka University, Japan, Dr. Li  focused on measles virus and cellular receptors, and then did research on the molecular mechanism of hepatitis B virus and hepatocellular carcinoma in Stanford University, USA. After back to China and join the research center, research field is the molecular mechanism of major diseases, molecular diagnosis of diseases and developmen of recombinant drugs. Dr.Li applied and received government grants of National Natural Science Foundation of China, science and technology project of Shenzhen, Published a high level Academic papers and obtained patents.

2.    Positions and Honors

Positions and Employment

07/1992– 05 /199 9     lecturer, College of Life Sciences, Wuhan University, Hubei, China

0 6 / 1999 – 05 / 2005     Vice Professor, College of Life Sciences, Wuhan University, Hubei, China

10/2006 – till now       Vice Professor, Shenzhen University School of Medicine, Shenzhen  University, Guangdong, China

3.    Contributions to Science (*: corresponding/co-corresponding author)

1.    Xu J, Lian W, Jia Y, Li L, Huang Z.Optimized guide RNA structure for genome editing via Cas9, an style=" text-decoration-line:none;"="">Oncotarget, 2017,8(17):29442-29457.

4.    Ying Ying,Lingyun Li, Wen Cao,Dan Yan,Qing Zeng,Xiangchen Kong,Lina Lu,Meng Yan,Xiaohui Xu,Junle Qu,Qingning Su*, Xiaosong Ma*.The microtubule associated protein syntabulin is required for glucose-stimulated and cAMP-potentiated insulin secretion, FEBS Lett., 2012,586(20),pp3674-80.

5.    Li L, Qi Y*. A novel amino acid position in hemagglutinin glycoprotein of measles virus is responsible for hemadsorption and CD46 binding. Arch Virol, 2002,147(4),pp775-786.

6.    Zhang P, Li L, Hu C, Xu Q, Liu X, Qi Y*. Interactions among measles virus hemagglutinin, fusion protein and cell receptor signaling lymphocyte activation molecule (SLAM) indicating a new fusion-trimer model. J Biochem Mol Biol.,2005,38(4):pp373-380.

7.    Chen M, Li LY, Qi YP*. Bcl10 protein can act as a transcription activator in yeast. Mol Cell Biochem.,2003,246(1-2),pp97-103

8.    China Invention Patent: natriuretic peptide, preparation method and application   in preparing engineering medicine, patent number: ZL201210529925.6, Jan.2016 authorization

9.    China Invention Patent: antibody screening and preparation method based on the heavy /light chain Library of the infectious virus particle. patent number：ZL201310277207.9，Jan.2016 authorization

4.    Research Support

1. Study on the expression profile of Aedes Aedes based on vector Early monitoring of the outbreak of dengue fever. 2018,01-2021,12, Project director
2. Study on the second cellular receptor of measles virus（39970032），NSFC, 2000，01-2002，12，Project director
3. Construction virus vector deleting of apoptosis inhibiting gene and Study on gene therapy（20005004024）. Youth Science and technology Chenguang Fund, Wuhan（20005004024），2000，09-2002，12，Project director
4. Analysis of genetic correlation between dengue virus and Aedes host，Reasearch on   spread mechanism of dengue virus.(JCY20150324140036829），2015,8-2017,8, Project director
5. Research on syntabulin—cross-linker protein between mitochondria and microtubules (JC201005280548A), Science and technology project (Research), Shenzhen,2011,3-2014,2 Project director.
6. Screening and functional study of novel natriuretic peptides. (JC200903120021A), Science and technology project (Research), Shenzhen, 2009,06-2012,12 Project director.
7. Research and Application of chromogenic in situ hybridization (CISH) in detection of virus associated diseases (200711), Science and technology project, Shenzhen, 2008,01-2009,12,Project director.
8. Establishment a new cell model to study the interaction mechanism of natriuretic peptide and receptor, Shenzhen university research fund.2008,01-2009,12 Project director  .
9. The regulation of mitochondrial fusion and neurodegenerative diseases by  Syntabulin(31371358）, NSFC,2014,01-2017,12, major investigator .
10. Study on apoptosis mechanism of a novel human apoptosis gene asyip（30170455）, NSFC, 2002,01-2004,12, major investigator.
11. The role of syntabulin in neurons and the development of neurodegeneration diseases（CXZD1026）, High school science and technology innovation key project, Guangdong Province , 2011,03-2014,02, major investigator.
12. Rapid test kit detecting HCV antibody and core antigen (2008A030201025), Science and technology project, Guangdong Province. 2009,01-2010,12, major investigator .