BIOGRAPHICAL SKETCH 　 　

NAME:  Yang, Pingchang 　 　

POSITION TITLE: Professor of Immunology 　 　

EDUCATION/TRAINING   　 　

 

INSTITUTION AND LOCATION	DEGREE 　 　 (if applicable)	Completion Date 　 　 MM/YYYY	FIELD OF STUDY
Shanxi Medical University, Taiyuan, China	B. Med	07/1983	Medicine
Shanxi Medical University, Taiyuan, China	M.Sc.	07/1986	Medicine
Hunan Medical University, Changsha, China	Ph.D.	07/1990	Medicine
Nippon Medical University, Tokyo, Japan	Postdoctoral	06/1993	Allergy
Mount Sinai Medical Center, New York, USA 　 　 Dept of Pathology, McMaster University, Canada	Postdoctoral 　 　 Postdoctoral	12/1996 　 　 11/1999	Allergy 　 　 Immunology

　 　

A.  Personal Statement 　 　

With the long-term goal to elucidate the pathogenesis of allergy, my research focuses on the establishment, maintenance and restoration of immune tolerance. Specifically, the development of regulatory T cells (Treg) and B cells (Breg) was investigated. The role of Tregs and Bregs in the maintenance of immune homeostasis was studied in several study projects. The restoration of immune tolerance in animal models with intestinal inflammation was investigated. I also have 8-year experience of PBL teaching at McMaster University.

B.  Positions and Honors 　 　

Positions and Employment 　 　

08/1986–09/1987 Resident, Department of Otolaryngology, Shanxi Medical University, Taiyuan, China 　 　

08/1991-02/1996 Lecturer (1990), associate professor (1991), professor (1994), Department of Otolaryngology, Shanxi Medical University, Taiyuan, China. 　 　

12/1999 –09/2004 Research Scientist, Department of Pathology, Molecular Medicine, McMaster University, Hamilton, ON, Canada. 　 　

10/2004-09/2010 Assistant professor, Department of Pathology, Molecular Medicine, McMaster University, Hamilton, ON, Canada 　 　

10/2010-01/2013 Associate professor, Department of Pathology, Molecular Medicine, McMaster University, Hamilton, ON, Canada 　 　

02/2013-present Professor, the Research Center of Allergy & Immunology, Shenzhen University, Shenzhen, China

Honors:

• The New Investigator Award (2008-2013), CIHR, Canada .
• The Richard Hunt Award , 1997, awarded by IDRP, McMaster University.
• Scientific prize, title : A study of contribution of allergic rhinitis to asthma , awarded by Scientific and Technological Committee, Hunan Province, China, 1990.
• Fellowship from Nippon Medical School, 5 million Japanese yen, I visited Nippon Medical school with the fellowship during 1992~1993.
• Scientific prize : title: A survey of airborne pollen in North-West area of China , awarded by Scientific and Technological Committee, Shanxi Province, China, 1992.
• Scientific prize , title: A novel surgical treatment for the patients with both chronic sinusitis and asthma , awarded by Scientific and Technological Committee, Hunan Province, China, 1993.
• Scientific prize , title: Extraction of raw antigen and clinical application , awarded by Scientific and Technological Committee, Shanxi Province, China, 1994.
• Scientific prize , title: Inhibition of IgE by anti-IgE antibody , awarded by Scientific and Technological Committee, Shanxi Province, China, 1995.
• Scientific prize , title: Purify of the extraction of antigen and clinical application , awarded by Scientific and Technological Committee, Shanxi Province, China, 1995.

C.  Contributions to Science   　 　

        (1) Investigation into the regulation of immune tolerance during allergic response; the major finding include: Foxp3-producing dendritic cells play am important role in the inhibition of allergic response ( Allergy . 2017;72:908-917) ;  Gal-1 extends the therapeutic effect of specific immunotherapy ( Allergy . 2018 Jan;73 (1):   106-114 ); VitD receptor plays an important role in stabilization of mast cells ( Allergy . 2017;72:1184-1192); combination of immunotherapy and butyrate-producing probiotics generate regulatory B cells ( Oncotarget ; 2016; 7:54360-54369) and TGF-β-producing monocytes (J Innate Immun. 2015;7:601-11); TSP1 has immune regulatory function ( J Biol Chem  2015; 290: 12858-67； Sci Rep . 2014; 3: 3345； J Innate Immunity  2015; 7: 601-11 ) ;  insolin-like factors can regulate immune function and contribute to immune tolerance ( J Biol Chem . 2014; 289:17941-50； J Allergy Clin Immunol  2014; 133: 1702-1708); TIM4， l -interferon play a role in the immune regulation in the intestine ( Gastroenterology . 2007;133:1522-33. Gastroenterology . 2011;141:249-58); CD23 has regulatory function on intestinal epithelial barrier function ( J Clin Invest . 2000;106:879-86. Gastroenterology . 2001;121:370-81)。 　 　

        (2) Elucidation of the role of several miRNAs in the regulation of immune cell functions ( Cell Biochem Funct  2016; 34(6):449-54. Am J Trasnl Res  2016; 8 (5): 2317-24. Sci Rep . 2015; 5: 15937. Oncotarget . 2017 Feb 21;8(8):13214-13222). 　 　

        (3) Combination of butyrate-producing probiotics and specific immunotherapy obtained better results in the inhibition of allergic disorders in both animal model studies and clinical studies. The role of HDAC1 in such a process was also elucidated ( Am J Transl Res . 2016; 8: 5256-5270. Oncotarget ; 2016; 7:54360-54369. Allergy, Asthma & Clin Immunol . 2016; 12:37. Sci Rep  2015; 5:17651) . 　 　

        (4) We found that mast cell-derived serine can convert antigen-specific Th2 cells to regulatory T cells (Sci Rep. 2014; 4: 4649) .   　 　

        (5) We found that the epithelial cell-derived integrin a vβ6 was a critical factor in the induction of immune tolerance under physiological conditions (Leuko J Biol 2011；90: 751-9).

D.  Research Support 　 　

Ongoing Research Support 　 　

Title: Investigation of the effects and mechanism by which the vaccine of allergen/VIP on food allergy. 　 　

Foundation: National Nature and Science Foundation 　 　

Type: Operation grant 　 　

Time: 2016-01 to 2018-12 　 　

Amount: 720,000 CNY 　 　

Role: Principle investigator

Title: A study of construction of immune regulatory vaccine 　 　

Foundation: Shenzhen Scientific Technological Committee 　 　

Type: Operation grant 　 　

Time: 2017-01 to 2018-12 　 　

Amount: 400,000 CNY 　 　

Role: Principle investigator

Title: Investigation into the mechanism of immune inflammation 　 　

Foundation: Shenzhen Scientific Technological Committee 　 　

Type: Operation grant 　 　

Time: 2017-01 to 2019-12 　 　

Amount: 5,000,000 CNY 　 　

Role: Principle investigator 　 　

Completed Research Support 　 　

Grant 19 　 　

Title: A study of the effects of Gal-1/allergen vaccine on restoring immune tolerance of the intestinal mucosa 　 　

Foundation: The innovation of science and Technology Commission of Shenzhen Municipality. 　 　

Time: 2013.01-2017.12. 　 　

Amount：300000 CNY 　 　

Role: Principle investigator

Grant 18 　 　

Title: Investigation of the effects and mechanism by which the B cell with TSP1 expression on food allergy. 　 　

Foundation: National Nature and Science Foundation 　 　

Type: Operation grant 　 　

Time: 2013.01-2017.12. 　 　

Amount: 700000 CNY 　 　

Role: Principle investigator

Grant 17 ( Sep  2012 -Aug 2017 ): $ 66 4 , 000 　 　

Foundation: CIHR (Canadian Institutes of Health Research; # 3 200 6 8) 　 　

Title: Role of A20 in regulation of intestinal immunity 　 　

My role: PI .

Grant 16 (May-August, 2012): $7000 (summer studentship) 　 　

Foundation: Canadian Association of Gastroenterology 　 　

Title: Role of A20 in maintaining intestinal epithelial barrier function 　 　

My role: Supervisor . Student name: Tahrin Mahmood.

Grant 15 (May-August, 2011): $7000 (summer studentship) 　 　

Foundation: Canadian Association of Gastroenterology 　 　

Title: Role of galectin 9 in maintaining intestinal epithelial barrier function 　 　

My role: Supervisor . Student name: Lee Cheng.

Grant 14 (Nov 2010~Oct 2013): $150,000.00 　 　

Foundation: CIHR (# 220058) 　 　

Title: Role of gut bacterial derived peptidoglycan in the induction of immune inflammation in the intestine 　 　

My role: PI .

Grant 13 (April 2009~March 2014): $125,000.00 　 　

Foundation: NSERC (# 371268) 　 　

Title: Impact on the biology of mucosal tolerance in exposure to haptenated antigens 　 　

My role: PI .

Grant 12 (Oct 2009~Sep 2014): $600,715.00. 　 　

Foundation: CIHR (# 191063) 　 　

Title: Role of dendritic cell in oral tolerance and food allergy 　 　

My role: PI.

Grant 11 (July 2008~June 2013): $300,000.00. 　 　

Foundation: CIHR (# 177843) 　 　

New Investigator Award 　 　

My role: PI.

Grant 10 (Sep 2007~Aug 2010, PI: Dr Peng-Yuan Zheng): 293,000.00 (RMB). 　 　

Foundation: Natural Science Foundation of China (NSFC) 　 　

Title: Role of microbial products in intestinal immune tolerance. 　 　

My role: Co-PI .

Grant 9. (Jul 2006~Jun 2009): $175806.00 　 　

Foundation: CIHR (#153168) 　 　

Title: Immune mechanisms of food allergy induced by concurrent exposure to microbial products and food antigens. 　 　

My role: PI .

Grant 8. From 2004-07-01 to 2006-06-30. (PI: Dr Changsheng Wang) 　 　

Foundation: The Scientific Foundation of Shanxi Province 　 　

Title: Determination a possible association between chronic sinusitis and ulcerative colitis. 　 　

Awarded: $50,000 (RMB). 　 　

My role: Co-PI

Grant 7. From Feb 2003 to Feb 2006 (PI: Dr Changqing Zhao) 　 　

Foundation: The Natural Science Foundation of China. 　 　

Title: The genetic mechanism of infectious chronic sinusitis 　 　

Awarded: $100,000 (RMB) 　 　

My role: Co-Investigator

Grant 6. From 2003-2005 (PI: Dr Johan S�derholm) 　 　

Title: Role of the follicle-associated epithelium in Crohn’s disease. 　 　

Foundation: Broad Medical Research Program. 　 　

Awarded: US$200,000. 　 　

My role : Collaborator 　 　

　 　

Grant 5. From 2003-2006 (PI: Dr Johan S�derholm) 　 　

Title: “Stress effects on the human intestinal mucosa” 　 　

Foundation:  Swedish Medical Research Council (2003-2005) and the Swedish Medical 　 　

Association (2004-06). 　 　

My role : Collaborator

Grant 4. #30388008. From 2004-07-01 to 2006-06-30. (PI: Dr Changqing Zhao) 　 　

Foundation: The Natural Scientific Foundation of China 　 　

Determination a possible association between chronic sinusitis and ulcerative colitis. 　 　

Major goal: To determine the role of sinusitis-derived Staphylococcus aureus B in pathogenesis of ulcerative colitis. 　 　

Role: Co-investigator

Grant 3. #9302092. From 1993-07-01 to 1995-06-30 　 　

Foundation: The Scientific Foundation of Educational Ministry of China 　 　

Title: Investigation of nasal immunity. 　 　

Major goal: To understand immune cell function in the nasal mucosa. 　 　

Role: PI .

Grant 2. #92030310. From 1992-07-01 to 1995-06-30 　 　

Foundation: The Natural Scientific Foundation of China 　 　

Title: Inhibition of IgE receptor expression on mouse intestinal epithelium with anti- e  fraction monoclonal antibodies. 　 　

Major goal: Via regulating IgE receptor expression to repress intestinal allergic reactions. 　 　

Role: PI .

Grant 1. #910017. From 1990-10-01 to 1993-09-30 (A new investigator award) 　 　

Foundation: The Scientific Foundation of Shanxi Province 　 　

Title: A study of IgE antibody in the patients with allergic diseases 　 　

Major goal: Evaluation of serum IgE levels in patients with allergic diseases in the course of treatment with specific antigen desensitization. 　 　

Role: PI .

E.  Peer-reviewed publications (*corresponding author) 　 　

1. Song JP#, Chen X#, Cheng L, Rao M, Chen K, Zhang N, Meng J, Li M, Liu ZQ, Yang PC. Vitamin D receptor restricts Th2-biased inflammation in the heart.   Cardovascular Res 2018 Feb; accepted. PMID: 29444238 　 　

2. An YF#, Geng XR#, Mo LH#, Liu JQ, Yang LT, Zhang XW, Liu ZG, Zhao CQ*, Yang PC*. The 3-methyl-4-nitrophenol (PNMC) compromises airway epithelial barrier function. Toxicology. 2018 Jan 4; 395:9-14. 　 　

3. Yang LT, Shu Q, Luo XQ, Liu ZQ, Qiu SQ, Liu JQ, Guo HJ, Li LJ, Li MG, Liu DB, Xia LX, Liu ZG*, Yang PC*. Long term effects of a combination of galectin-1 and specific immunotherapy on allergic response in the intestine. Allergy 2018 Jan;73 (1): 106-114. 　 　

4. Yang G#, Cheng BH#, Yang SB#, Liu ZQ, Qiu SQ, Yang LT, Xie RD, Geng XR, Li MG, Gao L, Liu ZG*, Yang PC*. Targeting histone-acetyltransferase Tip60 inhibits intestinal allergy. Allergy 2018 Feb; 73 (2): 387-394. 　 　

5. Lu H, Xie RD, Lin R, Zhang C, Xiao XJ, Li LJ, Liu ZQ, Yang LT, Feng BS, Liu ZJ*, Yang PC*. Vitamin D-deficiency induces eosinophil spontaneous activation. Cell Immunol 2017 Dec; 322: 56-63. 　 　

6. Jiao WH#, Cheng BH#, Shi GH, Chen GD, Gu BB, Zhou YJ, Hong LL, Yang F, Liu ZQ, Qiu SQ, Liu ZG, Yang PC*, Lin HW*. Dysivillosins A-D, Unusual Anti-allergic Meroterpenoids from the Marine Sponge Dysidea villosa. Sci Rep. 2017 Aug 21; 7 (1): 8947. 　 　

7. Hu T, Fan X, Ma L, Liu J, Chang Y, Yang PC, Qiu S, Chen T, Yang L*, Liu Z*. TIM4-TIM1 interaction modulates Th2 pattern inflammation through enhancing SIRT1 expression. Int J Mol Med 2017 Sep 25; 40: 1504-1510. 　 　

8. Yuan X, Wang E, Xiao X, Wang J, Yang X, Yang PC, Li G*, Liu Z*. The role of IL-25 in the reduction of oxidative stress and the apoptosis of airway epithelial cells with specific immunotherapy in an asthma mouse model. Am J Transl Res; 2017 Sep 15; 9 (9): 4137-4148. 　 　

9. Liao W, Zhou L, Zhao X, Song L, Lu Y, Zhong N, Yang PC, Sun B, Zhang X*. Thermoneutral housing temperature regulates T-regulatory cell function and inhibits ovabumin-induced asthma development in mice. Sci Rep 2017, Aug 2; 7 (1): 7123.   　 　

10. He J, Guo X, Liu ZQ, Yang PC, Yang S*. Vitamin D inhibits the Staphylococcal enterotoxin B-induced expression of tumor necrosis factor in microglial cells. Immunol Res. 2017 Aug; 65 (4): 913-919. 　 　

11. Lin RT, Liu JQ, Lu HY, Chen YM, Guan L, Liu ZG, Liu ZJ, Yang PC. Micro RNA-155 plays a critical role in the initiation of food allergen-related inflammation in the intestine. Oncotarget 2017 Jun 28; 8 (40): 67497-67505. 　 　

12. Wang H, Zeng L, Lin J, Ouyang C, Ran P*, Yang PC*, Liu ZG*. Der f 31, a novel allergen from Dermatophagoides farinae, activates epithelial cells and enhances lung-resident group 2 innate lymphoid cells. Sci Rep 2017; Aug 17; 7 (1): 8519. 　 　

13. Song L, Guo J, Liao W, Liu L, Chen T, Yang PC, Zhong N, Sun B, Zhang X. Long-term effects of adenotonsillectomy on serum specific immunoglobulin E: Results of a prospective study. Pediatric Res 2017 Nov; 82 (5): 801-805. 　 　

14. Liang ZL, Wang H, Hu W, Chen XX, Xia LX, Yang PC*, Liu ZG*, Liu XY*. Identification and characterization of three novel allergens from bombyx mori. Am J Transl Res 2017; Apr accepted. 　 　

15. Xue JM, Yang LT, Yang G, Geng XR, Liu ZQ, Wang S, Zhao HL, Liu ZG, Zhao CQ*, Yang PC*. Protease-activated receptor-2 suppresses interleukin (IL)-10 expression in B cells via up regulating Bcl2L12 in patients with allergic rhinitis. Allergy 2017 Nov; 72 (11): 1704-1712. 　 　

16. Liu FH, Li SS, Li XX, Wang S, Li MG, Guan L, Luan TG, Liu ZG, Liu ZJ*, Yang PC*. Vitamin D3 induces vitamin D receptor and HDAC11 binding to relieve the promoter of the tight junction proteins. Oncotarget 2017 May 8; 8 (35): 58781-58789. 　 　

17. Luo XQ, Shao JB, Xie RD, Zeng L, Li XX, Qiu SQ, Geng XR, Yang LT, Li LJ, Liu DB, Liu ZG*, Yang PC*. Micro RNA-19a interferes with IL-10 expression in peripheral dendritic cells of patients with nasal polyposis. Oncotarget 2017 Jul 25; 8 (30): 48915-48921. 　 　

18. Yu ZJ, Zeng L, Luo XQ, Geng XR, Xu R, Chen K, Yang G, Luo X, Liu ZQ, Liu ZG, Liu DB*, Yang PC*, Li HB*. Vitamin D3 inhibits micro RNA-17-92 to promote specific immunotherapy in allergic rhinitis. Sci Rep 2017; Apr 3; 7 (1): 546. 　 　

19. Song J*, Su W, Chen X, Zhao Q, Zhang N, Li MG, Yang PC, Wang L*. Micro RNA-98 suppresses interleukin-10 in peripheral B cells in patient post-cardio transplantation. Oncotarget 2017; Apr 25; 8 (17): 28237-28246. 　 　

20. Xie RD, Xu LZ, Yang LT, Wang S, Liu Q, Liu ZG*, Yang PC*. Galectin-1 inhibits oral-intestinal allergy syndrome. Oncotarget. 2017 Feb 21; 8 (8): 13214-13222. 　 　

21. Miao BP, Zhang RS, Sun HJ, Yu YP, Chen T, Li LJ, Liu JQ, Liu J, Yu HQ, Zhang M, Liu ZG*, Yang PC*. Inhibition of squamous cancer growth in a mouse model by Staphylococcal enterotoxin B-triggered Th9 cell expansion. Cell Mol Immunol 2017 Apr; 14 (4): 371-379. 　 　

22. Guo X, Li MG, Li SS, Liu FH, Liu ZJ*, Yang PC*. Tumor necrosis factor suppresses interleukin-10 in peripheral B cells via up regulating Bcl2-like protein 12 in patients with inflammatory bowel disease. Cell Biochem Funct 2017 Mar;35(2):77-82.   　 　

23. Liu ZQ, Li MG, Geng XR, Liu J, Yang G, Qiu SQ, Liu ZG*, Yang PC*. Vitamin D regulates immunoglobulin mucin domain molecule-4 expression in dendritic cells. Clin Exp Allergy 2017 May; 47 (5): 656-664.   　 　

24. Mo LH, Yang LT, Zeng L, Xu LZ, Zhang HP, Li LJ, Liu JQ, Liu XY, Zheng PY, Liu ZG*, Yang PC*. Dust mite allergen, glutathione S-transferase, induces T cell immunoglobulin mucin domain-4 in dendritic cells to facilitate initiation of airway allergy. Clin Exp Allergy 2017 Feb; 47(2): 264-270. 　 　

25. Liu XY, Xu LZ, Luo XQ, Geng XR, Liu ZQ, Yang LT, Yang G, Chen S, Liu ZG, Li HB, Yang LT, Luan TG*, Yang PC*. Forkhead box protein-3 (Foxp3)-producing dendritic cells suppress allergic response. Allergy. 2017 Jun; 72 (6): 908-917. 　 　

26. Liu ZQ, Li XX, Qiu SQ, Yu Y, Li MG, Yang LT, Li LJ, Wang S, Zheng PY, Liu ZG*, Yang PC*. Vitamin D contributes to mast cell stabilization. Allergy. 2017 Aug; 72 (8): 1184-1192. 　 　

27. Ma L, Xiao X, Ma Y, Wu H, Qiu S, Li J, Yang PC*, Liu Z*. Effect of activation of Toll-like receptor 7 in the inhibition of allergic asthma on a mouse model. Am J Transl Res. 2017 May 15; 9 (5): 2143-2152. 　 　

28. Liu J, Chen FH, Qiu SQ, Yang LT, Zhang HP, Liu JQ, Geng XR, Yang G, Liu ZQ, Li J, Liu ZG*, Li HB*, Yang PC*. Probiotics enhance the effect of allergy immunotherapy on regulating antigen specific B cell activity in asthma patients. Am J Transl Res. 2016 Dec 15; 8(12): 5256-5270. 　 　

29. Wang H, Hu W, Liang Z, Zeng L, Li J, Yan H, Yang PC*, Liu Z*, Wang L. Thiol peroxiredoxin, a novel allergen from Bombyx mori, modulates functions of macrophages and dendritic cells. Am J Transl Res. 2016; 8(12):5320-5329. 　 　

30. Xiao L, Yang B, Liu X, Luo Y, Ji Q, Wen Z, Liu Z*, Yang  PC*. Kinetic changes of intestinal microbiota in the course of intestinal sensitization. Oncotarget 2016;7(49):81197-81207. 　 　

31. Li LJ, Zeng L, Li XX, Mo LH, Geng XR, Zheng PY, Liu ZG, Feng BS*, Yang PC*. Induction of colitis in mice with food allergen-specific immune response. Sci Rep. 2016 Sep 8; 6: 32765. 　 　

32. Xu LZ, Yang LT, Qiu SQ, Yang G, Luo XQ, Miao BP, Geng XR, Liu ZQ, Liu J, Wen Z, Wang S, Zhang HP, Li J, Liu ZG, Li HB*, Yang PC*. Combination of specific allergen and probiotics induces specific regulatory B cells and enhances immunotherapy in allergic rhinitis. Oncotarget; 2016; 7(34):54360-54369. 　 　

33. Cai M, Zeng L, Li LJ, Mo LH, Xie RD, Feng BS, Zheng PY, Liu ZG, Liu ZJ*, Yang PC*. Specific immunotherapy ameliorates ulcerative colitis. Allergy, Asthma & Clin Immunol. 2016; 12:37. 　 　

34. Geng XR, Qiu SQ, Yang LT, Liu ZQ, Yang G, Liu JQ, Zeng L, Li XX, Mo LH, Liu ZG*, Yang PC*. Allergen-specific immune response suppresses interleukin-10 expression in B cells via increasing micro RNA-17-92 cluster. Cell Biochem Funct 2016; 34(6):449-54. 　 　

35. Yang B, Mo L, Zeng L, Li XX, Qiu S, Liu Z, Yang PC*. SEB/OVA facilitated TIM4 expression in intestinal antigen presenting cells via acetylation of histone H3. Int J Clin Med Allergy. 2016; 4:38-43.   　 　

36. Yang G, Zhang H, Liu Y, Feng Y, Luo XQ, Liu ZQ, Geng XR, Wang S, Zheng PY, Feng BS, Liu ZG, Yang PC, Li HB*, Wu SD*. Alternation of circadian clock modulates forkhead box protein-3 gene transcription in CD4+ T cells in the intestine. J Allergy Clin Immunol. 2016; 138(5):1446-1449. 　 　

37. Li LJ, Ma N, Zhang HP, Mo LH, Zeng L, Li XX, Xu LZ, Yang B, Liu ZG, Feng BS, Zheng PY, Yang PC*. Flagellin modulates IgE expression in B cells to initiate food allergy in mice. Am J Trasnl Res 2016; 8(6):2748-57. 　 　

38. Lin J, Wan Q, Gao A, Jiang C, Liu L, Liu Z, Yang PC*, Liu X*. Characterization of a novel allergen Der f 25, homologous to triose-phosphate isomerase, from Dermatophagoides farinae. Int J Clin Exp Med. 2016; 9(6):10829-10837. 　 　

39. Wang H, Lin J, Liu X, Lian Z, Yang PC*, Ran P*, Liu Z*. Identification of α-tubulin, Der f 33, as a novel allergen from Dermatophagoides farina. Immunobiology 2016; 221(8): 911-7. 　 　

40. Sun CY, Bai J, Hu TY, Cheng BH, Ma L, Fan XQ, Yang PC, Zheng PY, Liu ZQ. CD4+ T cell responses in Balb/c mice with food allergy induced by trinitrobenzene sulfonic acid and ovalbumin. Mol Med Rep 2016; 13(6):5349-57. 　 　

41. Liu ZQ, Yang G, Geng XR, Liu JQ, Mo LH, Liu ZG*, Yang PC*. Micro RNA-17-92 cluster mediates interleukin-4-suppressed IL-10 expression in B cells. Am J Trasnl Res 2016; 8 (5): 2317-24. 　 　

42. Yang B, Li LJ, Xu LZ, Liu JQ, Zhang HP, Geng XR, Liu ZG*, Yang PC*. Histone acetyltransferease p300 modulates TIM4 expression in dendritic cells. Sci Rep. 2016; 6: 21336. 　 　

43. Ge RT, Zeng L, Mo LH, Xu LZ, Zhang HP, Liu ZG*, Liu ZJ*, Yang PC*. Interaction of TIM4 and TIM3 induces T helper 1 cell apoptosis. Immunol Res 2016; 64(2): 470-5. 　 　

44. Lin J, Li M, Liang Z, Wu Y, Liu Z, Yang PC*, Liu X*. Characterization and analysis of a cDNA coding for the group 29b (Der f 29b) allergen of Dermatophagoides farina. Am J Transl Res 2016; 8(2): 568-77. 　 　

45. Yang L, Xu LZ, Liu ZQ, Yang G, Geng XR, Mo LH, Liu Z, Zheng PY, Yang PC. Interleukin-13 represses p53 expression to interfere with the activation-induced T cell apoptosis. Cell Mol Immunol. 2016;13(5):669-77. 　 　

46. Xing P, Xiao X, Liu Y, Jiang C, Mo L, Zhang M, Yang PC*, Liu Z*. Characterization of arginine kinase, a novel allergen of dermatophagoides farinae (Der f 20). Am J Transl Res 2015;7(12): 2815-23. 　 　

47. Luo X, Han M, Liu J, Wang Y, Luo X, Zheng J, Wang S, Liu Z, Liu D, Yang PC*, Li H*. Epithelial cell-derived micro RNA-146a generates interleukin-10-producing monocytes to inhibit nasal allergy. Sci Rep. 2015; 5: 15937. 　 　

48. Lin JL, Wan YY, Xiao XJ, Wu YL, Sun BQ, Gao AJ, Liu ZG, Li J, Yang PC*, Liu XY*. Characterization of a new subtype of allergen in dermatophagoides farinae—Der f 28. J Thorac Dis 2015; 7 (10): 1832-1839. 　 　

49. Mei L, Tang Y, Li M, Yang PC, Liu Z, Yuan J, Zheng P*. Co-Administration of Cholesterol-Lowering Probiotics and Anthraquinone from Cassia obtusifolia L. Ameliorate Non-Alcoholic Fatty Liver. PLoS One 2015; 10: e0138078. 　 　

50. Shi Y, Xu LZ, Peng K, Wu W, Wu R, Liu ZQ, Yang G, Geng XR, Liu J, Liu ZG*, Liu Z*, Yang PC*. Specific immunotherapy in combination with Clostridium butyricum inhibits allergic inflammation in the mouse intestine. Sci Rep 2015; 5:17651. 　 　

51. Lin J, Li M, Liu Y, Jiang C, Wu Y, Wang Y, Gao A, Liu Z, Yang PC*, Liu X*. Expression, purification and characterization of Der f 27, a new allergen from dermatophagoides farina. Am J Transl Res 2015; 7: 1260-70. 　 　

52. Jiang C, Fan X, Li M, Xing P, Liu X, Wu Y, Zhang M, Yang PC*, Liu Z*. Characterization of Der f 29, a new allergen from dermatophagoides farina. Am J Transl Res 2015; 7: 1303-13. 　 　

53. Liu JQ, Li XY, Yu HQ, Mo LH, Zeng L, Zhao M, Fu YT, Sun HZ, Liu ZG, Yang PC*. A tumor-specific Th2 response inhibits the growth of CT26 colon-cancer cells in mice via converting intratumor regulatory T cells to Th9 cells. Sci Rep 2015; 5: 10665. 　 　

54. Fang LL, Yu HQ, Wu RJ, He C, Li M, Yan H, Li JJ, Wang S, Liu ZG, Liu ZJ, Yang PC*. Thrombospondin 1 modulates monocyte properties to suppress intestinal mucosal inflammation. J Innate Immunity 2015; 7: 601-11.   　 　

55. Yang G, Geng XR, Liu ZQ, Liu JQ, Liu XY, Xu LZ, Zhang HP, Sun YX, Liu ZG, Yang PC*. TSP1-producing B cells restore Ag specific immune tolerance in an allergic environment. J Biol Chem 2015; 290: 12858-67.   　 　

56. Jiang J, Liu JQ, Li J, Li M, Chen HB, Yan H, Mo LH, Qiu SQ, Liu ZG, Yang PC*. Trek1 contributes to maintaining nasal epithelial barrier integrity. Sci Rep. 2015;5:9191. 　 　

57. Huang H, Liu JQ, Yu Y, Mo LH, Ge RT, Zhang HP, Liu ZG, Zhang PY, Yang PC*. To regulate TWIK-related potassium channel-1 (Trek1) restitutes the intestinal epithelial barrier function. Cell Mol Immunol 2016;13(1):110-8. 　 　

58. Ge RT, Mo LH, Wu R, Liu JQ, Zhang HP, Liu Z, Liu Z, Yang PC*. Insulin-like growth factor-1 endues monocytes with immune suppressive ability to inhibit inflammation in the intestine. Sci Rep 2015; 5: 7735. 　 　

59. Miao BP, Zhang RS, Li M, Fu YT, Zhao M, Liu ZG, Yang PC*. Nasopharyngeal cancer-derived micro RNA-21 promotes immune suppressive B cells. Cell Mol Immunol 2015; Nov;12(6):750-6.   　 　

60. Li L, Mo L, Hao H, Yang W, Zhou Q, Xue F, Shi Z, Liu Z, Yang PC*, Feng B. Flagellin modulates TIM4 expression in mast cells. Cell Biol Int. 2014;38(11):1330-6. 　 　

61. Geng XR, Yang G, Li M, Song JP, Liu ZQ, Qiu S, Liu Z, Yang PC*. Insulin-like growth factor-2 enhances functions of Ag specific regulatory B cells. J Biol Chem. 2014; 289:17941-50. 　 　

62. He W, Yang C, Xia L, Zhao MZ, Ge RT, Huang H, Ji Q, Yang PC*, Liu Z*. CD4+ T cells from food allergy model are resistant to TCR-dependent apoptotic induction. Cytokine. 2014. 68: 32-9. 　 　

63. Yan H, Yi H, Xia L, Zhan Z, He W, Cao J, Yang PC*, Liu Z. Staphylococcal enterotoxin B suppresses Alix and compromises intestinal epithelial barrier functions. J Biomed Sci. 2014. 21(1): 29. 　 　

64. Liu ZQ, Song JP, Liu X, Jiang J, Chen X, Yang L, Hu T, Zheng PY, Liu ZG, Yang PC*. Mast cell-derived serine proteinase regulates T helper 2 polarization.  Sci Rep. 2014. 4: 4649. 　 　

65. Yang G, Geng XR, Song JP, Wu YY, Yan H, Zhan Z, Yang L, He W, Liu ZQ, Qiu S, Liu Z, Yang PC*. Insulin-like growth factor-2 enhances regulatory T cell functions and suppresses food allergy in an experimental model. J Allergy Clin Immunol 2014; 133(6): 1702-1708. 　 　

66. Yu Y, Chen S, Lu GF, Wu Y, Mo L, Liu ZQ, Zheng PY, Liu Z, Yang PC*. Alphavbeta6 is required in maintaining intestinal epithelial barrier function. Cell Biol Int. 2014. 38: 777-81. 　 　

67. Wu W, Sun M, Zhang HP, Chen T, Wu R, Liu C, Yang G, Geng XR, Feng BS, Liu ZG, Liu Z, Yang PC. Prolactin mediates psychological stress-induced dysfunction of regulatory T cells to facilitate intestinal inflammation. Gut. 2014. 63 (12): 1883-92. 　 　

68. Zhang HP, Wu YY, Liu J, Jiang J, Geng XR, Yang G, Mo L, Liu ZQ, Liu ZG, Yang PC.  TSP1-producing B cells show immune regulatory property and suppress allergy-related mucosal inflammation. Sci Rep. 2014; 3: 3345. 　 　

69. Wei Y, Xia W, Ye X, Fan Y, Shi J, Wen W, Yang P, Li H; of the Nasal Health Group, China (NHGC). The antimicrobial protein short palate, lung, and nasal epithelium clone 1 (SPLUNC1) is differentially modulated in eosinophilic and noneosinophilic chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol. 2014; 133: 420-8. 　 　

70. He C, Song CH, Cheng L, Chen T, Liu C, Liu Z, Yang PC. Measles virus-derived peptide/food antigen adducts facilitate the establishment of antigen specific oral tolerance. J Physiol Pharmacol. 2013; 64(1): 95-102. 　 　

71. Yu Y, Liu ZQ, Liu XY, Yang L, Geng XR, Yang G, Liu ZG, Zheng PY, Yang PC. Stress-Derived Corticotropin Releasing Factor Breaches Epithelial Endotoxin Tolerance. PLoS One. 2013; 8(6):e65760. 　 　

72. He SH*, Zhang HY, Zeng XN, Chen D, Yang PC. Mast cells and basophils are essential for allergies: mechanisms of allergic inflammation and a proposed procedure for diagnosis. Acta Pharmacol Sin. 2013; 34:1270-83. 　 　

73. Liu X, Yang G, Geng XR, Cao Y, Li N, Ma L, Chen S, Yang PC*, Liu Z*. Microbial products induce Claudin-2 to compromise gut epithelial barrier function. Plos One 2013; 8:e68547. 　 　

74. Liu ZQ, Wu Y, Song JP, Liu X, Liu Z, Zheng PY, Yang PC*. Tolerogenic CX3CR1+ B cells suppress food allergy-induced intestinal inflammation in mice. Allergy 2013; 68: 1241-8. 　 　

75. Liu X, Feng BS, Kong X, Xu H, Li X, Yang PC, Liu Z. Food-Cooking Processes Modulate Allergenic Properties of Hen's Egg White Proteins. Int Arch Allergy Immunol. 2013;160:134-42. 　 　

76. Xiao X, Fu A, Xie X, Kang M, Hu D, Yang PC, Liu Z. An Investigation of Airborne Allergenic Pollen at Different Heights. Int Arch Allergy Immunol 2013;160:143-151. 　 　

77. Yang SB, Li TL, Chen X, An YF, Zhao CQ, Wen JB, Tian DF, Wen Z, Xie MQ, Yang PC. Staphylococcal enterotoxin B-derived haptens promote sensitization. Cell Mol Immunol. 2013;10:78-83. 　 　

78. Liu ZQ, Yang PC. Construction of pET-32α (+) vector for protein expression and purification. N A J Med Sci 2012; 4: 651-655. 　 　

79. Wu D, Liu X, Su H, Chen X, Zhang H, Hu D, Huang Z, Yang PC, Liu Z. Oral antigens induce rheumatoid arthritis-like inflammation in a rat model. Inflam Res 2012; 　 　

80. Xue FM, Zhang HP, Hao HJ, Shi ZY, Zhou C, Feng BS, Yang PC. CD98 positive eosinophils contribute to T helper 1 pattern inflammation. Plos One 2012; 7(12): e51830. 　 　

81. Mahmood T, Yang PC. OX40L-OX40 interactions: A possible target for gastrointestinal autoimmune diseases. North Am J Med Sci 2012;4:533-6 　 　

82. Li TL, Zhang SY, Du YC, Yang PC. Deficiency of ubiquitin A20 promotes antigen transport across airway epithelial cells via a transcellular pathway. Anal Biochem. 2013 Feb 15; 433 (2): 86-91. 　 　

83. Mahmood T, Yang PC. Western blot: technique, theory, and trouble shooting. N Am J Med Sci. 2012;4:429-34. 　 　

84. Chen C, Yang G, Geng X-R, Wang X, Liu Z, Yang PC. TNFAIP3 Facilitates Degradation of Microbial Antigen SEB in Enterocytes. PLoS One 2012; 7(9): e45941. 　 　

85. An YF, Li TL, Geng XR, Yang G, Zhao CQ, Yang PC. Ubiquitin A20 facilitates processing microbial product in nasal epithelial cells. J Biol Chem. 2012; 287: 35318-23. 　 　

86. Liu ZQ, Zheng PY, Yang PC. Hapten Facilitates Food Allergen-Related Intestinal Hypersensitivity. Am J Med Sci. 2013 May;345(5):375-9. 　 　

87. Song CH, Liu ZQ, Huang S, Zheng PY, Yang PC. Probiotics promote endocytic allergen degradation in gut epithelial cells. Biochem Biophys Res Commun. 2012; 426: 135–140. 　 　

88. Huang P, Geng XR, Yang G, Chen C, Liu Z, Yang PC. Ubiquitin E3 Ligase A20 Contributes to Maintaining Epithelial Barrier Function. Cell Physiol Biochem. 2012;30:702-710. 　 　

89. Liu T, Ma J, Li TL, Yang JF, Liang X, Yang PC. High expression of CD98 alters epithelial barrier functions to promote induction of airway allergy. Clinical & Experimental Allergy, 2012; 42, 1051-1059. 　 　

90. He SH, Song CH, Liu Z, Zhang H, Ma W, Zhou LF, Mahmood T, Yang PC. Eosinophil-derived interferon-lambda contributes to initiation of allergen-related inflammation in the intestine. Cytokine. 2012;58:186-92. 　 　

91. Liu Z, Feng BS, Yang SB, Chen X, Su J, Yang PC. Interleukin (IL)-23 suppresses IL-10 in inflammatory bowel disease. J Biol Chem. 2012;287:3591-7. 　 　

92. Yang SB, Du Y, Wu BY, Xu SP, Wen JB, Zhu M, Cai CH, Yang PC, Integrin alphavbeta6 promotes tumor tolerance in colorectal cancer. Cancer Immunol Immunother 2012;61:335-42. 　 　

93. Liu T, Liang X, Li TL, Ma J, Yang JF, Yang PC. Staphylococcal enterotoxin B compromises the immune tolerant status in the airway mucosa. Clin Exp Allergy 2012; 42(3):375-82. 　 　

94. Xie MQ, Liu J, Long Z, Tian DF, Zhao CQ, Yang PC. Modulation of immune tolerance with a Chinese traditional prescription inhibits allergic rhinitis in mice. N Am J Med Sci. 2011 Nov;3(11):503-7. 　 　

95. Duncker SC, Kamiya T, Wang L, Yang PC, Bienenstock J. Probiotic Lactobacillus reuteri Alleviates the Response to Gastric Distension in Rats. J Nutr. 2011;141:1813-8. 　 　

96. He S, Zhang Z, Zhang H, Wei J, Yang L, Yang H, Sun W, Zeng X, Yang PC. Analysis of Properties and Proinflammatory Functions of Cockroach Allergens Per a 1.01s. Scand J Immunol. 2011;74(3):288-295. 　 　

97. Wang BQ, Zhang CM, Gao W, Wang XF, Zhang HL, Yang PC. Cancer-derived matrix metalloproteinase-9 contributes to tumor tolerance, J Cancer Res Clin Oncol 2011; 137:1525-33. 　 　

98. Qiu S, Du Y, Duan X, Geng X, Xie J, Gao H, Yang PC. Cytotoxic T lymphocytes mediate chronic inflammation of the nasal mucosa of patients with atypical allergic rhinitis. North Am J Med Sci 2011; 3: 378-383. 　 　

99. Chen X, Song CH, Feng BS, Li TL, Li P, Zheng PY, Chen XM, Xing Z, Yang PC. Intestinal epithelial cell-derived integrin {alpha}{beta}6 plays an important role in the induction of regulatory T cells and inhibits an antigen-specific Th2 response. J Leukoc Biol. 2011;90:751-9. 　 　

100. Nurtanio N, Yang PC. Role of TIM-4 in innate or adaptive immune response. North Am J Med Sci 2011; 3: 217-221.     　 　

101. He SH, Chen X, Song CH, Liu ZQ, Zhou LF, Ma WJ, Zhao LD, Li TL, Tang SG, Xing Z, Yang PC . A novel interferon lambda-mediated pathway in establishment of oral tolerance and inhibition of antigen-specific Th2 polarized gut inflammation. Gastroenterology 2011; 141:249-258. 　 　

102. He SH, Liu ZQ, Chen X, Song CH, Zhou LF, Ma WJ, Cheng L, Du Y, Tang SG, Yang PC . IL-9+ IL-10+ T cells link immediate allergic response to late phase reaction. Clin Exp Immunol 2011; 165(1):29-37. 　 　

103. Shaler CR, Kugathasan K, McCormick S, Damjanovic D, Horvath C, Small CL, Jeyanathan M, Chen X, Yang PC, Xing Z. Pulmonary Mycobacterial Granuloma Increased IL-10 Production Contributes to Establishing a Symbiotic Host-Microbe Microenvironment. Am J Pathol. 2011 178:1622-34. 　 　

104. Chen X, Song CH, Zhi-Qiang Liu ZQ, Feng BS, Zheng PY, Li P, In SH, Tang SG, Yang PC . Intestinal epithelial cells express galectin-9 in patients with food allergy that plays a critical role in sustaining allergic status in mouse intestine. Allergy 2011; 66:1038-46. 　 　

105. Liu ZQ, Yang PC . Hapten may play an important role in food allergen-related intestinal immune inflammation. North Am J Med Sci 2011; 3: 103-106.     　 　

106. Liu Z, Chen X, Wang X, Chen X, Song C, Du Y, Su J, Yaseen S, Yang PC . Chemokine CXCL11 links microbial stimuli to intestinal inflammation. Clin Exp Immunol 2011; 164:396-406. 　 　

107. Liu Z, Yadav PK, Xu X, Su J, Chen C, Tang M, Lin H, Yu J, Qian J, Yang PC, Wang X. The increased expression of IL-23 in inflammatory bowel disease promotes intraepithelial and lamina propria lymphocyte inflammatory responses and cytotoxicity. J Leuk Biol 2011; 89:597-606. 　 　

108. Liu T, Song CH, Liu AM, Xie C, Zhao F, Chen X, Cheng L, Yang PC . Foxp3(+) T cells express IL-17 in nasal mucosa of patients with both allergic rhinitis and polyposis. Clin Exp Immunol 2011;163:59-64. 　 　

109. Yang S, Wang B, Guan C, Wu B, Cai C, Wang M, Zhang B, Liu T, Yang PC . Foxp3+IL-17+ T cells promote development of cancer-initiating cells in colorectal cancer. J Leukoc Biol. 2011;89: 85-91. 　 　

110. Liu T, Li TL, Zhao F, Xie C, Liu AM, Chen X, Song CH, Cheng L, Yang PC . Role of thymic stromal lymphopoietin in the pathogenesis of nasal polyposis. Am J Med Sci 2011;  341: 40-7. 　 　

111. He S, Li T, Chen H, Ma W, Yao Q, Yang H, Wang H, Wang F, Zhao C, Yang PC . CD14+ cell-derived IL-29 modulates proinflammatory cytokine production by CD4+ T cells under allergic environment. Allergy 2011; 66: 238-246. 　 　

112. Song H, Yang PC . Construction of shRNA lentiviral vector. North Am J Med Sci 2010; 2: 598-601.    　 　

113. Vicario M, Guilarte M, Alonso C, Yang PC, Mart''nez C, Ramos L, Lobo B, Gonz''lez A, Guil'' M, Pigrau M, Saperas E, Azpiroz F, Santos J. Chronological assessment of mast cell-mediated gut dysfunction and mucosal inflammation in a rat model of chronic psychosocial stress. Brain Behav Immun. 2010; 24:1166-75.. 　 　

114. Yuan H, Xu S, Wang Y, Xu H, Wang C, Zhu Q, Yang RK, Chen X, Yang PC, Shi X. Corticotrophin-releasing hormone (CRH) facilitates axon outgrowth. Spinal Cord. 2010; 48: 850-6. 　 　

115. He S, Zhang H, Chen H, Yang H, Huang T, Chen Y, Lin J, Wang F, Chen X, Li T-L, Yang PC . Expression and release of IL-29 by mast cells and modulation of mast cell behavior by IL-29. Allergy 2010; 65: 1234–1241. 　 　

116. Zhang LL, Chen X, Zheng PY, Luo Y, Lu GF, Liu ZQ, Huang H, Yang PC. Oral Bifidobacterium modulates intestinal immune inflammation in mice with food allergy. J Gastroenterol Hepatol. 2010;25:928-34. 　 　

117. van der Kleij H, Charles N, Karimi K, Mao YK, Foster J, Janssen L, Yang PC, Kunze W, Rivera J, Bienenstock J. Evidence for neuronal expression of functional Fc (epsilon and gamma) receptors. J Allergy Clin Immunol. 2010;125:757-60. 　 　

118. Zhao CQ , Li TL, He SH, Chen X, An YF, Wu WK, Zhou XH, Li P, Yang PC . Specific immunotherapy suppresses Th2 responses via modulating TIM1/TIM4 interaction on dendritic cells. Allergy 2010; 65:986-995. 　 　

119. Liu T, Xie C, Chen X, Zhao F, Liu AM, Cho DB, Chong J, Yang PC . Role of muscarinic receptor activation in regulating immune cell activity in nasal mucosa. Allergy 2010; 65:969-977. 　 　

120. Zhang Z, Liu ZQ, Zheng PY, Tang FA, Yang PC. Influence of efflux pump inhibitors on the multidrug resistance of Helicobacter pylori. World J Gastroenterol. 2010;16:1279-84. 　 　

121. Yang SB , Chen X, Wu BY, Wang MW, Cai CH, Cho DB, Chong J, Li P, Tang SG, Yang PC . Expression of both Ig kappa and Ig lambda is required by stabilizing Bcl-xL expression in colorectal cancer. Scand J Gastroenterol 2009 44:1443-51. 　 　

122. Feng BS, Chen X, Li P, Zheng PY, Chong J, Chao DB, He SH, Tang SG, Yang PC . Expression of integrin alphavbeta6 in the intestinal epithelial cells of patients with inflammatory bowel disease. North Am J Med Sci 2009; 1: 200-204. 　 　

123. Zheng PY, Feng BS, Oluwole C, Struiksma S, Chen X, Li P, Tang SG, Johan D. S''derholm JD, Yang PC . Psychological stress induces eosinophils to produce corticotrophin releasing hormone in the intestine. Gut. 2009; 58:1473-9. 　 　

124. Yang PC , Tu YH, Perdue MH, Oluwole C, Struiksma S. Regulatory effect of heat shock protein 70 in stress-induced rat intestinal epithelial barrier dysfunction. North Am J Med Sci 2009; 1: 1-7. 　 　

125. Tu YH, Oluwole C, Struiksma S, Perdue MH, Yang PC . Mast cells modulate transport of CD23/IgE/antigen complex across human intestinal epithelial barrier. North Am J Med Sci 2009; 1: 8-17. 　 　

126. Liu T, Chen X, Feng BS, He SH, Zhang TY, Wang BQ, Yang PC . Glucuronoxylomannan promotes the generation of antigen-specific T regulatory cell that suppresses the antigen specific Th2 response upon activation. J Cell Mol Med 2009; 13: 1765-1774. 　 　

127. Chen X, Zheng PY, Feng BS, Chong J, Tang SG, Yang PC . A novel mechanism by which microbial products induce and perpetuate immune inflammation in the intestine. Am J Pathol 2008;173:1647-1656. 　 　

128. Liu ZQ, Zheng PY, Yang PC. Efflux pump gene hefA of Helicobacter pylori plays an important role in multidrug resistance. World J Gastroenterol. 2008;14:5217-22. 　 　

129. Teitelbaum AA, Gareau MG, Jury J, Yang PC, Perdue MH. Chronic peripheral administration of corticotropin-releasing factor causes colonic barrier dysfunction similar to psychological stress. Am J Physiol Gastrointest Liver Physiol. 2008;295:G452-9. 　 　

130. Feng BS, Zheng PY, Chen X, Liao XQ, Yang PC . Investigation of the role of cholera toxin in assisting the initiation of the antigen-specific Th2 response. Immunol Invest 2008; 37:782-97.. 　 　

131. Feng BS, Chen X, He SH, Zheng PY, Foster JA, Xing Z, Bienenstock J, Yang PC . Disruption of TIM1/TIM4 interaction as a therapeutic strategy in a DC-induced peanut allergy model. J Allergy Clin Immunol 2008; 122:55-61. 　 　

132. Keita A, Salim S, Jiang T, Yang PC, Franz''n L, S''derkvist P, Magnusson KE, S''derholm J. Increased uptake of non-pathogenic E. coli via the follicle-associated epithelium in longstanding ileal Crohn's disease. J Pathol. 2008; 215:135-44. 　 　

133. Wallon C, Yang PC, Keita AV, Ericson AC, McKay DM, Sherman PM, Perdue MH, S''derholm JD. Corticotropin-releasing hormone (CRH) regulates macromolecular permeability via mast cells in normal human colonic biopsies in vitro. Gut. 2008;57:50-8. 　 　

134. Lu GF, Tang FA, Zheng PY, Yang PC, Qi YM. Entecavir up-regulates dendritic cell function in patients with chronic hepatitis B. World J Gastroenterol 2008; 14: 1617-21. 　 　

135. Yang PC , He SH, Zheng PY. Investigation into the signal transduction pathway via which heat stress impairs intestinal epithelial barrier function. J Gastroenterol Hepatol. 2007;22:1823-31. 　 　

136. Luketic L, Delanghe J, Sobol PT, Yang PC, Frotten E, Mossman KL, Gauldie J, Bramson J, Wan Y. Antigen presentation by exosomes released from peptide-pulsed dendritic cells is not suppressed by the presence of active CTL. J Immunol. 2007;179:5024-32. 　 　

137. Kugathasan K, Roediger EK, Small CL, McCormick S, Yang PC, Xing Z. CD11c+ antigen presenting cells from the alveolar space, lung parenchyma and spleen differ in their phenotype and capabilities to activate na''ve and antigen-primed T cells. BMC Immunol. 2008;9:48. 　 　

138.  Yang PC, Xing Z, Berin MC, Solderholm JD, Feng BS, Wu L, Yeh C. TIM-4 expressed by mucosal dendritic cells plays a critical role in food antigen specific Th2 differentiation and intestinal allergy. Gastroenterology. 2007; 133:1522-33 (with an editorial commentary paper in the same issue, page 1723-6). 　 　

139. Feng BS, He SH, Zheng PY, Wu L, Yang PC . Mast cells play a crucial role in Staphylococcus aureus peptidoglycan-induced diarrhea. Am J Pathol 2007; 171: 537-547 (with a commentary paper on page 399-401 of the same issue). 　 　

140. Wu L, Feng BS,  He SH,  Zheng PY,  Croitoru K, Yang PC . Bacterial peptidoglycan breaks down intestinal tolerance via mast cell activation; the role of TLR2 and NOD2. Immuno Cell Biol. 2007; 85: 538-45. 　 　

141. Liu T, He SH, Zheng PY, Zhang TY, Wang BQ, Yang PC . Staphylococcal enterotoxin B increases TIM4 expression in human dendritic cells that drives naive CD4 T cells to differentiate into Th2 cells. Mol Immunol. 2007; 44: 3580-3587. 　 　

142. Yang PC , He SH, Zheng PY. Investigation into the signal transduction pathway via which heat stress impairs intestinal epithelial barrier function. J Gastroenterol Hepatol. 2007;22:1823-31. 　 　

143. Zheng PY, Zhang DY, Lu GF, Yang PC, Qi YM, Wang BS. Effects of lamivudine on the function of dendritic cells derived from patients with chronic hepatitis B virus infection. World J Gastroenterol 2007; 13(34): 4641-4645. 　 　

144. Boudry G, Jury J, Yang PC, Perdue MH. Chronic psychological stress alters epithelial cell turn-over in rat ileum. Am J Physiol Gastrointest Liver Physiol. 2007; 292:G1228-32. 　 　

145. Gareau MG, Jury J, Yang PC, MacQueen G, Perdue MH. Neonatal maternal separation causes colonic dysfunction in rat pups including impaired host resistance. Pediatr Res. 2006;59(1):83-8. 　 　

146. Liu T, Wang BQ, Zheng PY, He SH, Yang PC . Rhinosinusitis derived Staphylococcal enterotoxin B plays a possible role in the pathogenesis of food allergy. BMC Gastroenterology 2006, 6:24 　 　

147. Liu T, Wang BQ, Wang CS, Yang PC . Concurrent exposure to thermal stress and oral Ag induces intestinal sensitization in the mouse by a mechanism of regulation of IL-12 expression. Immunol Cell Biol 2006; 84: 430-439. 　 　

148. Liu T, Wang BQ, Yang PC . A possible link between sinusitis and lower airway hypersensitivity, the role of Staphylococcal enterotoxin B. Clinical and Molecular Allergy 2006, May 7;4(1):7. 　 　

149. Yang PC , Wang CS. Heat stress increases protein antigen transport across the intestinal epithelium via a mechanism of impairing proteolytic enzymatic activity. Dig Dis Sci. 2006 May;51(5):1003-11. 　 　

150. Yang PC , Liu T, Kong WJ, Wang BQ: A Possible Association Of Staphylococcus Enterotoxin B As A Cause Of Asthma In The Presence Of Sinusitis. Int J Otorhinolaryngol. 2006. 4 (2):1-7. 　 　

151. Yang PC , Jury J, Soderholm JD, Sherman PM, McKay DM, Perdue MH. Chronic psychological stress in rats induces intestinal sensitization to luminal antigens, Am J Pathol 2006;168 104-114 (with a commentary paper on page 3-5 of the same issue). 　 　

152. Porras M, Martin MT, Yang PC, Jury J, Perdue MH, Vergara P.Correlation Between Cyclical Epithelial Barrier Dysfunction and Bacterial Translocation in the Relapses of Intestinal Inflammation. Inflamm Bowel Dis. 2006 Sep;12(9):843-852. 　 　

153. Zareie M, Johnson-Henry KC, Jury J, Yang PC, Ngan BY, McKay DM, Soderholm JD, Perdue MH, Sherman PM. Probiotics prevent bacterial translocation and improve intestinal barrier function in rats following chronic psychological stress. Gut. 2006; 55:1553-60. 　 　

154. Yang PC , Zheng PY, Wang CS, Tian DF. Lipopolysaccharide activates human mast cells to induce intestinal epithelial barrier dysfunction. Int J Gastroenterol 2005; Volume 4 Number 1. 　 　

155. Yang PC , Liu T, Wang BQ, Zhang TY, Zheng PY. Rhinosinusitis derived Staphylococcal enterotoxin B acts as a Trojan horse in the pathogenesis of ulcerative colitis. BMC Gastroenterology 2005; 5 (28): 1-11. 　 　

156. Yang PC , Wang CS, An ZY. A Murine Model of Ulcerative Colitis: Induced with Sinusitis-Derived Superantigen and Food Allergen. BMC Gastroenterol. 2005 Mar 3;5 (6): 1-10. 　 　

157. Jacob C, Yang PC (equal to the first author, Darmoul D, Amadesi S, Cottrell GS, Saito T, Singh P, Grady EF, Perdue MH, Bunnett NW. Mast cell tryptase controls paracellular permeability of the intestine: role of protease-activated receptor 2 and b-arrestines. J Biol Chem 2005; 280: 31936-31948. 　 　

158. J D So''derholm, C Streutker, P-C Yang, C Paterson, P K Singh, D M McKay, P M Sherman, K Croitoru, M H Perdue. Increased epithelial uptake of protein antigens in the ileum of Crohn’s disease mediated by tumour necrosis factor α. Gut 2004; 53: 1817–1824. 　 　

159. Nazli A, Yang PC, Jury J, et al. Epithelia under metabolic stress perceive commensal bacteria as a threat. Am J Pathol 2004; 164: 947-957. 　 　

160. Cameron HL, Yang PC, Perdue MH. Glucagon-like peptide-2-enhanced barrier function reduces pathophysiology in a model of food allergy. Am J Physiol Gastrointest Liver Physiol. 2003 Jun; 284(6): G905-12. 　 　

161. Yu LC, Montagnac G, Yang PC, Conrad DH, Benmerah A, Perdue MH. Intestinal epithelial CD23 mediates enhanced antigen transport in allergy: evidence for novel splice forms. Am J Physiol Gastrointest Liver Physiol. 2003; 285: G223-34. 　 　

162. Cameron HL, Yang PC, Perdue MH.  Glucagon-like peptide-2-enhanced barrier function reduces pathophysiology in a model of food allergy. Am J Physiol Gastrointest Liver Physiol. 2003 Jun; 284(6): G905-G912. 　 　

163. Yu LC, Montagnac G, Yang PC, Conrad DH, Benmerah A, Perdue MH.  Intestinal Epithelial CD23 Mediates Enhanced Antigen Transport in Allergy: Evidence for Novel Splice Forms. Am J Physiol Gastrointest Liver Physiol. 2003 Jul;285(1):G223-34. 　 　

164. Soderholm JD, Yates DA, Gareau MG, Yang PC, MacQueen G, Perdue MH.  Neonatal maternal separation predisposes adult rats to colonic barrier dysfunction in response to mild stress. Am J Physiol Gastrointest Liver Physiol. 2002 Dec;283(6):G1257-63. 　 　

165. Di Leo V, Yang, PC, Berin MC, Perdue MH. Factors Regulating the Effect of IL-4 on Intestinal Epithelial Barrier Function. Int Arch Allergy Immunol. 2002 Nov;129(3):219-27. 　 　

166. Soderholm JD, Yang PC, Ceponis P, et al. Chronic stress induces mast cell-dependent bacterial adherence and initiates mucosal inflammation in Rat intestine. Gastroenterology. 2002; 123: 1099-1108. 　 　

167. Yang PC , Zeng HY, Zhang TY, Zheng YQ, Chen JZ. The effects of sensitization and hypersensitivity reaction on transepithelial antigen transport of rabbit nasal mucosa. Otolaryngol Head Neck Surg. 2001; 125: 54-9. 　 　

168. Yang PC , Berin MC, Yu L and Perdue MH. Mucosal Pathophysiology and Inflammatory Changes in the Late Phase of the Intestinal Allergic Reaction in the Rat. American Journal of Pathology. 2001;158:681-690. 　 　

169. Yu LCH, Yang PC, Berin MC, Di Leo V, Conrad DH, McKay DM, Satoskar AR, Perdue MH. Enhanced transepithleial antigen transport in intestine of allergic mice is mediated by IgE/CD23 and regulated by interleukin-4. Gastroenterology 2001; 121: 370-381. 　 　

170. Tang C, Inman MD, Rooijen Nv, Yang PC, Shen H, Matsumoto K, O’Burne PM. Th type 1-stimulating activity of lung macrophages inhibits Th2-mediated allergic airway inflammation by an IFN-g-dependent mechanism. J Immunol 2001; 166: 1471. 　 　

171. Santos J, Yang PC, Soderholm JD, Benjamin M, Perdue MH. Role of mast cells in chronic stress induced colonic epithelial barrier dysfunction in the rat. Gut; 2001; 48:630-636. 　 　

172. Yang PC , Berin MC, Yu LC, Conrad DH, Perdue MH. Enhanced intestinal transepithelial antigen transport in allergic rats is mediated by IgE and CD23. J Clin Invest. 2000 Oct;106(7):879-86. 　 　

173. Liu T, Yang PC, Wang CS, Zhang NZ. Effect of superantigen on ion electrophysiology and permeability in rabbit maxillary sinus epithelium. Chinese Med J (Peking) 2000; 113: 938-941. 　 　

174. Yang PC , Liu T, Wang CS, Zhang NZ, Tao ZD. Active ion secretion and permeability of rabbit maxillary sinus epithelium, impact of staphylococcal enterotoxin B. Otolaryngol Head Neck Surg 2000; 123: 120-123. 　 　

175. Benjamin MA, McKay DM, Yang PC, Cameron H, Perdue MH. Glucagon-like peptide-2 enhances intestinal epithelial barrier function of both transcellular and paracellular pathways in the mouse. Gut 2000; 47: 112-119 　 　

176. Santos J, Benjamin M, Yang PC, Prior T, Perdue MH. Chronic stress impairs rat growth and jejunal epithelial barrier function: role of mast cells. Am J Physiol Gastrointest Liver Physiol 2000, 278: G847-G854. 　 　

177. Yang PC , Berin MC, Perdue MH. Enhanced antigen transport across rat tracheal epithelium induced by sensitization and mast cell activation. J Immunol 1999, 163: 2769-2776. 　 　

178. Santos, J, Saunders PR, Hanssen NPM, Yang PC, Yates D, Groot JA, Perdue MH. Corticotropin-releasing hormone mimics stress-induced colonic epithelial pathophysiology in the rat. Am J Physiol 1999, 277: G391-G399. 　 　

179. Berin MC, Yang PC, Ciok L, Waserman S, Perdue MH. Role for IL-4 in macromolecular transport across human intestinal epithelium. Am J Physiol 1999, 276: C1046-C1052 　 　

180. Yang PC , Liu T, Zhang TY and Fan DS. Effect of substance P on the short-circuit current of rat nasal mucosal epithelium. Ann Otol Rhinol Laryngol 1998, 107: 675-679. 　 　

181. Berin MC, Kiliaan AJ, Yang PC, Groot JA, Kitamura Y and Perdue M. The influence of mast cells on pathways of transepithelial antigen transport in rat intestine. J Immunology 1998, 161: 2561-2566. 　 　

182. Lu J,. Philpott DJ,  Saunders PR, Perdue MH, Yang PC, and McKay DM. Epithelial transport and barrier abnormalities evoked by superantigen-activated immune cells are inhibited by IL-10, but not IL-4. J Pharmacol Exp Therap 1998, 287, 126-138. 　 　

183. Yang PC , Liu T, Zhang TY, Fan DS. The effect of the H2 antagonist cimetidine on the numbers of CD4+ and CD8+ cells in the nasal mucosa of patients with allergic rhinitis. Clin Otolaryngol (UK) 1997, 22: 93-95. 　 　

184. Berin MC, Kiliaan AJ, Yang PC, Groot JA, Taminiau JAJM, Perdue MH. Rapid transepithelial antigen transport in rat jejunum: impact of sensitization and the hypersensitivity reaction. Gastraenterology 1997, 113: 856-864. 　 　

185. Yang PC , Okuda M, Pawankar R, Aihara K. Electron microscopical studies of the cell population in nasal secretions. Rhinology 1995, 33: 70-77. 　 　

186. Yang PC , Zeng HY, Zhang TY, Fan DS. Investigation on induction of auto-anti-IgE antibody and its inhibitory effect on serum IgE antibody levels in type I allergic reaction animal model. Chinese J  Immunol 1996, 12: 231-233. 　 　

187. Yang PC , Fan DS, Zhang TY, Wang CS. Electrical activity of vagal nucleus when trigeminal nasal afferents stimulated by histamine? Chinese J Otolaryngol 1996, 31: 159-161 　 　

188. Yang PC , Li XQ. Induction of endogenous anti-IgE antibody of nasal mucosa and its inhibitive effects on IgE level. Chinese J Otolaryngol 1995, 30: 27-29. 　 　

189. Yang PC . Investigation on etiology of abnormal ratio of CD4/CD8 cells in allergic nasal mucosal epithelium. Chinese J Otolaryngol 1994, 29: 286-288. 　 　

190. Yang PC , Zeng HY. Inducement of endogenous anti-IgE and its suppressive effects on serum IgE level. Chinese J Immunol and Microbiol 1994, 14: 407-410. 　 　

191. Yang PC ,Wang CS, Zhang NZ. Clinical outcomes after endoscopic sinus surgery. Arch Otol Head Neck Surg 1994, 1: 84-88. 　 　

192. Yang PC , Li WK, Wang CS, Bai EX. Assessment of lower airway involvement in chronic rhinosinusitis. Bulletin Shanxi Medical College 1994, 25: 9-11. 　 　

193. Yang PC , Tao ZD, Cao ZZ, Xiao JY. Chronic sinusitis: characterization of cellular influx and inflammatory mediators in sinus lavage fluid. Chinese Clin Internal Med 1993, 9: 271-273.       　 　

194. Yang PC , Liu T, Fan DS. Assessment of inflammation in noninfectious chronic maxillary sinusitis.  Chinese J Otolaryngol 1995; 26: 156-158. 　 　

195. Yang PC , Liu T, Zhang TY. The effect of sinus surgery in the treatment of vasomotor rhinitis. Chinese J Otolaryngol 1994; 25: 299-301. 　 　

196. Okuda M, Yang PC, Parwankar R, Onishi M, Okubo K. Electron microscopic analysis of allergic nasal secretion. Immunol Allergy 1994; 12: 164-165. 　 　

197. Yang PC , Zhang TY, Fan DS. A mechanism of antigen-induced goblet cell degranulation in the nasal epithelium. Clin J Otolaryngol 1993; 9: 34-36. 　 　

198. Yang PC , Tian DF, Cao ZZ. Histamine receptor is upregulated in seasonal allergic rhinitis. Chinese J of Pharmacol 1990; 18: 433-436. 　 　

199. Yang PC , Tao ZD, Tian D. Further improvement of quality of life by Historest in perennial allergic rhinitis as a function of treatment duration. Chinese J Otolaryngol 1993; 24: 108-111. 　 　

200. Yang PC , Tao ZD, Cao ZZ. The effect of Historest in the treatment of the patients with allergic rhinitis, a double-blind, randomized clinical trial from a multi-clinical research center. Clin J Otolaryngol 1992; 8: 334-337. 　 　

201. Yang PC , Tao ZD, Cao ZZ, Xiao JY. Does Historest affect human nasal cilial movement? Clin J Otolaryngol 1989; 5: 129-131. 　 　

202. Yang PC , Tao ZD, Tian DF, Cao ZZ. The effect of Historest on rat’s nasal mucosal permeability cause by histamine nasal challenge. Chinese J Otolaryngol 1988; 19: 2-5. 　 　

203. Yang PC , Li WC, Wang CS, Bai NX. The blocking effect of H1 and H2 histamine antagonist on nasal secretions of the patients with allergic rhinits. Chinese J Otolaryngol 1987; 18: 110-113. 　 　

204. Yang PC , Li WC, Wang CS, Bai NX. H1 and H2 receptors on human nasal mucosa, an immunohistochemical study. Clin J Otolaryngol 1986; 2: 34-36.