NAME: Gong, Liyun

POSITION TITLE: Associate Professor of Biochemistry and Molecular Biology; Shenzhen University School of Medicine

EDUCATION/TRAINING

A.   Personal Statement

To date, the majority of metastasis research has focused on somatic alterations in tumor cells. However, in despite decades of research and the identification of a large number of tumor cell-autonomous metastasis-associated genes, the process of metastasis is still largely unclear. Furthermore, it is unclear whether metastasis is driven primarily by somatic events in the tumor or functional variation at the level of the whole organism. Cancer cells must acquire diverse biological capabilities in their transition to malignancy; these cells are characterized by highly unstable genomes. Chromosomal alterations, DNA mutations and aberrant epigenetic modifications may coordinate to activate oncogenes and/or inactivate tumor suppressor genes, and together serve as the driving force toward tumorigenesis. My current research interests focus on the identification of the driving events or factors that are essential for the development of the effective and targeted therapeutic agents against cancers.

B.   Positions and Honors

Positions and Employment

07/199 7 – 07 / 2000         Teaching Assistant Professor, Department of Immunology and Microbiology, Dalian Medical University, Dalian, China, Program in Cell Immunology

0 7 /20 03 – 07/20 05        Lecturer, Teaching Assistant Professor, Department of Immunology and Microbiology, Dalian medical University, Dalian, China, Program in Molecular Immunology

;

05/20 08 –present         Associate Professor, Department of Biochemistry and Molecular Biology, Shenzhen University Health Science Center, Shenzhen, China, Program in Cancer Biology

0 3 /201 5 – 03/2016       Guest Researcher, Laboratory of Cancer Biology and Genetics (LCBG), Center for Cancer Research, National (CCR), Cancer Institute (NCI), National institute of health (NIH), Program in inherited susceptibility in tumor metastasis

Honors

01/2017 – 12/2021            High level reserve talents in Shenzhen（20170126181H)

C.   Research Support

NSFC (China) key project (31530016)                01/01/2012 to 12/31/2014

Gong LY, PI                                                                     ￥240,000

The mechanism of SPHK1 anti-apoptosis in glioma

Shenzhen Science and Technology Innovation Commission grant (JCYJ20170302144320949)                                                                                                             07/01/2017 to 06/30/2019

Gong LY, PI                                                                       ￥400,000

Mechanistic investigation of SRPK1 promote Gefitinb resistance in NSCLC

D.   Peer-reviewed publications (*: corresponding author/ first author)

[1] LiYun Gong*, JunWei Song, Xi Lin, FaKai Wei, CuiCui Zhang, ZiMei Wang, JinRong Zhu,Shu Wu, Yu Chen, Jin Liang, Xiao-Yuan Fu, Jun-Qiang Lu, Chun-Hui Zhou, and Li-Bing Song.Serine-Arginine Protein Kinase 1 Promotes a Cancer Stem Cell-like Phenotype through Activation of Wnt/β-catenin Signaling in NSCLC. Journal of Pathology 2016; 240: 184-196 (IF=6.89)

[2] Xing-hua Li, Jun-wei Song, Jun-ling Liu, Shu Wu, Le-shi Wang, Li-yun Gong* and Xi Lin.Serine-arginine protein kinase 1 is associated with breast cancer progression and poor patient survival Med Oncol (2014) 31:83 DOI 10.1007/s12032-014-0083-8 (IF=2.63)

[3] Liu J, Yin X, Liu B, Zheng H, Zhou G, Gong L, Li M, Li X, Wang Y, Hu J, Krishnan V,Zhou Z, Wang Z. HP1α mediates defective heterochromatin repair and accelerates senescence in Zmpste24-deficient cells. Cell Cycle. 2014, 14;13(8). (IF=3.53)

[4] Chun-Hui Zhou, Li-Ping Ye, Yan Li, Xin-Yin Zhang, Xin-Yu Xu, Li-Yun Gong* Clinical significance of SOX9 in human non-small cell lung cancer progression and overall patient survival .Journal of Experimental & Clinical Cancer Research 2012, 31:18 (IF=5.189)

[5] Jun Li*, Li-Yun Gong*, Li-Bing Song*, Li-Li Jiang, Li-Ping Liu, Jueheng, Wu,Jie Yuan, Jun-Chao Cai, Mian He, Lan Wang, Musheng Zeng, Shi-Yuan Cheng, and Mengfeng Li. Oncoprotein Bmi-1 Renders Apoptotic Resistance to Glioma Cells through Activation of the IKK-Nuclear Factor-κB Pathway. The American Journal of Pathology, 2010 February Vol.176, No.2:699-709 (IF=4.05)

[6] Li J*, Guan HY*, Gong LY*, Song LB, Zhang N, Wu J, Yuan J, Zheng YJ, Huang ZS, Li M. Clinical significance of sphingosine kinase-1 expression in human astrocytomas progression and overall patient survival. Clin Cancer Res. 2008 Nov1; 14(21):6996-7003 (IF=9.6)

[7] Li J*, Zhang N*, Song LB*, Liao WT, Jiang LL, Gong LY, Wu J, Yuan J, Zhang HZ, Zeng MS, Li M. Astrocyte elevated gene-1 is a novel prognostic marker for breast cancer progression and overall patient survival Clinical Cancer Research. (IF=9.6) 2008; 14(11):3319-26.