NAME: Chen, Jiajie

POSITION TITLE: Assistant Professor, Department of Biochemistry and Molecular Biology, Shenzhen University School of Medicine

EDUCATION/TRAINING

A.   Personal Statement

I received my doctorate degree in Molecular Medicine from Sun Yat-sen University in 2013, where I studied molecular targeted treatments for leukemia. I then joined in the Third Affiliated Hospital of Sun Yat-sen University (Guangdong Province Key Laboratory for Liver Research), where I conducted postdoctoral research regarding the impact of the tumor microenvironment on transformation of liver cancer stem cells. In 2015, I joined the Institute of Molecular Medicine at Shenzhen University, where I studied the role of cancer stem cells in cancer prevention and treatment. In 2017, I joined the laboratory of Prof. Ji Kunmei where I conduct basic research on the mechanisms of allergens and allergic diseases. I have published 23 SCI articles, and preside over five research projects (of which one is complete and four are ongoing).

B.   Positions and Honors

Positions and Employment

12 /201 5 – 10 /2017      Assistant Professor, Institute of Molecular Medicine, Shenzhen University School of Medicine, Shenzhen, China

11 /2017 – present       Assistant Professor, Department of Biochemistry and Molecular Biology, Shenzhen University, Shenzhen, China

Other Experience and Honors

1.    R eview er , Oncology Letters (IF: 1.39 ): 20 15 -present

2.    R eview er , International Journal of Oncology (IF: 3.079 ): 20 15 -present

C.   Contributions to Science

1.    Basic research: allergen and allergic disease

2.    Targeting cancer stem cells in cancer prevention and treatment

D.   Research Support

Ongoing Research Support

1. NSFC (China) key project (81602595)                 01/01/2017 to 12/31/2019

Jiajie Chen, PI                                                              ￥170,000 (direct cost)

STAT3/CDK6 pathway regulates the quiescence exit and self renewal in liver cancer stem cells

2. The PhD Start-up Fund of Natural Science Foundation of Guangdong Province (2015A030310191)                                                                                                       08/01/2015 to 07/31/2018

Jia jie Chen, PI                                                                   ￥100,000

Gap junction intercellular communication between hepatic cancer associated fibroblasts and hepatic cancer cells maintains self-renewal capacity of cancer stem cells

3. Natural Science Foundation of Guangdong Province (2017A020215069)                                                                                                                                                01/01/2017 to 12/31/2018

Jia jie Chen, PI                                                                   ￥100,000

The anti-psychotic drug pimozide inhibits he quiescence exit and prevents the occurrence of liver cancer

4. Shenzhen University Research Program (2016088)     08/01/2016 to 08/31/2018

Jiajie Chen, PI                                                                            ￥60,000

STAT3/CDK6 pathway regulates the quiescence exit in liver cancer stem cells

Completed Research Support

1.    Chinese Postdoctoral Science Foundation (2014M562239)             09/01/2014 to 10/07/2015

Jia jie Chen, PI                                                                                        ￥50,000

Gap junction intercellular communication between hepatic cancer associated fibroblasts and hepatic cancer cells maintains self-renewal capacity of cancer stem cells

E.    Peer-reviewed publications (*: corresponding author , ^# : co-first author)

1.      Chen JJ^#, Cai N^#, Chen GZ#, Jia CC, Qiu DB, Du C, Liu W, Yang Y, Long ZJ*, Zhang Q*, The Neuroleptic Drug Pimozide Inhibits Stem-like Cell Maintenance and Tumorigenicity in Hepatocellular Carcinoma. Oncotarget. 2017, 8(11):17593-17609.

2. Chen JJ *^#, Zhou W^#, Cai N, Chang G*. In Vivo Murine Model of Leukemia Cell-Induced Spinal Bone Destruction. Biomed Res Int. 2017;2017:3521481.

3.      Cai N^#, Zhou W^#, Ye LL, Chen J, Liang QN, Chang G*, Chen JJ*. The STAT3 inhibitor pimozide impedes cell proliferation and induces ROS generation in human osteosarcoma by suppressing catalase expression. Am J Transl Res. 2017, 9(8):3853-3866.

4.      Gao S^#, Hou X^#, Jiang Y, Xu Z, Cai T, Chen JJ*, Chang G*. Integrated analysis of hematopoietic differentiation outcomes and molecular characterization reveals unbiased differentiation capacity and minor transcriptional memory in HPC/HSC-iPSCs. Stem Cell Res Ther. 2017, 8(1):13.

5.      Cai N^#, Xie SJ^#, Qiu DB, Du C, Liu W, Chen JJ*, Zhang Q*. Potential effects of α-mangostin in the prevention and treatment of hepatocellular carcinoma. Journal of Functional Foods. 2016, 26: 309–18.

6.      Zhou W^#, Chen MK^#, Yu HT, Zhong ZH, Cai N, Chen GZ, Zhang P*, Chen JJ*. The antipsychotic drug pimozide inhibits cell growth in prostate cancer through suppression of STAT3 activation. Int J Oncol. 2016, 48(1):322-8.

7.      Wang LX^#, Wang JD^#, Chen JJ^#, Long B, Liu LL, Tu XX, Luo Y, Hu Y, Lin DJ, Lu G*, Long ZJ*, Liu Q*. Aurora A Kinase Inhibitor AKI603 Induces Cellular Senescence in Chronic Myeloid Leukemia Cells Harboring T315I Mutation. Scientific Reports. 2016; 6:35533.

8.      Chen JJ^#, Long ZJ^#, Xu DF^#, Xiao RZ, Liu LL, Xu ZF, Qiu SX*, Lin DJ*, Liu Q*. Inhibition of Autophagy Augments the Anticancer Activity of α-Mangostin in Chronic Myeloid Leukemia Cells. Leukemia & Lymphoma. 2014, 55(3):628-638.

9.      Pan XN^#, Chen JJ^#, Wang LX, Xiao RZ, Liu LL, Fang ZG, Liu Q, Long ZJ*, Lin DJ*. Inhibition of c-Myc Overcomes Cytotoxic Drug Resistance in Acute Myeloid Leukemia Cells by Promoting Differentiation. PLoS ONE, 2014, 9(8): e105381.

10.   Chen JJ^#, Xia LX^#, Wu XL, Yang SH, Ji KM*, Liu ZG*, Tang MJ and Gao C. A practical test system for sensitive, rapid screening and authentication of peanut allergens in imported and exported food products in Chinese Customs. Food Control. 2012, 23(1): 154-158.

11.   Wei PF, Cai ZL, Hua JW, Yu WJ, Chen JJ, Kang K, Qiu CL, Ye LL, Hu JY, Ji KM*. Pains and Gains from China's Experiences with Emerging Epidemics: From SARS to H7N9. Biomed Res Int. 2016, 2016:5717108.

12.   Wu X^#, Yang N^#, Zhou WH^#, Xu J, Chen JJ, Zheng FM, Long ZJ, Yue CF, Ai KX, Liu LL, Wan XY* and Liu Q*. Up-regulation of p21 inhibits TRAIL mediated extrinsic apoptosis, contributing resistance to SAHA in acute myeloid leukemia cells. Cell Physiol Biochem, 2014, 34:506-518.

13.   Liu LL^#, Long ZJ^#, Wang LX, Zheng FM, Fang ZG, Yan M, Xu DF, Chen JJ, Wang SW, Lin DJ* and Liu Q*. Inhibition of mTOR pathway sensitizes acute myeloid leukemia cells to aurora inhibitors by suppression of glycolytic metabolism. Mol Cancer Res. 2013, 11(11):1326-1336.

14.   Ji KM, Chen JJ, Gao C, Liu XY, Xia LX*, Liu ZG*, Li L and Yang SH. A two-site monoclonal antibody immunochromatography assay for rapid detection of peanut allergen Ara h1 in Chinese imported and exported foods. Food Chemistry. 2011, 129(2): 541-545.

15.   Xu DR*^#, Huang S^#, Long ZJ#, Chen JJ, Zou ZZ, Li J, Lin DJ and Liu Q*. Inhibition of mitotic kinase Aurora suppresses Akt-1 activation and induces apoptotic cell death in all-trans retinoid acid-resistant acute promyelocytic leukemia cells. J. Transl. Med. 2011, 9: 74.

16.   Zhan ZK, Ji KM, Liu ZG*, Li M, Chen JJ, Li JN and Qiu S. Monoclonal antibodies against recombinant Der f 3 reveal localization of Der f 3 in the gut and faecal pellets of Dermatophagoides farinae. Exp Appl Acarol, 2010, 52(1): 63-71.

17.   Wu XL, Wu H, Xia LX, Ji KM*, Liu ZG*, Chen JJ, Hu DS, Gao C and Wu Y. Socio-technical innovations for total food chain safety during the 2008 Beijing Olympics and Paralympics and beyond. Trends in Food Science & Technology, 2010, 21(1): 44-51.

18.   Ji KM, Chen JJ, Li M, Liu ZG*, Xia LX, Wang CB, Wu XL. Comments on serious anaphylaxis caused by nine Chinese herbal injections used to treat common colds and upper respiratory tract infections. Regulatory Toxicology & Pharmacology. 2009, 55(2): 134-138.

19.   Ji KM, Chen JJ, Li M, Liu ZG*, Wang CB, Zhan ZK, Wu XL, Xia QY. Anaphylactic shock and lethal anaphylaxis caused by food consumption in China. Trends in Food Science & Technology. 2009, 20(5): 227-231.

20.   Ji KM, Li M, Chen JJ, Zhan ZK, Liu ZG. Anaphylactic shock and lethal anaphylaxis caused by Houttuynia Cordata injection, a herbal treatment in China. Allergy. 2009, 64(5): 816-817.

21.   Li M, Ji KM, Liu ZG*, Wang CB, Zhan ZK, Chen JJ, Wu XL. Food allergen labeling during the 2008 Beijing Olympics and Paralympics and beyond. Trends in Food Science & Technology. 2009, 20 (2): 100-102.

22.   Liu ZG*, Xia L, Wu YL, Chen JJ, Roux KH. Identification and characterization of an arginine kinase as a major allergen from Silkworm (Bombyx mori) larvae. Int Arch Allergy Immunol. 2009, 150(1): 8-14.

23.   Ji KM, Zhan ZK, Chen JJ, Liu ZG*. Anaphylactic shock caused by silkworm pupa consumption in China. Allergy. 2008, 63(10):1407-8.