BIOGRAPHICAL SKETCH 　 　

Provide the following information for the Senior/key personnel and other significant contributors.
Follow this format for each person.   DO NOT EXCEED FIVE PAGES. 　 　

NAME: Qian, Minxian 　 　

POSITION TITLE: Associate Professor; Shenzhen University School of Medicine 　 　

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable. Add/delete rows as necessary.) 　 　

A.  Personal Statement 　 　

My research focuses on the molecular mechanisms of aging and aging-related diseases. My lab is actively exploring the interplay between DNA damage signals and age-related metabolic reprogramming, and the role of sirtuins in DNA repair and age-onset epigenetic alteration. In particular, we are screening for compounds from natural products that may alleviate aging-related diseases and promote longevity  u sing progeroid mouse models . My research has been continuously supported by the National Natural Science Foundation in China (NSFC). 　 　

B.  Research Support 　 　

Ongoing Research Support 　 　

NSFC (81501206 ) 01/01/20 16  to 12/31/20 18 　 　

Minxian Qian, PI ￥ 21 0,000 　 　

Proteomic analysis   of laminopathy-based premature aging 　 　

Natural Science Foundation of Guangdong Province (2016A030310064) 06/01/20 16  to 06/01/20 19 　 　

Minxian Qian, PI ￥ 10 0,000 　 　

Mechanistic investigation of the role of SIRT6-mediated ATM activation in DNA damage response 　 　

Completed Research Support 　 　

Shenzhen Science and Technology Innovation Commission grant (JCYJ20150525092941002) 09/25/2017 to 09/25/2017 　 　

Minxian Qian, PI ￥ 300,000 　 　 　 　

C.  Peer-reviewed publications (*: corresponding author) 　 　

1.  Min-Xian Qian ¹ , Ye Pang ¹ , Cui Hua Liu ¹ , Kousuke Haratake ¹ , Bo-Yu Du ¹ , Dan-Yang Ji ¹ , Guang-Fei Wang, Qian-Qian Zhu, Wei Song, et al., Linfang Wang, Alfred L. Goldberg, Yan Shen, and Xiao-Bo Qiu*（2013）Acetylation-Mediated Proteasomal Degradation of Core Hist ones during DNA Repair and Spermatogenesis. Cell. 153, 1012–1024. 　 　

2.  Minxian Qian ¹ , Zuojun Liu ¹ , Linyuan Peng, Fanbiao Meng, Xiaolong Tang, Ying Ao, Lei Shi, Mingyan Zhou, Ming Wang, Baoming Qin, Xinyue Cao, Zimei Wang, Zhongjun Zhou, Baohua Liu*  Boosting ATM activity alleviates ageing and extends lifespan in a mouse model of progeria.  eLife. 2018;7:e34836 　 　

3.  Tang X, Shi L, Xie N, Liu Z, Qian M , Meng F, Xu Q, Zhou M, Cao X, Zhu WG, Liu B*  SIRT7 antagonizes TGF-β signaling and inhibits breast cancer metastasis. Nature Communications. 2017 Aug 22;8(1):318..