Name：Sisi Li

Position：Professor

E-mail：liss@szu.edu.cn

Personal Statement:

Dr. Li Sisi obtained her Ph.D. degree from Fudan University in 2013, and joined the Memorial Sloan Kettering Cancer Center in New York for postdoctoral research. From 2016 to 2021, she was an Associate Professor at the Department of Biology at Southern University of Science and Technology, and in 2021, she joined the Carlson International Cancer Center at Shenzhen University. She was awarded the National Science Foundation for Outstanding Young Scholars and Shenzhen Overseas high-Caliber talent.

In recent years, Dr. Li has focused on the mechanisms of RNA post-transcriptional regulation. Using various biological research methods, she has established a joint system from the chemical structure of RNA to the regulation mechanism and physiological function of RNA with relevant proteins, and finally to RNA drug development. In the past five years, she has published over ten academic papers as the first or corresponding author in high-profile journals such as Science, Nature Communications, and PNAS. Some of her research achievements have received specialized reviews and recommendations from academic media such as Faculty Opinion, and she has also served as a reviewer for several well-known journals.

Research Interests:

RNA post-transcriptional regulation

Epigenetics

Research Projects:

1.National Science Foundation for Outstanding Young Scholars, 32222039, 2023.01-2025.12.

2.Natural Science Foundation of China: 31870755, 2019.01-2022.12.

Participate:

3.Guangdong Special Project - Introduction of Innovative Science Research

Teams, 2016ZT06S172, 2017.06-2022.05.

4.Shenzhen Peacock Team, KYTDPT20181011104005, 2017.06-2022.05.

5.Selected Peer-reviewed Publications:（no more than 5）

1.Li S* and Du J*. Making a 6mA demethylase. Nat Chem Biol. 2022,18 :683-684.

2.Wang Q#, Xue Y#, Zhang L#, Zhong Z, Feng S, Wang C, Xiao L, Yang Z, Harris CJ, Wu Z, Zhai J, Yang M, Li S*, Jacobsen SE*, Du J*. Mechanism of siRNA production by a plant Dicer-RNA complex in dicing-competent conformation. Science. 2021, 374: 1152-1157.

3.Huang X#, Hu H#, Webster A, Zou F, Du J, Patel DJ, Toth KF, Aravin AA*, Li S*. Binding of guide piRNA triggers methylation of the unstructured N-terminal region of Aub leading to assembly of the piRNA amplification complex. Nat Commun. 2021, 12: 4061.

4.Hou Y#, Wu B#, Sun J#, Gao Y#, Nie H, Nie Z, Quan S, Wang Y*, Cao X*, Li S*. Arabidopsis CPSF30-L regulates nitrate signaling by controlling alternative polyadenylation through binding to m6A. Mol Plant. 2021, 14: 688-699.

5.Zou F#, Tu R#, Duan B#, Yang Z, Ping Z, Song X, Chen S, Price A, Li H, Scott A, Perera A, Li S*, Xie T*. Drosophila YBX1 homolog YPS promotes ovarian germ line stem cell development by preferentially recognizing 5-methylcytosine RNAs. PNAS. 2020, 117: 3603-3609.