NAME: Yu, Huimin

POSITION TITLE: Research Associate, School of Medicine, Shenzhen University

EDUCATION/TRAINING

A.   Personal Statement

My research interests lie in the theoretical basis of Traditional Chinese Medicine (TCM), anti-tumor research and TCM, application research on TCM in neurodegenerative diseases and research on the prevention and treatment of Helicobacter pylori with TCM. I have obtained certain achievements in modern research on the theory of TCM, and developmental research on antitumor drugs. I have published 38 articles in core periodicals, including six SCI articles.

I am currently engaged in a series of research on classical Zuojin prescription, including: prescription optimization and drug compatibility, prescription pharmacological mechanisms from a molecular biology perspective, and the prescription material based on Chinese Medicine Chemistry. The aim is to increase the additional indications of Zuojin prescription, and provide a solid experimental basis for developing a compound preparation of Zuojinthat is safe, stable and controlled, and to develop a new drug that has a clear pharmacodynamic material basis and distinct mechanisms. This research will have an important role in the prosperity of TCM industry and social economic development.

B.   Positions and Honors

Positions and Employment

2008-present, Research Associate, School of Medicine, Shenzhen University

2006-2008, Overall supervisor, Shenzhen Institute of the Hong Kong Polytechnic University

2002-2003, Guangdong Institute of Traditional Chinese Medicine

1994-1999, Pharmacy Department, Traditional Chinese Medicine Hospital of the Xinjiang

Uygur Autonomous Region

C.   Research Support

Preliminary Special Research of plan 973. Study on Pattern Recognition System of Four Properties of Chinese Medicine based on Apoptosis Expression (2006CB708516) (January 2007 to December 2008.)

Construction Project of basic conditions in Science and Technology, Guangdong Province. Research on apoptosis induced by Zuojin Prescription on gastric cancer in nude mice tumor (January 2010 to December 2011)

Shenzhen funding project of technical research and development funds basic research effort. Research of molecular mechanism and material basis of Zuojin prescription on the inhibition in gastric cancer in nude mice. (January 2010 to December 2012).

Project of Guangdong science and technology planning. Developmental Research of Zuojin prescription on anti-tumor. (January 2012 to December 2014)

Shenzhen funding project of technical research and development funds basic research effort. Study on Pattern Recognition System of Four Properties of Chinese Medicine in sub-cellular based on Thermal dynamics Expression (JC201105170641A) (January 2012 to December 2013)

Special funds of Shenzhen development of strategic emerging industry. Research of cold and hot Properties of Chinese Medicine based on fingerprint of intestinal flora 16 s rDNA in irritable bowel syndrome. (July 2013 to August 2015)

Shenzhen science and technology innovation plan: Research of mechanism of action and material basis of Zuojin prescription on anti Helicobacter pylori infection (March 2018 to March 2000).

D.   Peer-reviewed publications

1. H. M. Yu, et al. Role of the JAK-STAT pathway in protection of hydrogen peroxide preconditioning against apoptosis induced by oxidative stress in PC12 cells, APOPTOSIS 2006, (11) : 931-941.
2. Huimin Yu, et al. JAK-STAT pathway modulates the roles of iNOS and COX-2 in the cytoprotection of early phase of hydrogen peroxide preconditioning against apoptosis induced by oxidative stress. Neurosci Lett, 2012, 529(2): 166-71.
3. Huimin Yu, et al. Neuroprotection against Ab25–35-induced apoptosis by Salvia miltiorrhiza extract in SH-SY5Y cells，Neurochemistry International 2014,75: 89–95.
4. Li-Hua Yao, Hui-Min Yu, et al. Cordycepin Decreases Compound Action Potential Conduction of Frog Sciatic Nerve In Vitro Involving Ca2+-Dependent Mechanisms, Neural Plasticity, 2015, 1–7.
5. Yau Sang CHAN, Huimin YU, et al. Lectin purified from green speckled lentil seeds (Lens culinaris) triggered apoptosis in nasopharyngeal carcinoma cell lines, Chin Med, 2015, 10：1–9.