NAME: Cai, Yi

POSITION TITLE: Assistant Professor, Department of Pathogens, Shenzhen University School of Medicine

EDUCATION/TRAINING

A.   Personal Statement

I am currently an Assistant Professor in the Department of Pathogens, Shenzhen University School of Medicine. My research interests lie in host-pathogen interactions and Tuberculosis (TB) disease progression. I am studying both the bacterial determinants of virulence and the key host determinants of immunity to discover new targets for TB therapy.

B.   Positions and Honors

Positions and Employment

08/2012 – 03/2017      Research Associate, Shenzhen Third People’s Hospital, Shenzhen, China

11/2017 – present       Assistant Professor, Department of Pathogens, Shenzhen University School of Medicine, Shenzhen, China

C.   Research Support

Ongoing Research Support

NSFC (China) (81770013)                                   01/01/2018 to 12/31/2021

Yi Cai, PI                                                                     ￥580,000 (direct cost)

The role of xCT in inhibiting Mycobacterium tuberculosis MSH oxidation in macrophage

Shenzhen Science and Technology Innovation Commission grant (JCYJ20170412101048337)                                                                                                      07/01/2017 to 06/30/2020

Yi Cai, PI                                                                     ￥2,000,000

Screening and Functional Analysis of Mycobacterium tuberculosis Antioxidant Gene Based on Transposon Mutation Sequencing

Completed Research Support

NSFC (China) (81401310)                            01/01/2015 to 12/31/2017

Yi Cai, PI                                                              ￥230,000

The effect of C1q on macrophage during M.tuberculosis infection and its role in TB  immunopathology and disease progression

D.   Peer-reviewed publications (*: corresponding author)

(1)       Cai Y ^# , Yang Q^#, Liao M^#, Wang H^#, Zhang C, Nambi S, Wang W, Zhang M, Wu J, Deng G, Deng Q, Liu H, Zhou B, Jin Q, Feng C, Sassetti S, Wang F^*, Chen X^*, xCT increases tuberculosis susceptibility by regulating antimicrobial function and inflammation, Oncotarget, 2016, 7(21):31001-31013

(2)       Cai Y ^# , Yang Q^#, Tang Y^#, Zhang M, Liu H, Zhang G, Deng Q, Huang J, Gao Z, Zhou B, Feng CG, Chen X^*, Increased Complement C1q Level Marks Active Disease in Human Tuberculosis, PLoS One, 2014, 9(3):e92340.

(3)       Cai Y^#, Fan J^#, Sun S, Wang F, Yang K, Li G^*, Pang Y, Interspecific Interaction Between Spodoptera exigua Multiple Nucleopolyhedrovirus and Microplitis bicoloratus (Hymenoptera: Braconidae: Microgastrina) in Spodoptera exigua (Lepidoptera: Noctuidae) Larvae. Journal of Economic Entomology, 2012, 105(5):1503-1508.

(4)       Cai Y, Long Z, Qiu J, Yuan M, Li G^*,Yang K, An ac34 Deletion Mutant of Autographa californica Nucleopolyhedrovirus Exhibits Delayed Late Gene Expression and a Lack of Virulence In Vivo, Journal of Virology 2012, 86(19):10432-10443.

(5)       Cai Y, Cheng Z, Li C, Wang F, Li G^*, Pang Y, Biological activity of recombinant Spodoptera exigua multicapsid nucleopolyhedrovirus against Spodoptera exigua larvae, Biological Control, 2010, 55(3):178-185.

(6)       Zhang G^#, Liu X^#, Wang W, Cai Y, Li S, Chen Q, Liao M, Zhang M, Zeng G, Zhou B, Feng CG, Chen X^*, Down-regulation of miR-20a-5p triggers cell apoptosis to facilitate mycobacterial clearance through targeting JNK2 in human macrophages, Cell Cycle, 2016, 15(18):2527-2538.

(7)       Yang Q^#, Xu Q^#, Chen Q, Li J, Zhang M, Cai Y, Liu H, Zhou Y, Deng G, Deng Q, Zhou B, Kornfeld H, Chen X^*, Discriminating Active Tuberculosis from Latent Tuberculosis Infection by flow cytometric measurement of CD161-expressing T cells, Scientific Reports 2015, 5:17918.

(8)       Yang Q, Cai Y, Zhao W, Wu F, Zhang M, Luo K, Zhang Y, Liu H, Zhou B, Kornfeld H, Chen X^*, IP-10 and MIG Are Compartmentalized at the Site of Disease during Pleural and Meningeal Tuberculosis and Are Decreased after Antituberculosis Treatment, Clinical and vaccine Immunology, 2014, 21(12): 1635-1644.