BIOGRAPHICAL SKETCH

? ? ?NAME: Fan, Xinmin

POSITION TITLE: Professor of Pathology; Vice Dean for Teaching Affairs, Shenzhen University School of Medicine

EDUCATION/TRAINING

?

A.?? Personal Statement

My long-standing interests fall in clinical pathological diagnoses, especially in surgical pathology and cytopathology of reproductive system. In addition, I have done some research in the molecular mechanisms of cell signaling transduction and tumorigenesis. ?More specifically, we focused on the subject exploring how oncogenic microRNAs and circRNAs regulate critical signaling transduction pathways, such as the Wnt/b-catenin pathway and NF-kB signaling pathway to promote cell survival, proliferation and migration in gastric cancer. ?I have published more than 20 papers in the peer-reviewed professional journals.?

B.? ?Positions and Honors

07/1987 – 8/1989??????? Assistant Professor, Department of Physiology, Beijing Medical University, Beijing, China

07/2003 – 02/2010????? Senior Attending Pathologist, Univ. Of Conn. Health Center, Farmington, CT,USA

03/2010 – present?????? Professor of Pathology, Vice Dean for Teaching Affairs, Shenzhen University, School of Medicine, Shenzhen, China

?

C.?? Peer-reviewed publications (*: corresponding author)

?1. Peng,Y，Zhang,X，Ma,Q，Yan,R，Qin,Y，Zhao,Y，Cheng,Y，Yang,M，Wang,Q，Feng,X，Huang,Y，Huang,W，Zhao,Z，Wang,L，Wei,Y，He,Z，Fan,X，Li,S，Jin,Z*，S.J,Meltzer，MicroRNA-194 activates the Wnt/beta-catenin signaling pathway in gastric cancer by targeting the negative Wnt regulator, SUFU，Cancer letters，385 (2017) 117-127

2. Peng,Y，Zhang,X，Feng,X，Fan,X，Jin,Z*，The crosstalk between microRNAs and the Wnt/beta-catenin signaling pathway in cancer，Oncotarget，2017，8(8):14089-14106

3. Zhang X, Peng Y, Huang Y, Yang M, Yan R, Zhao Y, Cheng Y, Liu X, Deng S, Feng X, Lin H, Yu H, Chen S, Zhao Z, Li S, Li K, Wang L, Wei Y, He Z, Fan X, Meltzer SJ, Li S, Jin Z, SMG-1 inhibition by miR-192/-215 causes epithelial-mesenchymal transition in gastric carcinogenesis via activation of Wnt signaling.Cancer Med. 2017 Dec 13.

??????? 4. Gypenoside L, Isolated from Gynostemma pentaphyllum, Induces Cytoplasmic Vacuolation Death in Hepatocellular Carcinoma Cells through reactive-Oxygen-Species-Mediated Unfolded Protein Response Kai Zheng, Chenghui Liao, Yan Li, Xinmin Fan, Long Fan, Hong Xu, Qiangrong Kang, Yong Zeng, Xuli Wu, Haiqiang Wu, Lizhong Liu, Xiaohua Xiao, Jian Zhang, Yifei Wang, and Zhendan He*,? J. Agric. Food Chem. 2016, 64, 1702?1711

5. Ou Sha, Wenqi Jiang, Miao Xie, Xinmin Fan, Zhigang Liu. Teaching histology and embryology in English in the medical school of Shenzhen. IFAA Aug 2014, Ann Anat

6. Tianshun Xie, Taraneh Afnan-Holmes, Miao Xie, Zhigang Liu, Xinmin Fan, Wing-Hang Kwong, and Ou Sha. Cooperation between Histology and English Teaching Staffs in Shenzhen University, China. IFAA Aug 2014, Ann Anat

7. Automation-assisted cervical cancer screening in manual liquid-based cytology with hematoxylin and eosin staining. Cytometry Part A 12/2013

8. Zhe Jin, Zhenfu Zhao, Yulan Cheng, Ming Dong, Xiaojing Zhang, Liang Wang, Xinmin Fan, Xianling Feng, Yuriko Mori and Stephen J Meltzer. Endoglin Promoter Hypermethylation Identifies a Field Defect in Human Primary Esophageal Cancer. Cancer, 2013 Oct 15;119(20):3604-9.

9. Jin Z (corresponding author), Wang L, Zhang Y, Cheng Y, Gao Y, Feng X, Dong M, Cao Z, Chen S, Yu H, Zhao Z, Zhang X, Liu J, Mori Y, Fan X, Meltzer SJ. MAL hypermethylation is a tissue-specific event that correlates with MAL mRNA expression in esophageal carcinoma. Sci Rep. 2013 Oct 3;3:2838.

10. Jin Z (corresponding author), Feng X, Jian Q, Cheng Y, Gao Y, Zhang X, Wang L, Zhang Y, Huang W, Fan X, Chen S, Yu H, Zhao Z, Dong M, Liu J, Mori Y, Meltzer SJ. Aberrant Methylation of the Ras-related Associated with Diabetes Gene in Human Primary Esophageal Cancer. Anticancer Res. 2013 Nov;33(11):5199-203.

11. Yang C, Mo X, Lv J, Liu X, Yuan M, Dong M, Li L, Luo X, Fan XM, Jin Z, Liu Z Liu J.? Lipopolysaccharide enhances FcsRI-mediated mast cell degranulation by increasing Ca²⁺entry through store-operated Ca²⁺ channels: implications for lipopolysaccharide exacerbating allergic asthma. Exp Physiol? 2012; 97: 1315-1327.

12. Fan XM, Hendly ED, Forehand CJ. Enhanced vascular neuropeptide Y-immunoreactive innervation in two hypertensive rat strains. Hypertension. 1995 Nov;26(5):758-63.

13. Castanon N, Hendley ED, Fan XM. Psychoneuroendocrine profile associated with hypertension or hyperactivity in spontaneously hypertensive rats. Am J Physiol. 1993 Dec;265 (6 Pt 2):R1304-10.

14. Hendley ED, Fan XM. Regional differences in brain norepinephrine and dopamine uptake kinetics in inbred rat strains with hypertension and/or hyperactivity. Brain Res. 1992 Jul 17;586(1):44-52.

15. Lu ZL, Shi YF, Fan XM. Ectopic ACTH syndrome caused by bronchial carcinoid. Zhonghua Nei Ke Za Zhi. 1989 Nov;28(11):642-5, 699.

?

?