NAME: Zheng, Na

POSITION TITLE: Assistant Professor, Department of Pathology, Shenzhen University, Shenzhen, China

EDUCATION/TRAINING

A.   Personal Statement

My long-standing research interests fall in the molecular mechanisms of sudden cardiac death and myocardial injury induced by air pollution or drugs. My research has been supported by the National Natural Science Foundation in China (NSFC) with two grants, and by the China Postdoctoral Science Foundation with one grant, since 2010. I have published >10 papers in professional, peer-reviewed journals recorded by SCI. I have co-edited three English Science Books.

B.   Positions and Honors

Positions and Employment

04/2016 – present       Assistant Professor, Department of Pathology, Shenzhen University, Shenzhen, China

Organizing International Meetings

None.

Other Experience and Honors

None.

C.   Contributions to Science (*: corresponding/co-corresponding author)

A full list of my publications (in a total of 20) is enclosed at the end of this document.

1.    Sudden (cardiac) death and FTIR

Myocardial infarction can be a main cause of sudden cardiac death. The gold standard is pathology, but in negative autopsy cases, such as commotion cordis, pathology may not be informative (Forensic Sci 2013, Med Sci Law 2012). Fourier Transform Infrared Spectroscopy (FTIR) can detect the molecular constitutents and protein conformations in chronic and acute myocardial infarction (J Huazhong Univ Sci Technolog Med Sci  2010). FTIR may thus become a novel technology used in forensic pathology.

1)    Zheng N, Dong M, Liu J. Commotio cordis: a rare catastrophic mechano-electric coupling. In: Giorgio DG, Pietro M. Rare diseases: diagnoses, challenges and developing treatments. New York. Nova Science Publishers, Inc. 2013;1-22.

2)    Zheng N, Liang M, Liu Y, Liu L, Zhu SH*. Commotio cordis--a report of two similar cases. J Forensic Sci. 2013 Jan;58(1):245-7.

3)    Zheng N, Liang M, Liu Y, Ren L, Zhu SH, Liu L*. Imprudent blow, catastrophic consequence: a case of commotio cordis associated with violence. Med Sci Law. 2012 Apr;52(2):119-21

4)    Zheng N, Yang T, Liang M, Zhang H, Li L, Sunnassee A, Liu L*. Characterization of protein in old myocardial infarction by FTIR micro-spectroscopy. J Huazhong Univ Sci Technolog Med Sci. 2010 Aug;30(4):546-50.

2.    Cardiac injury induced by air pollution

With the flourishing research on air pollution, the association between ambient particulate matter exposure and health burden has expanded to not only the morbidity and mortality of respiratory diseases, but also the cardiovascular diseases, such as stoke, myocardial infarction, hypertension, and cardiac arrhythmia. Even in the case of sudden cardiac death, post short-term ultrafine articles exposure may be associated not only with apoptosis, but also with autophagy, which could be regulated by the mTOR pathway.

1)    Zheng N, Man Liang, Ming Dong, Qian Liu, Xin Jiang, Xinmin Fan*, and Jie Liu*. Ambient air pollution: an emerging risk factor for cardiovascular diseases. In: Preshant Kumar. Airborne Particles: origin, emissions and health impacts. New York. Nova Science Publishers, Inc. 2017; 221-238.

2)    Zheng N, Man Liang, Qian Liu, Liang Ren, Xin Jiang, Xinmin Fan*, and Jie Liu*. Improving cardiovascular health: through mitigation of particulate matter exposure. In: Preshant Kumar. Airborne Particles: origin, emissions and health impacts. New York. Nova Science Publishers, Inc. 2017; 291-308.

3)    Zheng N *. Sudden Death and the Effects of Particulate Matter Air Pollution. In: Jiashin Wu, Jessica Wu. Sudden death: Causes, Risk Factors and Prevention. New York. Nova Science Publishers, Inc. 2013;195-210.

D.   Research Support

Ongoing Research Support

None.

Completed Research Support

NSFC (China) (30570371)                                          01/01/2012 to 12/31/2012

Na Zheng, PI                                                                           ￥140,000

Study on the super early stage of sudden cardiac death by spectroscopic pathology

NSFC (China) (81470016)                                          01/01/2015 to 12/31/2016

Na Zheng, PI                                                                      ￥300,000

Effect of the mTOR pathway on the cardiac death induced by short-term exposure of traffic related PM2.5

CPSF (China) (31071190)                                    01/01/2011 to 12/31/2013

Na Zheng, PI                                                                      ￥350,000

Effect the mTOR pathway on the changes of cardiac structure and functions after PM2.5 exposure

E.    Peer-reviewed publications (*: corresponding author)

1.    Zheng N, Man Liang, Ming Dong, Qian Liu, Xin Jiang, Xinmin Fan*, and Jie Liu*. Ambient air pollution: an emerging risk factor for cardiovascular diseases. In: Preshant Kumar. Airborne Particles: origin, emissions and health impacts. New York. Nova Science Publishers, Inc. 2017; 221-238.

2.    Zheng N, Man Liang, Qian Liu, Liang Ren, Xin Jiang, Xinmin Fan*, and Jie Liu*. Improving cardiovascular health: through mitigation of particulate matter exposure. In: Preshant Kumar. Airborne Particles: origin, emissions and health impacts. New York. Nova Science Publishers, Inc. 2017; 291-308.

3.    Zheng N, Dong M, Liu J*. Commotio cordis: a rare catastrophic mechano-electric coupling. In: Giorgio DG, Pietro M. Rare diseases: diagnoses, challenges and developing treatments. New York. Nova Science Publishers, Inc. 2013;1-22.

4.    Zheng N *. Sudden Death and the Effects of Particulate Matter Air Pollution. In: Jiashin Wu, Jessica Wu. Sudden death: Causes, Risk Factors and Prevention. New York. Nova Science Publishers, Inc. 2013;195-210.

5.    Zheng N, Liang M, Zhang HD, Zhu SH, Yang TT, Zhuo L, Wang GF, Liu HX, Liu L*. Fatal extensive bone cement embolism: Histological findings confirmed by Fourier transform infrared spectroscopy. Forensic Sci Int. 2013 Jun 10;299(1-3):e23-5.   

6.    Zheng N, Liang M, Liu Y, Liu L, Zhu SH*. Commotio cordis--a report of two similar cases. J Forensic Sci. 2013 Jan;58(1):245-7.                      

7.    Zheng N, Liang M, Liu Y, Ren L, Zhu SH, Liu L*. Imprudent blow, catastrophic consequence: a case of commotio cordis associated with violence. Med Sci Law. 2012 Apr;52(2):119-21.  

8.    Zheng N*, Zhu S, Liu L, Yu X. Re: The relationship between diabetic retinopathy and serum levels of ischemia-modified albumin and malondialdehyde. Retina. 2011 Oct;31(9):1979.

9.    Zheng N*, Zhu S, Liu L, Yu X. Rat serum albumin is not equal to human serum albumin. Fertil Steril. 2011 Jun 30;95(8):e81.

10.  Zheng N, Yang T, Liang M, Zhang H, Li L, Sunnassee A, Liu L*. Characterization of protein in old myocardial infarction by FTIR micro-spectroscopy. J Huazhong Univ Sci Technolog Med Sci. 2010 Aug;30(4):546-50.               

11.  Liang M, Zhang J, Zheng N, Liu L*. How Postmortem Redistribution of MDMA in Acute Alcohol-MDMA Combined-Use Rats Change under Effects of Alcohol. Sci Rep. 2017 7(1):4038.

12.  Liang M, Zheng N, Cai XY, Liu L, Liu Y*, Jin M*. Determination of Tramadol by Capillary GC-FID and a study of postmortem distribution in rats. Rom J Leg Med. 2011 19(1):45-50.

13.  Yang TT*, Weng SF, Zheng N, Pan QH, Cao HL, Liu L, Zhang HD, Mu da W. Histopathology mapping of biochemical changes in myocardial infarction by Fourier transform infrared spectral imaging. Forensic Sci Int. 2011 Apr 15;207(1-3):e34-9.       

14.  Liu Q, Zhou L, Zheng N, Zhuo L, Liu Y,  Liu L*. Poisoning deaths in China: Type and prevalence detected at the Tongji Forensic Medical Center in Hubei. Forensic Sci Int. 2009 Dec 15;193(1-3):88-94.                  

15.  Dong M, Liao SY, Cheng YW, Zheng N, Ma J, Xiao ZW, Liu Y, Ding W, Liu J*. trans-Polydatin protects the mouse heart against ischemia/reperfusion injury via inhibition of the renin-angiotensin system (RAS) and Rho kinase (ROCK) activity. Food Funct. 2017 8(6):2309-2321.

16.  Liang M, Liu Y, Sunnassee A, Zheng N, Zhang HD, Zhuo L, Liu L*.Refrigeration-induced skull base fracture: three autopsy cases. Rom J Leg Med. 2010 (18):199-202.        

17.  Zhang J, Liu L, Mu J, Yang TT, Zheng N, Dong HM*. Chemical Analysis in the Corpus Callosum Following Traumatic Axonal Injury using Fourier Transform Infrared Microspectroscopy: A Pilot Study. J Forensic Sci. 2015 Nov;60(6):1488-1494.

18.  Liu Q, Sun Q, Liu Y, Zhou L, Zheng N, Liu L*. Bioluminescent assay of microbial ATP in postmortem tissues for the estimation of postmortem interval. J Huazhong Univ Sci Technolog Med Sci. 2009 Dec;29(6):679-83.                    

19.  Yan D, Luo X, Li Y, Liu W, Deng J, Zheng N, Gao K, Huang Q, Liu J*. Effects of advanced glycation end products on calcium handling in cardiomyocytes. Cardiology. 2014;129(2):75-83.                   

20.  Dong M, Ding W, Liao Y, Liu Y, Yan D, Zhang Y, Wang R, Zheng N, Liu S, Liu J*. Polydatin prevents hypertrophy in phenylephrine induced neonatal mouse cardiomyocytes and pressure-overload mouse models. Eur J Pharmacol. 2015 Jan 5;746:186-97.