NAME: Zhang, Xiaojing

POSITION TITLE: Assistant Professor of Pathology, Shenzhen University School of Medicine

EDUCATION/TRAINING

A. Personal Statement

My research interests lie in the molecular mechanisms of tumorigenesis. Since my Ph.D., my research projects have focused on the molecular mechanisms of metastasis in colorectal and stomach carcinomas.  In our research group, we are actively exploring the biomarkers of metastasis in colorectal and stomach carcinomas. Research in my lab has been continuously supported by the National Natural Science Foundation in China (NSFC) and Guangdong Province Science and Technology grants. I have published several papers in professional, peer-reviewed journals.

B. Positions and Employment

Jul. 2006-Aug. 2009:   Department of Histology and Embryology, Xinxiang Medical College, Xinxiang

Jul. 2012-present:       Department of Pathology, Shenzhen University Medical College, Shenzhen, Guangdong

Feb. 2017-Feb. 2018: Biochemistry and Molecular Biology, Penn State University, State College, USA

C.PUBLICATIONS

1. Zhang X , Peng Y, Huang Y, et al. SMG-1 inhibition by miR-192/-215 causes epithelial-mesenchymal transition in gastric carcinogenesis via activation of Wnt signaling. Cancer Med. 2018, 7(1):146-156.

2. Peng,Y ， Zhang,X ， Ma,Q ， et al. MiRNA-194 activates the Wnt/beta-catenin signaling pathway in gastric cancer by targeting the negative Wnt regulator, SUFU, Cancer letters , 2017, 385: 117-127 (co-first)

3. Wang, F. F., Zhang, X. J , Yan, Y. R.,et al.  FBX8 is a metastasis suppressor downstream of miR-223 and targeting mTOR for degradation in colorectal carcinoma , Cancer letters ,  2017, 388: 85~95 (co-first)

4. Peng Y, Zhang X, Feng X, Fan X, Jin Z.The crosstalk between microRNAs and the Wnt/β-catenin signaling pathway in cancer. Oncotarget. 2017 , 8(8):14089- 14106.  (co-first)

5. Liang Wang, Xiaojing Zhang ,  Peng Yin, et al. , Aberrant Methylation of HLTF Gene in HumanEsophageal Cancer, Int J Hum Genet, 2016.9.10, 16(1,2): 70~76

6. Zhang X , Peng Y, Jin Z, et al. Integrated miRNA profiling and bioinformatics  analyses reveal potential causative miRNAs in gastric adenocarcinoma. Oncotarget . 2015, 6(32):32878-89

7. Liang L, Li XZ, Zhang XJ , Lv ZB, et al. MicroRNA-137 ， a HMGA1 target, suppresses cell invasion and metastasis of colorectal carcinoma by directly targeting FMNL2. Gastroenterol , 2013, 144(3):624 （ IF12.03 ） （ co-first ）

8. Zhang XJ , Li N, Li XZ, et al. Low expression level of DAB2IP is associated with poor prognosis of hepatocellular carcinoma. J Gastroenterol Hepatol, 2012,   27(6):1117.

9. Ren XL, Qiao YD, Li JY, Li XM, Zhang D, Zhang XJ, Zhu XH, Zhou WJ, Shi J, Wang W, Liao WT, Ding YQ, Liang L. Cortactin recruits FMNL2 to promote actin  polymerization and endosome motility in invadopodia formation. Cancer Lett. 2018, 419:245-256.

10. Wang F, Qiao Y, Yu J, Ren X, Wang J, Ding Y, Zhang X, Ma W, Ding Y, Liang L. FBX8 Act as an Invasion and metastasis is Suppressor and Correlated with Poor Survival in Hepatocellular Carcinoma. PLoS One. 2013 Jun 27;8(6):e65495.

11.Hou GQ, Sun JC, Zhang XJ, et al. MRI Findings of the Intraspinal Meningeal Melanocytoma Correlation with Histopathological Findings. Am J Neuroradiol, 2012,  33(8): 1525

12.Xianzheng Li, Jianmei Wang, Xiaojing Zhang, Yuanfeng Zeng, Li Liang, Yanqing Ding. Over-expression of RhoGDI2 correlates with tumor progression and poor prognosis in colorectal carcinoma. Ann Surg Oncol, 2012, 19:145 - 153

13. Li YF, Zhu XL, Zeng YF, Wang JM, Zhang XJ, Ding YQ, Liang L. FMNL2 enhances invasion of colorectal carcinoma by inducing epithelial mesenchymal transition. Mol Cancer Res 2010;8(12):1579-90

14. Li Liang, Jian Guan, Yuanfeng Zeng, Jianmei Wang, Xianzheng Li, XiaojingZhang, Yanqing Ding. Down-regulation of formin-like 2 predicts poor prognosis in hepatocellular carcinoma. Human Pathology, 2011; 42: 1603-1612

D. Grants

The molecular mechanism by which FMNL2/Shank2 contributes to the formation of invasive pseudopodia in colorectal carcinoma.

Jan. 2014-Dec. 2016

Sponsor: National Natural Science Foundation

Research on the molecular mechanism of miRNA-340/SMG1 regulated by CircRNA in Stomach carcinoma.

May,2017-May,2020

Sponsor: Nature Science Foundation of Guangdong Province