BIOGRAPHICAL SKETCH 　 　

NAME: Su, Wen 　 　

POSITION TITLE:  Assistant Professor;  Medical Center, Department of Pathology, Shenzhen University School of Medicine 　 　

EDUCATION/TRAINING   (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable. Add/delete rows as necessary.) 　 　

A.  Personal Statement 　 　

My long-standing research interests lie in understanding the molecular mechanisms by which nuclear receptors regulate lipid droplet proteins and metabolic diseases. I am proficient in numerous laboratory techniques, including: lipid droplet purification, in-solution digestion, basic bioinformatics analyses, primary reno-medullary interstitial cells culture, primary hepatocyte culture, transgenic mice breeding, metabolic   phenotype analysis (mice& rat), establishment of NAFLD mouse models. My major research lines focus on: 1. the role of human fatty liver lipid droplets (proteomic and metabonomic studies); and 2. proteomic and metabonomic study of renal medullary interstitial cell lipid droplets. I am supported by the National Natural Science Foundation in China (NSFC). I have published 15 papers in professional, peer-reviewed journals. 　 　 　 　

B.  Positions and Honors 　 　

Positions and Employment 　 　

07/2014 – 02/2017 Postdoctoral Researcher, Shenzhen University, Shenzhen, China 　 　

01/2016 – 12/2016 Visiting Scholar, Center for Nuclear receptor and cell signaling, Houston, TX, USA 　 　

03/2017 – present Associate professor, Shenzhen Health Science Center, Shenzhen University, Shenzhen, China 　 　   

Other Experience and Honors 　 　

1.  Poster Presentation : the 37th Congress of the International Union of Physiological Sciences,  Birmingham, UK , 2013   　 　

2.  Oral Presentation : Young Physiologist Symposium, International Conference for Physiological Sciences,  2012 , Su Zhou, China 　 　

3.  Oral Presentation : Young Physiologist Symposium  (first level scholarship) , 12th National Conference for Lipid and Lipid proteins,  201 4      ， Hang zhou, China 　 　

4.  Outstanding Graduate of Peking University, 2013 　 　

5.  The National Graduate Scholarship, 2012 　 　

6.  Kwang-Hua Scholarship of Peking University 　 　

7.  The First Prize Scholarship of Peking University Health Science Center, 2012-2014 　 　

8.  Patent (China): Youfei Guan, Wen Su.(patent number：201310503889.0) 　 　 　

C.  Research Support 　 　

Ongoing Research Support 　 　

NSFC (China) (81500538 ) 01/01/20 16  to 12/31/20 18 　 　

Wen Su, PI ￥ 180 ,000 (direct cost) 　 　

Lipidomic and Proteomic characterization of lipid droplets from hypertensive rat renal medullary interstitial cells 　 　   

D.  Peer-reviewed publications (*: corresponding author) 　 　

1.  Wen Su #, Yang Wang#, Xiao Jia#, Wenhan Wu, Linghai Li, Xiaodong Tian, Sha Li, Chunjiong Wang, Huamin Xu, Jiaqi Cao, Qifei Han, Shimeng Xu, Yong Chen, Yanfeng Zhong, Xiaoyan Zhang, Pingsheng Liu*, Jan-''ke Gustafsson*, Youfei Guan*. Comparative proteomic study reveals 17β-HSD13 as a pathogenic protein in nonalcoholic fatty liver disease, Proc Natl Acad Sci U S A, 2014, 111(31): 11437-11442. 　 　

2.  Yi-fei Miao#, Wen Su #, Yu-bing Dai, Wan-fu Wu, Bo Huang, Rodrigo P.A. Barros, Hao Nguyen, Laure Maneix, Youfei Guan, Margaret Warner*, Jan-Ake Gustafsson*.An ERβ agonist induces browning of subcutaneous abdominal fat pad in obese female mice, Scientific Reports, 2016, 6:38579. 　 　

3.  Wen Su , Shi-zheng Huang, Min Gao, Xiao-mu Kong, Jan-Ake Gustafsson, Su-juan Xu, Bing Wang, Feng Zheng, Nan-ping Wang, You-fei Guan, Xiao-Yan Zhang. Liver X Receptor β (LXRβ) Increases AQP2 Protein Level via a Post-transcriptional Mechanism in Renal Collecting Ducts. Am J Physiol Renal Physiol, 2017 Apr 1;312(4):F619-F628. 　 　

4.  Su Wen #, Peng Jun#, Li Sha, Dai Yubing, Wang Chunjiong, Xu Hu, Gao Min, Ruan Xiongzhong, Gustafsson Jan-''ke, Guan Youfei, Zhang Xiaoyan. Liver X receptor α induces 17β-hydroxysteroid dehydrogenase-13 expression through SREBP-1c. Am J Physiol Endocrinol Metab. 2017 Apr 1;312 (4):E357-E367. 　 　

5.  Su Wen , Cao Rong, He Yongcheng, Guan Youfei, Ruan Xiongzhong. Crosstalk of Hyperglycemia and Dyslipidemia in Diabetic Kidney Disease.   Kidney Dis (Basel). 2017 Dec;3(4):171-180. 　 　

6.  Xiaoyan Zhang, Sha Li, Yunfeng Zhou Wen Su , Xiongzhong Ruan, Bing Wang, Feng Zheng, Margaret Warner, Jan-''ke Gustafsson, and Youfei Guan. Ablation of cytochrome P450 omega-hydroxylase 4A14 gene attenuates hepatic steatosis and fibrosis.   Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):3181-3185. 　 　

7.  Bo Huang, Ryan Butler, Yifei Miao, Yubing Dai, Wanfu Wu, Wen Su , Yoshiaki Fujii-Kuriyama, Margaret Warner, and Jan-''ke Gustafsson. Dysregulation of Notch and ERα signaling in AhR-/- male mice.   Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):7614-9. 　 　

8.  Yu-bing Dai,a Yi-fei Miao, Wan-fu Wu, Yu Li, Francesca D'Errico, Wen Su , Alan R. Burns, Bo Huang, Laure Maneix, Margaret Warner, and Jan-''ke Gustafsson. Ablation of Liver X receptors α and β leads to spontaneous peripheral squamous cell lung cancer in mice. Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):7614-9. 　 　

9.  Wan-fu Wu, Laure Maneix, Jose Insunza, Ivan Nalvarte, Per Antonson, Juha Kere, Nancy Yiu-Lin Yu, Virpi Tohonen, Shintaro Katayama, Elisabet Einarsdottir, Kaarel Krjutskov, Yu-bing Dai, Bo Huang, Wen Su , Margaret Warner, and Jan-''ke Gustafsson. Estrogen receptor β, a regulator of androgen receptor signaling in the mouse ventral prostate.   Proc Natl Acad Sci U S A. 2017 May 9;114(19):E3816-E3822. 　 　

10.  Yunfeng Zhou, Jingwei Yu, Jia Liu, Rong Cao, Wen Su , Sha Li, Shiqi Ye, Chenggang Zhu, Xiaolin Zhang, Hu Xu, Hua Chen, Xiaoyan Zhang, Youfei Guan . Induction of cytochrome P450 4A14 contributes to angiotensin II-induced renal fibrosis in mice. Biochim Biophys Acta. 2018 Mar; 1864(3):860-870. 　 　

11.  Chunjiong Wang, Yujing Chi, Jing Li, Sha Li, Wen Su . FAM3A activates PI3K   p110α/Akt signaling to ameliorate hepatic gluconeogenesis and lipogenesis.Hepatology,2013; 　 　

12.  Zhang Xiaoyan, Liu Jia, Su Wen , et al. Lxr activation increases hepatic fatty acid   desaturation by the induction of scd1 expression through an   lxralpha-srebp1c-dependent mechanism. J Diabetes, 2013; 　 　

13.  Senfeng Zheng, Liu Jia, Qifei Han, Shizheng HUANG, Wen Su . Metformin induces renal   medullary interstitial cell apoptosis in type 2 diabetic mice.J Diabetes, 2013; 　 　

14.  YF Zhou, Sha Li, Wen Su . Effect of diets with different fat content on   metabolic syndrome of rats and mice.Basic & Clinical Medicine. 2012,32 (3) 　 　

15.  Su Wen , Xu Huamin, Kang Jihogn, Guan Youfei. The function of 17beta-hydroxysteroid dehydrogenase family.   Sheng Li Ke Xue Jin Zhan. 2014 Feb;45(1):27-31.