NAME: Wang, Gang

POSITION TITLE: Lecturer, Shenzhen University School of Medicine

EDUCATION/TRAINING

A.   Personal Statement

My research focuses on cardiac fibrosis and cardiac hypertrophy. I am currently the PI of a National Natural Science Foundation project and a Guangdong Natural Science Foundation project . I have published 11 papers in professional, peer-reviewed journals.

B.   Positions and Honors

Positions and Employment

05/2014 – present       Lecturer, Affairs, Shenzhen University School of Medicine, Shenzhen, China

Organizing International Meetings

Other Experience and Honors

1.    First prize in the Science and Technology Award of the Ministry of Education (China)

2.    Third prize in the Guangdong Science and Technology Award

3.    Second prize in the Shenzhen Science and Technology Award

C.   Contributions to Science (*: corresponding/co-corresponding author)

A full list of my publications (in a total of 11) is enclosed at the end of this document.

1.    Rad regulate the Excitation–Contraction Coupling in Heart

Rad (Ras associated with diabetes) GTPase is a monomeric small G protein that binds to the Cavβ subunit of the L-type Ca2+ channel (LCC) to regulate LCC trafficking and activity. We demonstrated that Rad serves as an important endogenous regulator of cardiac excitation-contraction (EC) coupling and βAR signal transduction. Mechanistically, Rad modulation of ICa characteristics, EC coupling efficiency and responsiveness to βAR stimulation can largely be explained in a parsimonious model of Rad–Cavβ-α1 interaction and of Cavβ being a key effector for βAR signaling.

1)    Wang G, Zhu X, Xie W, Han P, Li K, Sun Z, Wang Y, Chen C, et al. Rad as a novel regulator of excitation-contraction coupling and beta-adrenergic signaling in heart. Circ Res. 2010 Feb 5;106(2):317-27

D.   Research Support

Ongoing Research Support

NSFC (China) general project (81670211)                 01/01/2017 to 12/31/2020

Gang Wang                                                                        ￥570,000 (direct cost)

Effect and molecular mechanisms of HIMF during the development of cardiac hypertrophy

GNSF general project (2014A030313548)                  01/01/2015 to 12/31/2018

Gang Wang                                                                        ￥100,000 (direct cost)

The mechanism of down regulation of KCNE2 induced heart hypertrophy

Completed Research Support

None

E.    Peer-reviewed publications (*: corresponding author)

1. Wang G, Zhu X, Xie W, Han P, Li K, Sun Z, Wang Y, Chen C, et al. Rad as a novel regulator of excitation-contraction coupling and beta-adrenergic signaling in heart.Circ Res. 2010 Feb 5;106(2):317-27.
2. Liu W, Deng J, Wang G(co-first), Zhang C, Luo X, Yan D, Su Q, Liu J..KCNE2 modulates cardiac L-type Ca2+ channel.J Mol Cell Cardiol. 2014 Jul;72:208-218.
3. Xingqun Liang, Gang Wang(co-first), Lizhu Lin, Jennifer Lowe, et al .HCN4 Dynamically Marks the First Heart Field and Conduction System Precursors.Circ Res. Circ Res. 2013;113:399-407.
4. Li-jun YAO, Gang WANG(co-first), KF Ou-Yang, et al.Ca2+ sparks and Ca2+ glows in superior cervical ganglion neurons.Acta Pharmacol Sin.2006 Jul;27(7):848-852
5. Liu WJ , Deng JX, Wang G, Gao KP, Lin ZX, Liu SY, Wang YH, Liu J.Manipulation of KCNE2 expression modulates action potential duration and Ito and IK in rat and mouseventricular myocytes.Am J Physiol Heart Circ Physiol. 2015 Oct;309(8):H1288-302. doi: 10.1152/ajpheart.00757.2014. Epub 2015 Aug 21.
6. Liang X , Zhang Q, Cattaneo P, Zhuang S, Gong X, Spann NJ, Jiang C, Cao X, Zhao X, Zhang X, Bu L, Wang G, Chen HS, Zhuang T, Yan J, Geng P, Luo L,Banerjee I, Chen Y, Glass CK, Zambon AC, Chen J, Sun Y, Evans SM. Transcription factor ISL1 is essential for pacemaker development and function.J Clin Invest. 2015 Aug 3;125(8):3256-68. doi: 10.1172/JCI68257. Epub 2015 Jul 20.
7. Yuanchao Xue, Kunfu Ouyang, Jie Huang, Yu Zhou, Hong Ouyang, Hairi Li, Gang Wang, Qijia Wu,Chaoliang Wei, Yanzhen Bi, Li Jiang, Zhiqiang Cai, Hui Sun, Kang Zhang, Yi Zhang, Ju Chen, Xiang-Dong Fu.Direct Conversion of Fibroblasts to Neurons by Reprogramming PTB-Regulated microRNA Circuits.Cell. 2013 Jan 17; 152(1-2): 82–96.
8. Liang X, Sun Y, Ye M, Scimia MC, Cheng H, Martin J, Wang G, Rearden A, Wu C, Peterson KL, Powell HC, Evans SM, Chen J.Targeted ablation of PINCH1 and PINCH2 from murine myocardium results in dilated cardiomyopathy and early postnatal lethality.Circulation. 2009 Aug 18;120(7):568-76.
9. Efe JA, Hilcove S, Kim J, Zhou H, Ouyang K, Wang G, Chen J, Ding S.Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy.Nat Cell Biol. 2011 Mar;13(3):215-22.
10. Shen T, Aneas I, Sakabe N, Dirschinger RJ, Wang G, Smemo S, Westlund JM, Cheng H, Dalton N, Gu Y, Boogerd CJ, Cai CL, Peterson K, Chen J, Nobrega MA, Evans SM.Tbx20 regulates a genetic program essential to adult mouse cardiomyocyte function.J Clin Invest. 2011 Dec 1;121(12):4640-54.
11. Deng J, Wang G, Huang Q, Yan Y, Li K, Tan W, Jin C, Wang Y, Liu J(*). Oxidative stress-induced leaky sarcoplasmic reticulum underlying acute heart failure in severe burn trauma. Free Radic Biol Med. 2008 Feb 1;44(3):375-85. Epub 2007 Oct 11