BIOGRAPHICAL SKETCH 　 　

NAME: Wang, Zhongyuan 　 　

POSITION TITLE: Lecturer of Pharmocology, Shenzhen University School of Medicine 　 　

EDUCATION/TRAINING   　 　

A.  Personal Statement 　 　

My research focus is in the molecular and cellular mechanisms of cancer, namely the role of the Hippo and Wnt pathways in tumorigenesis, cancer development and metastasis. I am also interested in the development of anti-tumor drugs against the Hippo and Wnt pathways. 　 　 　 　

B.  Positions and Honors 　 　

Positions and Employment 　 　

07/2014 – present Lecturer; Department of Pharmocology, School of Medicine, Shenzhen University, Shenzhen, China   　 　

C.  Research Support 　 　 

Ongoing Research Support 　 　

NSFC (China) (31501143 )                   01/01/20 16  to 12/31/20 18 　 　

Zhongyuan Wang, PI ￥ 21 0,000 (direct cost) 　 　

Study of salinomycin regulating Hippo signaling pathway in breast cancer cells 　 　

D.  Peer-reviewed publications ( ^# co-first author; *corresponding author) 　 　 　 　

1.  Zhongyuan Wang #, Bo Li#, Liang Zhou, Shubin Yu, Zijie Su, Jiaxing Song, Qi Sun,a Ou Sha, Xiaomei Wang, Wenqi Jiang, Karl Willert, Lei Wei, Dennis A. Carson*, Desheng Lu*. Prodigiosin inhibits Wnt/β-catenin signaling and exerts anticancer activity in breast cancer cells. Proceedings of the National Academy of Sciences of the United States of America, 2016, 113(46): 13150-13155. 　 　

2.  Zhongyuan Wang #, Yanping Wu#, Haifeng Wang, Yangqing Zhang, Lin Mei, Xuexun Fang, Xudong Zhang, Fang Zhang, Hongbo Chen, Ying Liu, Yuyang Jiang, Shengnan Sun, Yi Zheng, Na Li, Laiqiang Huang*. Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility. Proceedings of the National Academy of Sciences of the United States of America, 2014, 111(1): E89-98. (Selected as Editors’ Choice of Science Signaling) 　 　

3.  Shubin Yu#, Zhongyuan Wang #, Zijie Su, Jiaxing Song, Liang Zhou, Qi Sun, Shanshan Liu, Shiyue Li, Ying Li, Meina Wang, Guo-Qiang Zhang, Xue Zhang, Zhong-Jian Liu*, Desheng Lu*. Gigantol inhibits Wnt/β-catenin signaling and exhibits anticancer activity in breast cancer cells. BMC Complementary and Alternative Medicine, 2018, 18(1): 59. 　 　

4.  Zhongyuan Wang #, Yanping Wu#, Xiaowei Zeng#, Yaping Ma, Jian Liu, Xiaolong Tang, Yongfeng Gao, Kewei Liu, Jinxie Zhang, Pinghong Ming, Laiqiang Huang*, Lin Mei*. Antitumor efficiency of D-alpha-tocopheryl polyethylene glycol 1000 succinate-b-poly(epsilon-caprolactone-ran-lactide) nanoparticle-based delivery of docetaxel in mice bearing cervical cancer. Journal of Biomedical Nanotechnology, 2014, 10(8): 1509-1519. 　 　

5.  Zhongyuan Wang #, Na Li#, Yanyan Wan, Yanping Wu, Tianyang Mu, Yi Zheng, Laiqiang Huang*, Xuexun Fang*. Ubiquitin-intein and SUMO2-intein fusion systems for enhanced protein production and purification. Protein Expression and Purification, 2012, 82(1): 174-178. (Recommended by “Faculty of 1000”) 　 　

6.  Zhongyuan Wang , Haolong Li, Wei Guan, Haili Ling, Zhiyong Wang, Tianyang Mu, Franklin Shuler, Xuexun Fang*. Human SUMOfusion systems enhance protein expression and solubility. Protein Expression and Purification, 2010, 73(2): 203-208. 　 　

7.  Yanping Wu #, Zhongyuan Wang#, Gan Liu #, Xiaowei Zeng, Xusheng Wang, Yongfeng Gao, Lijuan Jiang, Xiaojun Shi, Wei Tao, Laiqiang Huang*, Lin Mei*. Novel Simvastatin-Loaded Nanoparticles Based on Cholic Acid-Core Star-Shaped PLGA for Breast Cancer Treatment. Journal of Biomedical Nanotechnology, 2015, 11(7): 1247-1260.