BIOGRAPHICAL SKETCH 　 　

NAME:  Qi Sun 　 　

POSITION TITLE : Lecturer, Shenzhen University School of Medicine 　 　

EDUCATION/TRAINING   　 　

A. Fields of research 　 　

My research interests lie in tumor signal transduction pathway,   molecular-targeting cancer therapy, and a ntitumor drug development. 　 　

B. Positions and Honors 　 　

Positions and Employment 　 　

03/2011–08/2015 Research Fellow, Department of Molecular-Targeting Cancer Prevention, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Japan. 　 　

09/2015-present Lecturer, Shenzhen University School of Medicine, China 　 　

Honors 　 　

2007-2010 Japanese government (MEXT) Scholarship. 　 　

2007-2010 Japanese Suntory Foundation of Life Scholarship. 　 　

2 016-2020 Overseas High-Caliber Personnel (level C) 　 　   　

C. Contributions to Science  ( ^#  First author , * Corresponding/Co-corresponding author) 　 　

(1) Qi Sun ^# , Shiyue Li, Junjun Li, Zhongyuan Wang, Bo Li, Shan-Shan Liu, Zijie Su, Jiaxing Song, Desheng Lu*, Homoharringtonine regulates the alternative splicing of Bcl-x and Caspase 9 through a protein phosphatase 1-dependent mechanism. Cancer Science. BMC Complementary & Alternative Medicine. 2018. 　 　 　

(2) Shiyue Li ^#  , Qi Sun ^# , Junjun Li, Zhongyuan Wang, Zijie Su, Jiaxing Song, Ying Li, DeSheng LV*, Ouabain inhibits Wnt/b-catenin signaling and induces cytotoxicity in cancer cells. Sci Sin Vitae, 2018, 48. 　 　 　

(3) Qi Sun ^# , Shingo Yogosawa, Yosuke Iizumi, Toshiyuki Sakai*, Yoshihiro Sowa. The alkaloid emetine sensitizes ovarian carcinoma cells to cisplatin through downregulation of bcl-xL. International Journal of Oncology, 2015, 46(1): 389-394. 　 　

(4) Qi Sun ^# , Akira Hirasawa, Takafumi Hara, Ikuo Kimura, Tetsuya Adachi, Takeo Awaji, Masaji Ishiguro, Takayoshi Suzuki, Naoki Miyata, Gozoh Tsujimoto*, Structure-Activity Relationships of GPR120 Agonists Based on a Docking Simulation, Molecular Pharmacology, 2010, 78(5): 804-810. 　 　   

(5) Qi Sun ^# ,  Lifu Bi, XiuLan Su, Kunio Tsurugi, Kazuhiro Mitsui*. Valproate induces apoptosis by inducing accumulation of neutrallipids which was prevented by disruption of the SIR2 gene in Saccharomyces cerevisiae. Federation of European Biochemical Societies letters. 2007, 581(21): 3991-3995. 　 　

D. Research Support 　 　

Ongoing Research Support 　 　

Shenzhen Basic Research Program (JCYJ20170817094611664) 03/09/20 18  to 03/31/20 20 　 　

Qi Sun, PI ￥ 300 ,000 　 　

Emetine inhibits breast cancer through antagonism of Wnt /beta-cantenin signaling pathway. 　 　

Nature Science Foundation of Guangdong Province (2017A030310329) 01/01/20 17  to 12/31/20 19 　 　

Qi Sun, PI ￥ 1 00,000 　 　

Emetine kills breast cancer stem cells through inhibition of Wnt signaling. 　 　 　 　

Shenzhen Peacock Plan ( 827000186) 03/09/20 16  to 12/31/20 19 　 　

Qi Sun, PI ￥ 2,70 0,000 　 　

Development of cancer stem cell-targeted agents through antagonism of Wnt signaling pathway.