BIOGRAPHICAL SKETCH 　 　

Provide the following information for the Senior/key personnel and other significant contributors.
Follow this format for each person.   DO NOT EXCEED FIVE PAGES. 　 　

NAME: Tan, Binbin 　 　

POSITION TITLE: Lecturer of Pharmacology, School of Basic Medical Sciences, Shenzhen University School of Medicine 　 　

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable. Add/delete rows as necessary.) 　 　

A.  Personal Statement 　 　

I have been conferred a doctoral degree from Shanghai Jiao Tong University in 2014. And then I was appointed to a lectureship in Shenzhen University School of Medicine in Oct. 2014. 　 　

My mainly studies on Metabonomics, Lipidomics, Glycomics, Tumor biomarker, a nd t umor microenvironment and immunotherapy . I have been involved in the National Basic Research Program of China (973 program) during the period of my study for a doctor's degree. I have a lot of experience in “Omics” research on cancer and other complex diseases (e.g. Type 2 diabetes mellitus, Obesity),   and I also excel in statistical analysis and bioinformatics. I have published approximately 20 papers in the peer-reviewed professional journals. I am currently in charge of one NSFC program, two Natural Science Foundation of Guangdong Province program, and one Shenzhen Science and Technology Innovation Commission grant program. 　 　 　

B.  Positions and Honors 　 　

Positions and Employment 　 　

10/2014—present       Lecturer,  Department of Pharmacology ,   Shenzhen University School of Medicine, Shenzhen, China 　 　

Personal Awards and H onors 　 　

1.  Honored with the “Excellent master student” of Central South University, 2008 　 　

2.  Award the scholarship to study abroad granted by China Scholarship Council, 2012—2013 　 　

3.  Award the Doctoral graduate National Scholarship, 2013 　 　

4.  Honored with the “Three Good Student” of Shanghai Jiao Tong University, 2013 　 　

5.  Honored with the “Outstanding graduates” of Shanghai Jiao Tong University ,  2014 　 　

6.  Recognized as Overseas High-Caliber Personnel (Level C) of Shenzhen, 2015 　 　

7.  Recognized as “Leading talent” of Nanshan District, Shenzhen, 2017. 　 　 　 　

C.  Contributions to Science  (*: corresponding/co-corresponding author) 　 　

Publications  (*: corresponding/co-corresponding author): 　 　 　 　

　1. Binbin Tan^#, Di Xiang^#, Meng Jia, Li Fu^*. 2018. The current status and perspective of metabonomics in breast cancer biomarker research (in Chinese). Sci Sin Vitae, 48, doi: 10.1360/N052017-00221.　 　

2.  Li Fu ^#* , Yanru Qin ^# , Xiaoyan Ming ^# , Xianbo Zuo ^# , Yuwen Diao ^# , Liyi Zhang, Jiaoyu Ai, Beilei Liu,Tuxiong Huang, Tingting Cao, Binbin Tan , Di Xiang, Chuimian Zeng, Jing Gong, Qiangfeng Zhang, Suisui Dong, Juan Chen, Haibo Liu, Jianlin Wu, Robert Z. Qi, Dan Xie, Lidong Wang, Xinyuan Guan ^* . 2017. RNA editing of SLC22A3 drives early tumor invasion and metastasis in familial esophageal cancer. Proc Natl Acad Sci U S A , 114  (23): E4631-E4640. 　 　

3.  Tingting Cao, Di Xiang, Beilei Liu, Tuxiong Huang, Binbin Tan , Chuimian Zeng, Zhongyuan Wang, Xiaoyan Ming, Liyi Zhang, Guangyi Jin, Feng Li, Jianlin Wu, Xinyuan Guan, Desheng Lu, Li Fu ^* . 2017. FZD7 is a novel prognostic marker and promotes tumor metastasis via WNT and EMT signaling pathways in esophageal squamous cell carcinoma. Oncotarget , 8 : 65957-65968. 　 　

4.  Tingting Cao ^# , Shuhai Lin ^# , Li Fu ^# , Zhi Tang, Chiming Che, Liyi Zhang, Xiaoyan Ming, Tengfei Liu, Xuming Tang, Binbin Tan , Di Xiang, Feng Li, Onyee Chan, Dan Xie, Zongwei Cai ^* , Xinyuan Guan ^* . 2017. Eukaryotic translation initiation factor 5A2 promotes metabolic reprogramming in hepatocellular carcinoma cells. Carcinogenesis , 38(1): 94-104. 　 　

5.  Xia Zou ^# , Maki Yoshida ^# , Chiaki Nagai-Okatani ^# , Jun Iwaki, Atsushi Matsuda, Binbin Tan , Kozue Hagiwara, Takashi Sato, Yoko Itakura, Erika Noro, Hiroyuki Kaji, Masashi Toyoda, Yan Zhang, Hisashi Narimatsu, Atsushi Kuno ^* . 2017. A standardized method for lectin microarray-based tissue glycome mapping. Scientific Reports , 7 (43560): 1-12. 　 　

6.  Binbin Tan , Atsushi Matsuda, Yan Zhang, Atsushi Kuno, Hisashi Narimatsu ^* . 2014. Multilectin-assisted fractionation for improved single-dot tissue glycome profiling in clinical glycoproteomics, Molecular Biosystems , 10 (2): 201-205. 　 　

7.  Atsushi Kuno, Atsushi Matsuda, Sachiko Unno, Binbin Tan , Jun Hirabayashi; Hisashi Narimatsu ^* . 2014. Differential glycan analysis of an endogenous glycoprotein: toward clinical implementation--from sample pretreatment to data standardization. Methods in Molecular Biology , 1200 : 265-285. 　 　

8.  Binbin Tan , Yunping Qiu, Xia Zou, Tianlu Chen, Guoxiang Xie, Yu Cheng, Taotao Dong, Linjing Zhao, Bo Feng, Xiaofang Hu, Lisa X. Xu, Aihua Zhao, Menghui Zhang, Guoxiang Cai, Sanjun Cai, Zhangxiang Zhou, Minhua Zheng, Yan Zhang ^* , Wei Jia ^* . 2013. Metabonomics identifies serum metabolite markers of colorectal cancer. Journal of Proteome Research,   12 (6): 3000-3009. 　 　

9.  Xia Zou ^# , Bo Feng ^# , Taotao Dong, Guoquan Yan, Binbin Tan , Hao Shen, Ao Huang, Xiu Zhang, Menghui Zhang, Pengyuan Yang, Minhua Zheng, Yan Zhang ^* . 2013. Up-regulation of type I collagen during tumorigenesis of colorectal cancer revealed by quantitative proteomic analysis. Journal of Proteomics , 94 (6): 473-485. 　 　

10.  Liangxiao Zhang ^* , Chunlan Tang, Dongsheng Cao, Yingxu Zeng, Binbin Tan , Maomao Zeng, Wei Fan, Hongbin Xiao ^* , Yizeng Liang ^* . 2013. Strategies for structure elucidation of small molecules using gas chromatography-mass spectrometric data. TrAC Trends in Analytical Chemistry , 47 : 37-46. 　 　

11.  Liangxiao Zhang, Binbin Tan , Maomao Zeng, Hongmei Lu, Yizeng Liang ^* . 2012. Establishment of reliable mass spectra and retention indices library: Identification of fatty acids in human plasma without authentic standards. Talanta , 88 : 311-317. 　 　

12.  Yu Cheng, Guoxiang Xie, Tianlu Chen, Yunping Qiu, Xia Zou, Minhua Zheng, Binbin Tan , Bo Feng, Taotao Dong, Pingang He, Linjing Zhao, Aihua Zhao, Lisa X. Xu, Yan Zhang ^* , Wei Jia ^* . 2012. Distinct urinary metabolic profile of human colorectal cancer. Journal of Proteome Research,   11 (2): 1354-1363. 　 　

13.  Zhimin Zhang, Yizeng Liang ^* , Hongmei Lu, Binbin Tan , Xiaona Xu, Miguel Ferro. 2012. Multiscale peak alignment for chromatographic datasets. Journal of Chromatography A , 1223 : 93-106. 　 　

14.  Hongdong Li, Yizeng Liang ^* , Qingsong Xu, Dongsheng Cao, Binbin Tan , Baichuan Deng, Chenchen Lin. 2011. Recipe for uncovering predictive genes using support vector machines based on model population analysis. IEEE-ACM Transactions on Computational Biology and Bioinformatics , 8 :1633-1641. 　 　

15.  Binbin Tan , Yizeng Liang ^* , Lunzhao Yi, Hongdong Li, Zhiguang Zhou, Xiaoyan Ji, Jiahui Deng. 2010. Identification of free fatty acids profiling of type 2 diabetes mellitus and exploring possible biomarkers by GC-MS coupled with chemometrics. Metabolomics , 6 (2):219-228. 　 　

16.  Liangxiao Zhang, Xiaoyan Ji, Binbin Tan , Yizeng Liang ^* , Nannan Liang, Xiangli Wang, Hui Dai. 2010. Identification of the composition of fatty acids in eucommia ulmoides seed oil by fraction chain length and mass spectrometry. Food Chemistry,   121 (3): 815-819. 　 　

17.  Hongdong Li, Maomao Zeng, Binbin Tan , Yizeng Liang ^* , Qingsong Xu, Dongsheng Cao. 2010. Recipe for revealing informative metabolites based on model population analysis. Metabolomics , 6 (3):353-361.

Conference article s  (*: corresponding/co-corresponding author): 　 　

1.  Tan B., Matsuda A., Kuno A., Zhang Y., Narimatsu H.*. 2013. Improvement of lectin microarray-based tissue glycan profiling with lectin-assisted fractionation for glyco-biomarker discovery, HUPO the 12th Annual World Congress, Yokohama, Japan, 2013.09.11-09.18 　 　

2.  Tan B., Chen T., Zou X., Cheng Y., Dong T., Zhao L., Feng B., Zhao A., Zhang M., Zheng M., Jia W.*, Zhang Y.*. 2012. Identification of serum metabolite markers of colorectal cancer and potential clinical application, AOHUPO the 6th congress, Beijing, P.R. China, 2012.05.05-05.07

D.  Research Support 　 　

Ongoing Research Support 　 　

NSFC (China) ( 81702104)                                  01/01/2018 to 12/31/2020 　 　

Binbin Tan, Project manager                                ￥2 00 , 000  (direct cost) 　 　

Investigation of specific biomarkers for triple negative breast   cancer using integrated metabolomics based on multiple mass   spectrometric united technologies  　 　

Natural Science Foundation of Guangdong Province of China (2016A030313044)     　 　

01/06/ 2016  to 01/06/ 2019 　 　

Binbin Tan, Project manager                                ￥ 100 , 000   　 　

Research on the mechanism of HMGCS2 in lipid metabolism reprogramming in colorectal cancer 　 　

Natural Science Foundation of Guangdong Province of China (2017A030310030)   　 　

01/01/2017 to 12/31/2019 　 　

Binbin Tan, Project manager                                ￥ 100 , 000   　 　

Investigation of the metabolic profiling characteristics and specific biomarkers for triple negative breast   cancer using integrated metabolomics 　 　

Shenzhen Science and Technology Innovation Commission grant 　 　

                                                                              01/03/2018 to 31/03/2020 　 　

Binbin Tan, Project manager                                   ￥ 300 , 000 　 　

Investigation of specific biomarkers for triple negative breast   cancer based on metabolomics platform 　 　

Completed Research Support 　 　

Medical Science Foundation of Guangdong province (A2015178)      01/07/2015 to 30/06/2017 　 　

        Binbin Tan, Project manager                                                                  ￥ 5 , 000 　 　

     Research on early diagnosis of colorectal cancer based on clinical metabonomcis 　 　

Natural Science Foundation of Shenzhen University (201571)            01/06/2015 to 31/05/2017 　 　

        Binbin Tan, Project manager                                                                   ￥ 60 , 000 　 　

       Study on early diagnosis of colorectal cancer based on metabonomcis