NAME: Ying, Ying

POSITION TITLE: Associate Professor

EDUCATION/TRAINING

A.   Personal Statement

I am an Associate Professor in the Department of Physiology, Shenzhen University Health Science Center since 2011. I obtained my M.Sc from University College London in 2003 and my Ph.D from the University of Heidelberg in 2007. I then came to the Chinese University of Hong Kong, where I was a Postdoctal fellow in the Department of Clinical Oncology. My research has contributed fundamentally to current understanding of the molecular mechanisms underlying 1) transcriptional and epigenetic regulation in colorectal cancer development; and 2) the pathogenesis of metabolic and neurodegenerative diseases. Research in my lab has been continuously supported by the National Natural Science Foundation in China (NSFC) and the Shenzhen Basic Research Project. I am currently mentoring three MSc candidates.

B.   Positions and Honors

12 / 2010 – 08 / 2012        Lecturer, Department of Physiology, Shenzhen University Health Science Center, Shenzhen, China

0 9 /20 13 – present         Associate Professor, Department of Physiology, Shenzhen University Health Science Center, Shenzhen, China

      02/2013 – present        Overseas High-Caliber Personnel (Level B)

C.   Contributions to Science (*: corresponding/co-corresponding author ； ^#: first/co-first author)

1. Xing-sheng Shu^*, Yingying Zhao, Yanmei Sun, Lan Zhong, Yingduan Cheng, Yixiang Zhang, Kaile Ning, Qian Tao, Yejun Wang^*, Ying Ying^*. PBRM1 restricts the basal activity of the innate immune system by repressing retinoic acid-inducible gene-I-like receptor signalling and is a potential prognostic biomarker for colon cancer. Journal of Pathology 2018;244(1):36-48.

2. Yixiang Zhang^#, Yeqing Yuan^#, Pei Liang^#, Zhaoxia Zhang, Xiaojing Guo, Ligang Xia, Yingying Zhao, Xing-sheng Shu, Shengkun Sun, Ying Ying^*, Yingduan Cheng^*. Overexpression of a novel candidate oncogene KIF14 correlates with tumor progression and poor prognosis in prostate cancer.  11. Meiqi Zeng, Junfei Niu, Ping Luan, Ying Ying, Ruiping Pang, Qingning Su, Huazhang Zhu, Jingqiang Huang, Huju Chi, Lihong Zhang, Xinmin Fan, Ou Sha. The Change of Nociceptive Neurons in the Rat Trigeminal Ganglia at Different Postnatal Ages. 2017. CNS Neurosci Ther. 23(2):190-193.

   12. Tingxiu Xiang, Yichao Fan, Chunhong Li, Lili Li, Ying Ying, Junhao Mu, Weiyan Peng, Yixiao Feng, Michael Oberst, Kathleen Kelly, Guosheng Ren, Qian Tao. DACT2 silencing by promoter CpG methylation disrupts its regulation of epithelial-to-mesenchymal transition and cytoskeleton reorganization in breast cancer cells. 2016. Oncotarget 7(43): 70924–70935.

   13. Xing-sheng Shu, Hua Geng, Lili Li, Jianming Ying, Chunhong Ma, Yajun Wang, Fan Fong Poon,Xian Wang, Ying Ying, Winnie Yeo, Gopesh Srivastava, Sai Wah Tsao, Jun Yu, Joseph J. Y. Sung, Shi Huang, Anthony T. C. Chan, Qian Tao. The Epigenetic Modifier PRDM5 functions as a tumor suppressor through modulating WNT/b-Catenin signaling and is frequently silenced in multiple tumors. 2011. PLoS One 6(11):e27346.
   14. Tingxiu Xiang, Lili Li, Yichao Fan, Yanyan Jiang, Ying Ying, Thomas C. putti, Qian Tao, and Guosheng Ren. PLCD1 is a functional tumor suppressor inducing G2/M arrest and frequently methylated  in breast cancer. 2010.  Cancer Biology & Therapy 10:5, 520-527.
   15.  Daniel Waterkamp, Oliver J. Müller, Ying Ying, MartinTrepel, Jürgen A. Kleinschmidt. Isolation of targeted AAV2 vectors from novel virusdisplay libraries. Journal of Gene Medicine 2006, 8 (11): 1307-1319.

    

   D.   Research Support

   Ongoing Research Support

   NSFC (China) key project (81670760)                01/01/2017 to 31/12/2020

   Ying Ying, PI                                                                    ￥510,000  (direct cost)

   14-3-3ζ facilitates CDK5 and GSK3β-induced tauhyperphosphorylation: a potential mechanim for degeneration of retinal ganglion cells in early phase of diabetes

    

   Shenzhen Science and Technology Innovation Commission grant (JCYJ20160422091523612)                                                                                                             01/01/2017 to 31/12/2018

   Ying Ying, PI                                                                    ￥300,000

   Study of molecular mechanisms by which Vanadyl bisacetylacetonate protects retinal ganglion cells from neurodegeneration in high-fat diet-induced diabetic retinopathy.

    

   Completed Research Support

   NSFC (China) key project (81200602)                01/01/2013 to 31/12/2015

   Ying Ying, PI                                                                    ￥230,000  (direct cost)

   Protective effects of GLP-1/beta-catenin/TCF signaling pathway on cardiomyocyte apoptosis in diabetic rats and its mechanism study

    

   Distinguished Young Talents in Higher Education of Guangdong (2012LYM_0119)

                                                                                       01/12/2012 to 31/12/2015

   Ying Ying, PI                                                                    ￥30,000

   The role of Syntabulin in cAM-potentiated insulin secretion

    

   Shenzhen Science and Technology Innovation Commission grant (JCYJ20140418091413550)                

   Ying Ying, PI                                                                    ￥250,000  

   The role of AMPK/mTOR-mediated autophagy in early phase of diabetic retinopathy