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Wang, Xiaomei (Professor)

Wang, Xiaomei (Professor) Professor

Basic Medical School

Professor

Department of Physiology

BIOGRAPHICAL SKETCH

NAME: Wang, Xiaomei

POSITION TITLE: Professor of Physiology; Vice Dean for Laboratory & Device Management, Shenzhen University School of Medicine

EDUCATION/TRAINING

INSTITUTION AND LOCATION

DEGREE

 

Completion Date

MM/YYYY

 

FIELD OF STUDY

 

Norman Bethune Medical University, Jilin, China

B. Med

07/1990

Environmental Medicine

Norman Bethune Medical University, Jilin, China

M.Sc.

07/1993

Radioactive Medicine

Jilin University, Jilin, China

Ph.D.

07/2002

Radioactive Medicine

School of Medicine,Shantou University, Shantou, China

Postdoctoral

09/2004

Basic Medicine

University of California, San Diego, CA, USA

 

Visiting Professor

 

02/2017

 

Cancer therapy

 

 

A.   Personal Statement

My research interests are in comprehensive cancer therapy and checking toxicity of functional nano-particles . I served as one of founding professors of the Shenzhen University School of Medicine from 20 06 to 20 09 . My lab is actively exploring how to design multi-target tumor vaccines and measure the associated anti-tumor effects and molecular mechanisms. We have also established a 3D culture system to incubate oocytes during maturation and follicle development in vitro and have used this system to detect the biosafety of Quantum dots.  Research in my lab has been supported by one grant from the National Natural Science Foundation in China (NSFC), one Key International Collaboration grant and four regular grants in Shenzhen since 200 7 . I organized the Annual Symposium on Bio-physics in Guangdong province in 20 09 . I have published > 30 papers in peer-reviewed professional journals. I am currently mentoring three postdoctoral fellows and three M . Sc candidates.

 

B.   Positions and Honors

Positions and Employment

0 8 /199 3 – 08 /199 9        Associate Chief Physician, Center of Disease Prevention and Control, Jilin, China

10 /20 04 – 06/2006     Associate Professor, Professor, College of Life Science, Shenzhen University,Shenzhen, China

0 7 /20 06 –      02/2009     Professor , Department of School of Medicine Preparation , Shenzhen University, Shenzhen , China

03/2009-12/2014         Professor , Director of Experimental Teaching Center, School of Medicine , Shenzhen University, Shenzhen , China

01/201 5 – present      Professor, Vice Dean for Laboratory & Device Management, School of Medicine, Shenzhen University,Shenzhen, China

 

Organizing Meetings

1.    O rganizer, the Guangdong Conference on Biophysics : May 13 -1 6 th, 20 09 , Shenzhen .

2.    Organizer, the Guangdong Conference on Biomagnetics: Jun17-20th, 2010, Shenzhen.

Other Experience and Honors

1.    Editorial Board Member, Carcinogenesis , Teratogenesis & Mutagenesis ( Chinese ): 20 10 -present

2.    Editorial Board Member, Cancer Research on Prevention and Treatment  ( Chinese ): 20 10 -present

  1. Council Member and Board Member, Guangdong Society for Biological Physics, 2009-present
  2. Vice-Director, National Society of Bio-electro-magnetics, China  2010-present
  3. Council Member, Guangdong Experimental Animal Society 2012-present
  4. Council Member, Shenzhen Bioengineering Society 2007-2015
  5. Vice-Director,, Guangdong Experimental Animal Society 2013-present
  6. Third prize for Progress of Science and Technology (3rd author) for "Radioprotective effect of beta carotene", 1999
  7. Third prize for Science and Technology Progress in Jilin province (2nd author) for  "Protection experimental effects of beta carotene on skin damaged by UV”, 2001
  8. Excellence Award for Science and Technology Research, Shantou University, 2005
  9. Talent Cultivation Project , Department of education, Guangdong Province, 2006
  10.  Excellent Teacher Award, College of life science, Shenzhen University, 2008
  11. First National Prize for Excellence in Undergraduate Medical Experimental Design Contest (tutor), 2010
  12. Outstanding Communist Party Member, School of medicine. Excellence in Medical Teaching, Experimental Center, Shenzhen University, 2011
  13. Second National Prize for Excellence in Undergraduate Medical Experimental Design Contest (tutor), 2012
  14. First Class Academic Prize of Natural Science of Shenzhen government (5th author), 2013
  15. Prominent Teacher in the Shenzhen Government (1st author), 2014
  16. Second class academic prize of the Natural Science of Guangdong Province (9th author), 2015

 

C.   Contributions to Science (*: corresponding/co-author)

A full list of my publications (total of 33) is enclosed at the end of this document.

 

1.      Establishment of a 3D culture system to incubate non-antral follicle development and application to monitor quantum dot toxicity.

Functional fluorescent quantum dots can be used for early tumor diagnosis. Our lab monitored the cellular and reproductive toxicity of quantum dots. Toxicity during oocyte development is difficult to measure in vivo. Consequently, our lab set up a culture system to study the toxic effects of quantum dots on oocytes in vitro, using the quantum dots as the labeling probe in vivo and performed single molecule imaging.

 

1)    Xu Gaixia, Lin Suxia, Law Wing-Cheung, Indrajit Roy, Lin Xiaotan, Mei Shujiang, Ma Hanwu, Chen Siping, Niu Hanben, Wang Xiaomei*. The Invasion and Reproductive Toxicity of QDs-Transferrin Bioconjugates on Preantral Follicle in vitro, Theranostics, 2: 734-745, 2012.（IF=7.827）

2)    Lin Guimiao, Ouyang Qingling, Hu Rui, Zhangchi Ding, Jinglin Tian, Feng Yin, Xu Gaixia,  Chen Qiang, Wang Xiaomei*, Yong Ken-Tye*. In vivo toxicity assessment of non-cadmium quantum dots in BALB/c mice. Nanomedicine: Nanotechnology, Biology, and Medicine, 11:341-350, 2015.（IF=5.978）

3)    Wang Xiaomei#, Tian Jinglin,# Yong Ken-Tye,  Zhu Xuedan ,Lin Marie Chia-Mi, Jiang Wenxiao, Li Jiefeng, Huang Qijun and Guimiao Lin. Immunotoxicity assessment of CdSe/ZnS quantum dots in macrophages, lymphocytes and BALB/c mice. J Nanobiotechnology. 2016; 14: 10. (IF=4.239).

4)    Gaixia Xu#, Guimiao Lin#, Suxia Lin, Na Wu, Yueyue Deng, Gang Feng, Qiang Chen, Junle Qu, Danni Chen, Siping Chen, Hanben Niu, Shujiang Mei*, Ken-Tye Yong* and Xiaomei Wang*. The Reproductive Toxicity of CdSe/ZnS Quantum Dots on the in vivo Ovarian Function and in vitro Fertilization. Scientific Reports, 2016. 6：37677~37677.（IF=5.078）

 

2.      Tumor therapy vaccine research and development

We have performed research and development of tumor "cocktail" therapy. We found that irradiation or chemical drug exposure induces the early response gene 1 (Egr-1) and promotes target gene expression (such as the tumor suppressor gene Xpo4, Endostatin and telomerase reverse transcriptase fragment (hTERTC27)) to inhibit tumor growth. We have also used the Toll-like Receptor and its utility as a tumor multi-biomarker to develop a vaccine and apply it to treat the patients in clinic.

 

1)    Lin Guimiao, Lin Marie Chia-Mi, Lin Suxia, Yao Hong, Yu Shuihong, Yi Wanxian, Xu Gaixia, Ng Samuel Sai-Ming, Chen Siping, Yu Jing, Wang Xiaomei* and Yang Baoxue*. Early Growth Response Protein-1 Promoter-Mediated Synergistic Anti-tumor Effect of hTERTC27 Gene Therapy and 5-FU on Nasopharyngeal Carcinoma. Cancer Biother Radio, 27: 434-441, 2012.（IF=1.738）

2)    Lin Guimiao, Chen Qiang, Yu Shuihong, Lin Suxia, Ding Zhangchi, Yao Hong, Chen Siping, Lin Marie Chia-Mi*, and Wang Xiaomei*. Over-expression of hTERT C-terminal polypeptide sensitizes HeLa cells to 5-Fluorouracil induced growth inhibition and apoptosis. Mol Med Rep. 9:279-284, 2014.（IF=1.484）

3)    Lin Guimiao#, Wang Xiaomei#*, Yi Wanxian, Zhang Chuaxia, Xu Gaixia, Zhu Xiaomei, Cai Zhiming, Liu Yu, Diao Yuwen, Lin Marie C, Jin Guangyi(*), A conjugate of octamer-binding transcription factor 4 and toll-like receptor 7 agonist prevents the growth and metastasis of testis embryonic carcinoma., J Transl Med, 2015.5.20, 13（166）

4)    Lin Guimiao, Chen Chih-Kuang*, Yin Feng,Yang Chenbin, Tian Jinlin, Chen Ting, Xu Gaixia, He Chunxiao, Li Marie Chia-Min, Wang Jie, Lu Fei*,Wang Xiaomei*,and Yong Ken-Tye*.Biodegradable Nanoparticles as siRNA Carriers for in vivo Gene Silencing and Pancreatic Cancer Therapy. 2017.5 32327--3337. (IF=4.726)

 

3.      Biomagnetics effects on nerve regeneration and bone consenescence.

In 1985, our lab in Shenzhen University studied biomagnetic effects and the preventative effects of a magnetic field on osteoporosis. In 2016, we reported the promoting effects of a magnetic field on nerve recovery and have confirmed its protective role in bone senescence.

1)    Qiang Chen, Guimiao Lin, NanWu, Sheng-wei Tang, Zhijia Zheng, Marie Chia-mi Lin, Gai-xia Xu, Hao Liu, Yueyue Deng, Xiaoyun Zhang, Si-ping Chen, Xiaomei Wang* and Han-ben Niu*. Early Exposure of Rotating Magnetic Fields Promotes Central Nervous Regeneration in Planarian Girardia sinensis. Bioelectromagnetics. 2016, 37(4)：244-255.（IF=1.583）

 

4.      Development of the novel trace analysis for contaminants

We have also analyzed  trace contaminants in food, such as  Clindamycin, Aflatoxin M1 and Pirlimycin residues in milk using Biotin-Streptavidin-Amplified Enzyme-Linked Immunosorbent Assay.

1)    Wang Xiaomei, Luo, Pengjie, Chen, Jinlian , Huang, Yuting, Jiang, Wenxiao. Development of a quantitative immuno-affinity test column assay for on-site screening of clindamycin residues in milk. International Dairy Journal.2016, 55:59-63.( IF=1.938).

2)    Jiang Wenxiao, Beier RC, Luo P, Zhai P, Wu Nan, Lin Guimiao, Wang Xiaomei*, Xu Gaixia. Analysis of Pirlimycin Residues in Beef Muscle, Milk, and Honey by a Biotin-Streptavidin-Amplified Enzyme-Linked Immunosorbent Assay. J Agric Food Chem. 2016 Jan 13;61(1):364-70.（IF=2.912）

3)    Jiang, Wenxiao(#), Beloglazova, Natalia V, Luo,Pengjie, Guo,Ping, Lin, Guimiao, Wang, Xiaomei*. A Dual-Color Quantum Dots Encoded Frit-Based Immunoassay for Visual Detection of Aflatoxin M1 and Pirlimycin Residues in Milk. J Agric Food Chem. 2017.3.1, 65（8）：1822~1828. (IF=2.912)

 

 

D.   Research Support

Ongoing Research Support

National key research and development plan (2016YFC0904601)

07/01/2016 to 12/31/2018

Xiaomei Wang, PI                                                              ￥720,000

 

Shenzhen disciplinary layout research project (NO.20160084)             

06/01/2017 to 05/31/2020

Xiaomei Wang, PI                                                              ￥3,000,000

Mechanism of DNA damage repair and tumor individual therapy

 

International collaboration grant (Shenzhen) （GJHZ20170313111237888）

07/01/2017 to 06/31/2020

Xiaomei Wang, PI                                                              ￥500,000

Research and development for FZD7-SSEA3 antitumor vaccine

 

NSFC (China) key project (81772002)                01/01/2018 to 12/31/2021

Xiaomei Wang, PI                                                              ￥550,000 (direct cost)

The Rehabilitation Effects of Rotating Magnetic Field Exposure on Bone Aging Diseases and its Mechanism

 

 

Shenzhen Science and Technology Innovation Commission grant (201700)                                        

04/01/2018 to 03/31/2021

Xiaomei Wang, PI                                                              ￥3,000,000

Design conjugated vaccines of polypeptide and polysaccharose and their antitumor effects

 

 

 

 

Completed Research Support

 

Guangdong Province Natural Science project     01/01/2004 to 12/31/2006

Xiaomei Wang, PI                                                                      ￥50,000

Relationship between expression of Dynein and oocyte aneuploidy

Shenzhen-Hong Kong Innovation Circle project       09/01/2008 to 08/31/2010

Xiaomei Wang, PI                                                                      ￥150,000

exploratory study on gene radiation treatment of nasopharyngeal carcinoma drug

 

Guangdong Province Natural Science project     01/01/2011 to 12/31/2013

Xiaomei Wang, PI                                                                      ￥50,000

chemical drug induced antiangiogenic gene targeted drug development and evaluation

 

Shenzhen Basic Research Project:                    01/01/2012 to 12/31/2014

Xiaomei Wang, PI                                                                      ￥100,000

the common molecular mechanism of magnetic biological effects

 

Collaborating research: the key project of National Natural Science Fund 01/01/2013 to 12/31/2017

Xiaomei Wang, PI                                                                      ￥340,000

optical imaging method of single cells with nanometer resolution research

 

Shenzhen Innovation Science and Technology Project   05/01/2013 to 04/31/2015

Xiaomei Wang, PI                                                                              ￥100,000

The anti-tumor  effect of immunological modified vaccine united with radiation induced gene drug

Shenzhen Innovation Science and Technology Project   01/01/2015 to 12/31/2016

Xiaomei Wang, PI                                                                                ￥300,000

The killing effect of immunological modified OCT4 and SSEA-3 conjugated vaccine on testicular cancer and its mechanism

 

 

 

Peer-reviewed publications (*: corresponding author)

 

1.      Jiang, Wenxiao(#), Beloglazova, Natalia V, Luo,Pengjie, Guo,Ping, Lin, Guimiao, Wang, Xiaomei*. A Dual-Color Quantum Dots Encoded Frit-Based Immunoassay for Visual Detection of Aflatoxin M1 and Pirlimycin Residues in Milk. J Agric Food Chem. 2017.3.1, 65（8）：1822~1828. (IF=2.912)

2.      Chi-Ho Ng#, Nanxi Rao, Wing-Cheung Law*, Gaixia Xu, Tai-Lok Cheung, Fai Tsun Cheng, Xiaomei Wang*, Hau-Chung Man. Enhancing the cell proliferation performance of NiTi substrate by laser diffusion nitriding. Surface and Coatings Technology. 2017.1.15，309：59~66. (IF=2.589)

3.      Lin Guimiao, Chen Chih-Kuang*, Yin Feng,Yang Chenbin, Tian Jinlin, Chen Ting, Xu Gaixia, He Chunxiao, Li Marie Chia-Min, Wang Jie, Lu Fei*,Wang Xiaomei*,and Yong Ken-Tye*.Biodegradable Nanoparticles as siRNA Carriers for in vivo Gene Silencing and Pancreatic Cancer Therapy. 2017.5 32327--3337. (IF=4.726)

4.      Wang Xiaomei, Luo, Pengjie, Chen, Jinlian , Huang, Yuting, Jiang, Wenxiao. Development of a quantitative immuno-affinity test column assay for on-site screening of clindamycin residues in milk. International Dairy Journal.2016, 55:59-63.( IF=1.938).

5.      Wang, Xiaomei, Liufu, Tongling, Beloglazova, Natalia V., Luo, Pengjie, Qu, Jianwen, Jiang, Wenxiao.Development of a Competitive Indirect Enzyme-Linked Immuno- sorbent Assay for Screening Phenylethanolamine A Residues in Pork Samples，Food Analytical Methods, 2016, 11: 3099 - 3106. ( IF=2.16).

6.      Wang Xiaomei#, Tian Jinglin,# Yong Ken-Tye,  Zhu Xuedan ,Lin Marie Chia-Mi, Jiang Wenxiao, Li Jiefeng, Huang Qijun and Guimiao Lin. Immunotoxicity assessment of CdSe/ZnS quantum dots in macrophages, lymphocytes and BALB/c mice. J Nanobiotechnology. 2016; 14: 10. (IF=4.239).

7.      Gaixia Xu#, Guimiao Lin#, Suxia Lin, Na Wu, Yueyue Deng, Gang Feng, Qiang Chen, Junle Qu, Danni Chen, Siping Chen, Hanben Niu, Shujiang Mei*, Ken-Tye Yong* and Xiaomei Wang*. The Reproductive Toxicity of CdSe/ZnS Quantum Dots on the in vivo Ovarian Function and in vitro Fertilization. Scientific Reports, 2016. 6：37677~37677.（IF=5.078）.

8.      Qiang Chen, Guimiao Lin, NanWu, Sheng-wei Tang, Zhijia Zheng, Marie Chia-mi Lin, Gai-xia Xu, Hao Liu, Yueyue Deng, Xiaoyun Zhang, Si-ping Chen, Xiaomei Wang* and Han-ben Niu*. Early Exposure of Rotating Magnetic Fields Promotes Central Nervous Regeneration in Planarian Girardia sinensis. Bioelectromagnetics. 2016, 37(4)：244-255.（IF=1.583）.

9.      Jiang Wenxiao, Beier RC, Luo P, Zhai P, Wu Nan, Lin Guimiao, Wang Xiaomei*, Xu Gaixia. Analysis of Pirlimycin Residues in Beef Muscle, Milk, and Honey by a Biotin-Streptavidin-Amplified Enzyme-Linked Immunosorbent Assay. J Agric Food Chem. 2016 Jan 13;61(1):364-70.（IF=2.912）.

10.   Lin Guimiao#, Wang Xiaomei#*, Yi Wanxian, Zhang Chuaxia, Xu Gaixia, Zhu Xiaomei, Cai Zhiming, Liu Yu, Diao Yuwen, Lin Marie C, Jin Guangyi(*), A conjugate of octamer-binding transcription factor 4 and toll-like receptor 7 agonist prevents the growth and metastasis of testis embryonic carcinoma., J Transl Med, 2015.5.20, 13（166）.

11.   Lin Guimiao, Ouyang Qingling, Hu Rui, Zhangchi Ding, Jinglin Tian, Feng Yin, Xu Gaixia,  Chen Qiang, Wang Xiaomei*, Yong Ken-Tye*. In vivo toxicity assessment of non-cadmium quantum dots in BALB/c mice. Nanomedicine: Nanotechnology, Biology, and Medicine, 11:341-350, 2015.（IF=5.978）

12.   Lin Guimiao, Chen Qiang, Yu Shuihong, Lin Suxia, Ding Zhangchi, Yao Hong, Chen Siping, Lin Marie Chia-Mi*, and Wang Xiaomei*. Over-expression of hTERT C-terminal polypeptide sensitizes HeLa cells to 5-Fluorouracil induced growth inhibition and apoptosis. Mol Med Rep. 9:279-284, 2014.（IF=1.484）

13.   Lin Guimiao, Lin Marie Chia-Mi, Lin Suxia, Yao Hong, Yu Shuihong, Yi Wanxian, Xu Gaixia, Ng Samuel Sai-Ming, Chen Siping, Yu Jing, Wang Xiaomei* and Yang Baoxue*. Early Growth Response Protein-1 Promoter-Mediated Synergistic Anti-tumor Effect of hTERTC27 Gene Therapy and 5-FU on Nasopharyngeal Carcinoma. Cancer Biother Radio, 27: 434-441, 2012.（IF=1.738）

14.   Xu Gaixia, Lin Suxia, Law Wing-Cheung, Indrajit Roy, Lin Xiaotan, Mei Shujiang, Ma Hanwu, Chen Siping, Niu Hanben, Wang Xiaomei*. The Invasion and Reproductive Toxicity of QDs-Transferrin Bioconjugates on Preantral Follicle in vitro, Theranostics, 2: 734-745, 2012.（IF=7.827）

15.   Zhou J , Li Z , Ying M , Liu M , Wang X , Wang X , Cao L , Zhang H , Xu G . Black phosphorus nanosheets for rapid microRNA detection. Nanoscale. 2018 Mar 15;10(11):5060-5064. doi: 10.1039/c7nr08900g.

16.   Dong C, Yang R, Li H, Ke K, Luo C, Yang F, Shi XN, Zhu Y, Liu X, Wong MH, Lin G, Wang X, Leung KS, Kung HF, Chen C, Lin MC Econazole nitrate inhibits PI3K activity and promotes apoptosis in lung cancer cells. Sci Rep. 2017 Dec 21;7(1):17987. doi: 10.1038/s41598-017-18178-0.

17.   Wu N, Zhang Z, Zhou J, Sun Z, Deng Y, Lin G, Ying M, Wang X, Yong KT, Wu C, Xu G.The biocompatibility studies of polymer dots on pregnant mice and fetuses. Nanotheranostics. 2017 Jun 9;1(3):261-271. doi: 10.7150/ntno.18964.

18.   Guimiao Lin, Ting Chen, Jinyun Zou, Yucheng Wang, Xiaomei Wang, Jiefeng Li, Qijun Huang, Zicai Fu, Yingying Zhao, Marie Chia-Mi Lin, Gaixia Xu* and Ken-Tye Yong*. Quantum Dots-siRNA Nanoplexes for Gene Silencing in Central Nervous System Tumor Cells. ORIGINAL RESEARCH published: 04 April 2017 doi: 10.3389/fphar.2017.00182. (IF=3.802)

19.   Zhongyuan Wang, Bo Li, Liang Zhou, Shubin Yu, Zijie Su, Jiaxing Song, Qi Sun, Ou Sha, Xiaomei Wang, Wenqi Jiang, Karl Willert, Lei Wei, Dennis A. Carson, and Desheng Lu. Prodigiosin inhibits Wnt/β-catenin signaling and exerts anticancer activity in breast cancer cells. PNAS, 2016, 113(46):13150-13155.(IF=9.423).

20.   Shen Z, Yao C, Wang Z, Yue L, Fang Z, Yao H, Lin F, Zhao H, Sun YJ, Bian XW, Jiang W, Wang X, Li Y, Lu G, Poon WS, Kung HF, Lin MC. Vastatin, an Endogenous Antiangiogenesis Polypeptide That Is Lost in Hepatocellular Carcinoma, Effectively Inhibits Tumor Metastasis. Mol Ther. 2016 Aug;24(8):1358-68. (IF=6.938)

21.   Lin Guimiao, Wang Xiaomei, Yin Feng, Yong Ken- Tye*. Passive tumor targeting and imaging by using mercaptosuccinic acid-coated near-infrared quantum dots. International Journal of Nanomedicine, 10: 335–345, 2015.（ IF=4.195）

22.   Yu F, Xie D, Ng SS, Lum CT, Cai MY, Cheung WK, Kung HF, Lin G, Wang X, Lin MC. IFITM1 promotes the metastasis of human colorectal cancer via CAV-1.Cancer Lett. 2015 Nov 1;368(1):135-43. doi: 10.1016/j.canlet.2015.07.034.

23.   Lin Guimiao, Ding Zhangchi,Hu Rui, Wang Xiaomei, Chen Qiang, Zhu Xiaomei,Liu Kan,Liang Jinghua,Lu Fangqi,Lei Delin, Xu Gaixia＊and Yong Ken-Tye＊. Cytotoxicity and immune response of CdSe/ZnS Quantum dots towards a murine macrophage cell line.RSC Advances, 4: 5792–5797, 2014.（IF=3.708）

24.   Lin Guimiao, Hu Rui, Law Wing-Cheung, Chen Chih-Kuang, Wang Yucheng, Chin Hui Li, Nguyen Quoc Toan, Lai Cheng Kee, Yoon Ho Sup, Wang Xiaomei, Xu Gaixia, Ye Ling, Cheng Chong and Yong Ken-Tye*. Biodegradable Nanocapsules as siRNA Carriers for Mutant K-Ras Gene Silencing of Human Pancreatic Carcinoma Cells. Small, 9: 2757-2763, 2013.（IF=8.35）

25.   Chen Danni, Xu Gaixia, Bahi Ahmed Ali, Yong Ken- Tye, Zhou Cuihong, Wang Xiaomei, Junle Qu, Paras N. Prasad and Niu Hanben. Uptake of transferring-conjugated quantum dots in single living cells. Chines Optics Letters, 8: 940-943, 2010.（ IF=1.073）

26.   Ali Ahmed Bahi, Halem HH, Wang Xiaomei, Zhang XY. Effect of bacillus thuringiensis var.israelensis endotoxin on the intermediate snail host of schistosoma japonicum. Current Research in Bacteriology, 3: 37-41, 2010.

27.   Ali Ahmed Bahi, WangXiaomei*, Xu Gaixia,Zhao XF, Lin Xiaotan, Zhang XY, Niu Hanben. Quantum dots biodistribution in tissue organs of Healthy male and female mice. Journal of Pharmacology and Toxicology, 4: 229-235, 2009.

28.   Ali Ahmed Bahi, HalemHH, Wang Xiaomei, Huang TH, Zhang XY. Detection of hepatitis B polymerase gene in early embryonic cells from Golden Hamster oocyte and human spermatozoa. International Journal of Virology. 5: 164-169, 2009.

29.   Yao Hong, Samuel S, Wesley O. Tucker, Yuk-Kai-Tiu Tsang, Kwan Manc, Wang Xiaomei, Billy K.C. Chowe, Hsiang-Fu Kung, Tang GP, Lin MC. The Gene Transfection Efficiency of A Folate-PEI600-Cyclodextrin Nanopolymer. Biomaterials, 30: 5793-5803, 2009.（ IF=7.882）

30.   Hu Rui, Yang Chengbin, Wang Yucheng, Lin Guimiao, Qin Wei, Ouyang Qingling, Law Wing-Cheung, Nguyen Quoc Toan,  Yoon Ho Sup, Wang Xiaomei, Yong Ken-Tye, Tang Ben Zhong. Aggregation-induced emission (AIE) dye loaded polymer nanoparticles for gene silencing in pancreatic cancer and their in vitro and in vivo biocompatibility evaluation. Nano Research, 6:1-14, 2014.（ IF=6.963）

31.   Yang XF, Liu JJ, He HW, Zhou L, Gong CM, Wang XM, Yang LQ, Yuan JH, Huang HY, He LH, Zhang B, Zhuang ZX. SiO2 nano-particles induce cytotoxicity and protein expression alteration in HaCaT cells. Particle and fibre Toxicology. 2010, 7(1):854-866.(IF：7.283)

32.   Salem, Halima Hassan#，Ali, Bahy Ahmed*，Huang, Tian-Hua，Qin, Da-Nian，Wang, Xiao-Mei，Xie, Qing-Dong. Use of random amplified polymorphic DNA analysis for economically important food crops，Journal of Integrative Plant Biology，2007，49(12): 1670-1680.

33.   Guizhi Ju#*, Xiaomei Wang, Shibo Fu, Shuzheng Liu. Effect of Ionizing Radiation on the Expression of p16, CyclinD1 and CDK4 in Mouse Thymocytes and Splenocytes. Biomed. Environ.Sci, 2003, 16(1): 47~52.

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