NAME: Lin, Guimiao

POSITION TITLE: Associate Professor; Deputy Director of the Medical Teaching Experimental Center& Director of the Laboratory Animal Center, Shenzhen University School of Medicine

EDUCATION/TRAINING

INSTITUTION AND LOCATION	DEGREE	Completion Date MM/YYYY	FIELD OF STUDY
Jilin University, Jilin, China	B. Med	07/2003	Preventive Medicine
Jilin University, Jilin, China	M.Sc.	07/2006	Pharmacology
Jilin University, Jilin, China	M.D.	07/2012	Pathology and Pathophysiology

 

A.     Personal Statement

My long-standing research interests fall in the biological application and toxicity study of artificial nanomaterials. I have achieved fruitful scientific research results in tumor immunotherapy, gene delivery, nanotoxicology and other fields. I have published 40 SCI articles in international journals such as Small, Nanomedicine: Nanotechnology, Biology, and Medicine, and Theranostics, with a total impact factor of 163 and 504 citations. I have obtained seven grants from the National Natural Science Foundation of China (NSFC), 12 grants from the province or city, and was identified as a Shenzhen Overseas High-level Talent, Nanshan District Leading Talent.

 

B.     Positions and Honors

Positions and Employment

07/ 2006 –– 07/2011   Research Assistant, Shenzhen Graduate School, Peking University, Beijing, China

10 /2011 – 1 0 /201 2         Research Assistant, Nanyang Technological University, Singapore

1 1/201 2 – 12 /201 5         Lecturer, Shenzhen University School of Medicine, Shenzhen, China

12 /20 15 –presen t       Associate Professor, Shenzhen University School of Medicine, Shenzhen, China

 

 

Other Experience and Honors

1. 2017. Pilot talent, C lass C

2. 2015. Overseas high-level talents, C lass C

 

C.     Contributions to Science (*: corresponding/co-corresponding author)

I have engaged in the biological application and toxicity study of artificial nanomaterials such as quantum dot, and obtained a series of original achievements. My research includes: (1) tumor imaging studies of artificial nanomaterials such as quantum dots, succeeding in passive and active tumor-targeting imaging in vivo; (2) developing CPLA and other degradable nanocarriers, achieving siRNA delivery into tumors with high transfection efficiency and good biological compatibility; (3) performing in-depth study on the organ toxicity of cadmium-containing quantum dots, revealing the potential toxicity of CdSe quantum dots on the immune system and reproductive system, proving that the CdSe quantum dots can induce immune system dysfunction and interfere with the normal oocytes maturation and fertilization ability; (4) in vivo toxicological study of non-cadmium quantum dot InP/ZnS, extending the in vivo toxicity of quantum dots from cadmium-containing quantum dots to cadmium-free quantum dots.

 

D.     Research Support

Ongoing Research Support

 

1.NSFC (China) project (21677102)               01/01/2017 to 12/31/2020

Guimiao Lin, PI  ￥620,000 (direct cost)

InP quantum dots: metabolism in liver and kidney and toxicity study

 

2.Shenzhen Science and Technology Innovation Commission grant (JCYJ20170817093725277)                  

                                                                        01/01/2018 to 03/31/2020

Guimiao Lin, PI    ￥400,000

Effect of InP/ ZnS quantum dots on liver microsomal enzymes and its mechanism

 

 

3. Natural Science Foundation of SZU (NO.827-000100, Starting project of Shenzhen high-level overseas talents)

01/01/2016 to 12/31/2018 

Guimiao Lin, PI      ￥2,700,000

Development of DC vaccine loaded with tumor stem cell antigen and its antitumor mechanism

 

 

Completed Research Support

1. NSFC (China) project (81301318)              01/01/2014 to 12/31/2016

Guimiao Lin, PI            ￥230,000

Study on targeted therapy of pancreatic cancer using RNAi technology based on novel and degradable nano-carriers

 

2. Shenzhen Science and Technology Innovation Commission grant (JCYJ20140418182819164)    

12/01/2014 to 12/31/2016

Guimiao Lin, PI                               ￥300,000

Immunotox icity study on CdSe / ZnS quantum dots and their mechanism

 

3. Shenzhen university Starting project (80100035901)             09/01/2012 to 09/30/2015

Guimiao Lin, PI                                   ￥60,000

Novel bio degradable nanoparticles delivering IL - 8 s iRNA for pancreatic cancer gene therapy

 

 

E. Peer-reviewed publications (*: corresponding author)

1.        Lin Guimiao, Chen Chih-Kuang *, Yin Feng, Yang Chengbin, Tian Jinlin, Chen Ting, Xu Gaixia, He Chunxiao, Li Marie Chia‑Min, Wang Jie, Lu Fei *, Wang Xiaomei *and Yong Ken-Tye* .Biodegradable Nanoparticles as siRNA Carriers for in vivo Gene Silencing and Pancreatic Cancer Therapy. J. Mater. Chem. B. 5(18): 3327-3337, 2017    1/1

2.        Lin Guimiao, Chen Ting, Zou Jinyun, Wang Yucheng2, Wang Xiaomei, Li Jiefeng, Huang Qijun, Fu Zicai, Zhao Yingying, Lin Chia‑Mi Marie, Xu Gaixia* and Yong Ken-Tye*.Quantum Dots-siRNA Nanoplexes for Gene Silencing in Central Nervous System Tumor Cells. Frontiers in pharmacology. 8:182, 2017.  1/1

3.        Wang Xiaomei＃, Tian Jinglin＃, Yong Ken-Tye*, Zhu Xuedan, Lin Marie Chia-Mi, Jiang Wenxiao, Li Jiefeng, Huang Qijun, Lin Guimiao*. Immunotoxicity assessment of CdSe/ZnS quantum dots in macrophages, lymphocytes and BALB/c mice. J nanobiotech. 14(1):10, 2016.   7/11

4.        Xu Gaixia＃, Lin Guimiao^＃, Lin Suxia, Wu Nan, Deng Yueyue, Feng Gang, Chen Qiang, Qu Junle, Chen Danni, Chen Siping, Niu Hanben, Mei Shujiang,  Yong Ken-Tye*, WangXiaomei*.The Reproductive  Toxicity  of  CdSe/ZnS  Quantum Dots  on the in vivo Ovarian Function and in vitro Fertilization. Sci Rep. 6:37677, 2016.  2/2

5.        Liu Liwei＃, Lin Guimiao^＃*, Yin Feng, Law Wing-Cheung, Yong Ken-Tye*. Near-infrared fluorescent peptide probes for imaging of tumor in vivo and their biotoxicity evaluation, J Biomed Mater Res A. 104(4):910-916, 2016.  4/4

6.        Chen Qiang＃,Lin Gui-miao^＃, Wu Nan^＃,Tang Sheng-wei,Zheng Zhi-jia , Lin Marie Chia-mi, Xu Gai-xia, Liu Hao, Deng Yue-yue,Zhang Xiao-yun,Chen Si-ping, Wang Xiao-mei*,  and Niu Han-ben. Early Exposure of Rotating Magnetic Fields Promotes Central Nervous Regenerationin Planarian Girardia sinensis. Bioelectromagnetics. 37:244-255, 2016.  0

7.        Lin Guimiao＃, Ouyang Qingling＃, Hu Rui, Zhangchi Ding, Jinglin Tian, Feng Yin, Xu Gaixia,  Chen Qiang, Wang Xiaomei＊, Yong Ken-Tye＊. In vivo toxicity assessment of non-cadmium quantum dots in BALB/c mice. Nanomedicine-Nanotechnology, Biology, and Medicine.11:341-350, 2015.  12/14

8.        Lin Guimiao, Wang Xiaomei, Yin Feng, Yong Ken- Tye＊. Passive tumor targeting and imaging by using mercaptosuccinic acid-coated near-infrared quantum dots. International Journal of Nanomedicine. 10: 335–345, 2015.  10/12

9.        Lin Guimiao, Wang Xiaomei＊, Yi Wanxian , Zhang Chuanxia , Xu Gaixia , Zhu Xiaomei, Cai Zhiming ,  Liu Yu,  Diao Yuwen,  Lin Marie Chia-Mi, Jin Guanyi＊. A conjugate of octamer-binding transcription factor 4 and toll-like receptor 7 agonist prevents the growth and metastasis of testis embryonic carcinoma. Journal of translational medicine. 13(1):166, 2015.  2/3

10.    Danny Jian Hang Tng＃,Song Peiyi＃, Lin Guimiao＃*, Alana Mauluidy Soehartono,Yang Guang,Yang Chengbin,Yin Feng,Tan Cher Heng, Yong Ken-Tye*. Synthesis and characterization of multifunctional hybrid-polymeric nanoparticles for drug delivery and multimodal imaging of cancer. International Journal of Nanomedicine. 10:5771-5786, 2015.   2/2

11.    Lin Guimiao, Yin Feng, Yong Ken- Tye＊. The future of quantum dots in drug discovery. Expert opinion on drug discovery. 9: 991-994, 2014.  4/6

12.    Lin Guimiao＃, Yang Chengbin＃, Hu Rui, Chen Chih-kuang, Law Wing-Cheung, Anderson Tommy, Zhang Butian, Nguyen Quoc Toan, Toh HuiTing, Yoon Ho Sup, Cheng Chong and Yong Ken-Tye＊. Interleukin-8 gene silencing on pancreatic cancer cells using biodegradable polymer nanoplexes. Biomater Sci-Uk . 2: 1007-1015, 2014.  6/10

13.    Lin Guimiao＃，Ding Zhangchi＃，Hu Rui, Wang Xiaomei, Chen Qiang，Zhu Xiaomei，Liu Kan，Liang Jinghua，Lu Fangqi，Lei Delin, Xu Gaixia＊and Yong Ken-Tye＊. Cytotoxicity and immune response of CdSe/ZnS Quantum dots towards a murine macrophage cell line. RSC Advances. 4: 5792–5797, 2014. 3/4

14.    Lin Guimiao＃, Chen Qiang＃, Yu Shuihong, Lin Suxia, Ding Zhangchi, Yao Hong, Chen Siping, Lin Marie Chia-Mi*, and Wang Xiaomei*. Overexpression of hTERT C-terminal polypeptide sensitizes HeLa cells to 5-Fluorouracil induced growth inhibition and apoptosis. Mol Med Rep. 9:279-284, 2014.  3/4

15.    Lin Guimiao, Hu Rui, Law Wing-Cheung, Chen Chih-Kuang, Wang Yucheng, Chin Hui Li, Nguyen Quoc Toan, Lai Cheng Kee, Yoon Ho Sup, Wang Xiaomei, Xu Gaixia, Ye Ling, Cheng Chong and Yong Ken-Tye*. Biodegradable Nanocapsules as siRNA Carriers for Mutant K-Ras Gene Silencing of Human Pancreatic Carcinoma Cells. Small. 9: 2757-2763, 2013.  9/19

16.    Lin Guimiao, Lin Marie Chia-Mi, Lin Suxia, Yao Hong, Yu Shuihong, Yi Wanxian, Xu Gaixia, Ng Samuel Sai-Ming, Chen Siping, Yu Jing, Wang Xiaomei* and Yang Baoxue*. Early Growth Response Protein-1 Promoter-Mediated Synergistic Anti-tumor Effect of hTERTC27 Gene Therapy and 5-FU on Nasopharyngeal Carcinoma. Cancer Biother Radio. 27: 434-441, 2012 . 1/2

17.    Lin Guimiao, Zhao Lijuan, Yin Feng, Lan Rongfeng, Li Lianbo, Zhang Xiaoming, Zhang Hui and Yang Baoxue*. TCF3 Inhibits F9 Embryonal Carcinoma Growth by the Down-regulating of Oct4. Onco Rep. 26:893-899, 2011. 3/7

18.    Yang Chengbin, Chan Kok Ken, Lin Wen-Jen, Soehartono Alana Mauluidy, Lin Guimiao, Toh Huiting,Ho Yoon Sup,Chen Chih-Kuang, and Yong Ken-Tye.Biodegradable nanocarriers for small interfering ribonucleic acid (siRNA) co-delivery strategy increase the chemosensitivity of pancreatic cancer cells to gemcitabine.Nano Research. 10(9): 3049–3067, 2017.  0

19.    Jiang Wenxiao, Natalia V. Beloglazova, Luo Pengjie§,Guo Ping, Lin Guimiao, and Xiaomei Wang*.A Dual-Color Quantum Dots Encoded Frit-Based Immunoassay for Visual Detection of Aflatoxin M1 and Pirlimycin Residues in Milk.J. Agric. Food Chem. 65:1822−1828, 2017.   1/1

20.    Wu Na, Zhang Zheng, Zhou Jie, Sun Zezhou, Deng Yueyue, Lin Guimiao, Ying Ming, Wang Xiaomei, Yong Ken-Tye, Wu Changfeng *, Xu Gaixia *. The biocompatibility studies of polymer dots on pregnant mice and fetuses. Nanotheranostics,2017,1(3):261-2710/0

21.    Jiang Wenxiao, Ross C.Beier, Luo Pengjie Zhai Peng, Wu Nan, Lin Guimiao, Wang Xiaomei*and Xu Gaixia. Analysis of Pirlimycin Residues in Beef Muscle,Milk,and Honey by a Biotin-Streptavidin-Amplified Enzyme-Linked Immunosorbert  Assay. 64:364-370, 2016.  3/7

22.    Wang YC, Yang CB, Hu R, Toh HT, Li X, Lin Guimiao, Yin F, Yoon HS, Yong KT. Assembling Mn:ZnSe quantum dots-siRNA nanoplexes for gene silencing in tumor cells. Biomaterials Science. 3(1):192-202, 2015.  7/9

23.    Yang CB, Hu R, Anderson T, Wang YC, Lin Guimiao, Law WC, rLin WJ, Nguyen QT, Toh HT, Yoon HS et al. Biodegradable nanoparticle-mediated K-ras down regulation for pancreatic cancer gene therapy. Journal of Materials Chemistry B. 3(10):2163-2172, 2015.  5/10

24.    Yin F, Zhang B, Zeng S, Lin Guimiao, Tian J, Yang C, Wang K, Xu G, Yong K. Folic acid-conjugated organically modified silica nanoparticles for enhanced targeted delivery in cancer cells and tumor in vivo. Journal of Materials Chemistry B. 3: 6081-6093, 2015.  9/10

25.    Yu F, Xie D, Ng SS, Lum CT, Cai M, Cheung WK, Kung H, Lin Guimiao, Wang X, Lin MC. IFITM1 promotes the metastasis of human colorectal cancer via CAV-1. Cancer Lett .368: 135-143, 2015.  10/10

26.    Liu X, Hu R, Lian H, Liu Y, Liu J, Liu J, Lin Guimiao, Liu L, Duan X, Yong K, Ye L. Dual-color immunofluorescent labeling with quantum dots of the diabetes-associated proteins aldose reductase and Toll-like receptor 4 in the kidneys of diabetic rats. International Journal of Nanomedicine. 10: 3651-3662, 2015.  0

27.    Liu X, Yang C, Liu J, Liu J, Hu R, Lian H, Lin Guimiao, Liu L, Yong K, Ye L. In Vitro evaluation and monitoring of the expression level and localization of aldose reductase using functionalized quantum dots and EGFP. Biotechnology and Bioprocess Engineering.20: 800-806, 2015.  0

28.    Yu F, Xie D, Ng SS, Lum CT, Cai M, Cheung WK, Kung H, Lin Guimiao, Wang X, Lin MC. IFITM1 promotes the metastasis of human colorectal cancer via CAV-1. Cancer Lett,2015, 368(1): 135-143.  10/10

29.    Hu Rui, Yang Chengbin, Wang Yucheng, Lin Guimiao, Qin Wei, Ouyang Qingling, Law Wing-Cheung, Nguyen Quoc Toan,  Yoon Ho Sup, Wang Xiaomei, Yong Ken-Tye, Tang Ben Zhong. Aggregation-induced emission (AIE) dye loaded polymer nanoparticles for gene silencing in pancreatic cancer and their in vitro and in vivo biocompatibility evaluation. Nano Research. 6:1-14, 2014.   10/13

30.    Hu SY, Zeng SW, Zhang BT, Yang CB, Song PY, Danny TJH, Lin Guimiao, Wang YC, Anderson T, Coquet P et al. Preparation of biofunctionalized quantum dots using microfluidic chips for bioimaging. Analyst. 139(18):4681-4690, 2014 . 6/12

31.    Liu Liwei, Hu Rui, Roy Indrajit, Lin Guimiao, Ye Ling, Reynolds Jessica L, Liu Jianwei, Liu Jing, Schwartz Stanley A, Zhang Xihe* and Yong Ken-Tye*. Synthesis of Luminescent Near-Infrared AgInS2 Nanocrystals as Optical Probes for In Vivo Applications. Theranostics. 3:109-115, 2013.  17/18

32.    Wang Yucheng, Hu Rui, Lin Guimiao, Roy Indrajit and Yong Ken-Tye*. Functionalized Quantum Dots for Biosensing and Bioimaging and Concerns on Toxicity. ACS Appl. Mater. Interfaces. 5: 2786−2799, 2013.  109/116

33.    Wang Yucheng, Hu Rui, LinGuimiao, Law Wing-Cheung, and Yong Ken-Tye *. Optimizing the aqueous phase synthesis of CdTe quantum dots using mixed-ligands system and their applications for imaging of live cancer cells and tumors in vivo. RSC Advances,2013, 3(23):8899-8908.  6/7

34.    Song Peiyi, Tng Danny Jian Hang, Hu Rui, Lin Guimiao, Meng Ellis and Yong Ken-Tye*. An Electrochemically Actuated MEMS Device for Individualized Drug Delivery: an In Vitro Study. Advanced Healthcare Materials. Adv. Healthcare Mater. 2: 1170–1178, 2013.  4/11

35.    Hu Rui, Wang Yucheng, Liu Xin, Lin Guimiao, Tan Cher Heng, Law Wing-Cheung, Roy Indrajit, and Yong Ken-Tye*. Rational design of multimodal and multifunctional InP quantum dot nanoprobes for cancer: in vitro and in vivo applications. RSC advances. 3: 8495-8503, 2013.  7/11

36.    Zhu XM, Wang XM, Zhai P, Feng G, Lin Guimiao, Chen Q, Mei SJ, Niu HB, Xu GX. Applications of Functionalized Quantum Dots in Tumor in vivo Imaging. Progress in Biochemistry and Biophysics. 40(10):963-970, 2013.  1/1

37.    Hu Rui, Law Wing-Cheung, Lin Guimiao, Ye Ling, Liu Jianwei, Liu Jing, Reynolds Jessica L. and Yong Ken-Tye*. PEGylated Phospholipid Micelle-Encapsulated Near-Infrared PbS Quantum Dots for in vitro and in vivo Bioimaging. Theranostics. 2:723-733, 2012.  26/36

38.    Lan Rongfeng, Lin Guimiao, Yin Feng, Xu Jun, Zhang Xiaoming, Wang Jing, Wang Yanchao, Gong Jianxian, Ding Yuan-Hua, Yang Zhen, Lu Fei and Zhang Hui*. Dissecting the Phenotypes of Plk1 Inhibition in Cancer Cells Using Novel Kinase Inhibitory Chemical CBB2001. Lab Invest. 92:1503-1514, 2012. 7/13

39.    Zhang Ling, Zhao LiJuan, Zhao Dan, Lin Guimiao, Guo BaoFeng, Li Yang, Liang Zuowen, Zhao Xuejian, Fang Xun*. Inhibition of Tumor Growth and Induction of Apoptosis in Prostate Cancer Cell Lines by Overexpression of Tissue Inhibitor of Matrix Metalloproteinase-3. Cancer Gene Ther. 17:171-179, 2010. 11/15

40.    Zhang Ling, Gao Lifang, Li Yang, Lin Guimiao, Shao Yueting, Ji Kun, Yu Hao, Hu Jiadi, Kalvakolanu Dhananjaya V, Kopecko Dennis J, Zhao Xuejian* and Xu De-Qi*. Effects of Plasmid-Based Stat3-Specific Short Hairpin RNA and GRIM-19 on PC-3M Tumor Cell Growth. Clin Cancer Res. 15: 559-568, 2008. 36/67