Name: Yingying Zhao

zhaoyingying@szu.edu.cn

2006-2012 Cornell University, Biomedical Science, Ph. D

2012-2014 Cornell University Weill Institute, Postdoc

2014-now Shenzhen University, assistant professor

My lab is interested in aging and neurodegenerative diseases, including:

1. ubiquitin modification mediated protein downregulation. Ubiquitin-proteasome system is a protein quality control system, it targets misfolded proteins for degradation. In the cytosol, specialized E3 ligases target soluble misfolded proteins for ubiquitination and subsequent proteasomal degradation. We study tissue specific E3 ligases and their substrates in normal and disease states. 
2. As the worldwide population ages, neurodegenerative diseases are becoming an increasingly important public health problem. We study Alzheimer’s disease especially the molecular basis of circadian clock dysfunction.  

Publications:

Shu XS, Zhao Y, Sun Y, Zhong L, Cheng Y, Zhang Y, Ning K, Tao Q, Wang Y, Ying Y. The epigenetic modifier PBRM1 restricts the basal activity of the innate immune system by repressing retinoic acid-inducible gene-I-like receptor signalling and is a potential prognostic biomarker for colon cancer. J Pathol. 2018 Jan;244(1):36-48. 

Zhao Y, Guan S, Song W, Li Y, Ling L, Wang Y, Li X, Qin L, Yu H, Yang H, Wang J, Yang J, Liu J, Cheng L. Relative abundance of β-thalassemia-related mutations in southern China correlates with geographical coordinates. Ann Hematol. 2017 Nov;96(11):1961-1963.

Zhang Y, Yuan Y, Liang P, Zhang Z, Guo X, Xia L, Zhao Y, Shu XS, Sun S, Ying Y, Cheng Y. Overexpression of a novel candidate oncogene KIF14 correlates with tumor progression and poor prognosis in prostate cancer. Oncotarget. 2017 Jul 11;8(28):45459-45469.

Lin G, Chen T, Zou J, Wang Y, Wang X, Li J, Huang Q, Fu Z, Zhao Y, Lin MC, Xu G, Yong KT. Quantum Dots-siRNA Nanoplexes for Gene Silencing in Central Nervous System Tumor Cells. Front Pharmacol. 2017 Apr 4;8:182. 

Zhao Y, Macgurn JA, Liu M, Emr S. The ART-Rsp5 ubiquitin ligase network comprises a plasma membrane quality control system that protects yeast cells from proteotoxic stress. Elife. 2013 Apr 16;2:e00459. 

Henne WM, Buchkovich NJ, Zhao Y, Emr SD. The endosomal sorting complex ESCRT-II mediates the assembly and architecture of ESCRT-III helices. Cell. 2012 Oct 12;151(2):356-71.