BIOGRAPHICAL SKETCH 　 　

NAME:  Lu, Xifeng 　 　

POSITION TITLE:  Assistant Professor 　 　

EDUCATION/TRAINING 　 　

A.  Personal Statement 　 　 　

My research interests are focused on three areas: 1) identifying novel E3 ligases that regulate key proteins involved in lipid metabolism and energy metabolism; 2) dissecting the role of the vacuolar H+-ATPase in lipid metabolism; and 3) searching for active components isolated from traditional Chinese medicines that could be used to treat metabolic diseases, such as non-alcoholic fatty liver disease (NAFLD), diabetes or dyslipidemia. 　 　   　

B.  Positions and Honors 　 　 　

Positions and Employment 　 　

11/2014 – present Assistant Professor, Shenzhen University, Shenzhen, China 　 　 　

C.  Peer-reviewed publications 　 　

1.  Liu, J., Liu, Y., Yan, Y., Yang, J., Lu, X. , Cheng, Y. Commiphoratones A and B, Two Sesquiterpene Dimers from Resina Commiphora. Organic Letters. In Press. (Co-corresponding author) 　 　

2.  Song, Y., Liu, Y., Yan, Y., Lu, X. , Cheng, Y. Phenolic Compounds from Belamcanda chinesis Seeds. Molecules. 2018.3.5. (Co-corresponding author) 　 　

3.  Ren, L., Sun Y., …, Ruan, X., Lu, X . (Pro)renin Receptor Inhibition Reprograms Hepatic Lipid Metabolism and Protects Mice from Diet-induced Obesity and Hepatsteatosis. Circ Res . 2018.3.2,122(5):730-741. (Co-corresponding author) 　 　

4.  Yang, X., Okamura, D., Lu, X. , Chen, Y., Moorhead, J., Varghese, Z., Ruan, X. CD36 in Chronic Kidney Disease: Novel Insights and Therapeutic Opportunities. Nature Reviews Nephrology. 2017. 12 ， 13(12):769 ： 781. 　 　

5.   Sun, Y., Danser, AHJ., Lu, X.  (Pro) renin Receptor as a Therapeutic Target for the treatment of Cardiovascular Diseases? Pharmacological Research .   2017.  7.125 ： 48-56. 　 　

6.  Zhu, X., Yan, Y., Ai, C., Jiang, S., Xu, S., Niu, M., Wang, X., Zhong, G., Lu, X. , Xue, Y., Tian, S., Li, G., Tang, S., Jiang., Y. Jarid2 is essential for the maintenance of tumor initiating cells in bladder cancer. Oncotarget. 2017. 11; 8(15): 24483–24490. 　 　

7.  Chen, D., Zhu, X., Yan, Y., Ai, C., Lu, X.,  Xu, S., Jiang, S., Zhong, G., Chen, D., Jiang., Y. Long Non-coding RNA HoxA-AS3 interacts with EZH2 to Regulate Lineage Commitment of Mesenchymal Stem Cells. Oncotarget. 2016. 7(39):63561-63570 　 　

8.  Daryadel, A., Bourgeois, S., Figueiredo, MF., Gomes Moreira, A., Kampik, NB., Oberli, L., Mohebbi, N., Lu, X. , Meima, ME., Danser, AH., and Wagner, CA., Colocalization of the (Pro)renin Receptor/Atp6ap2 with H+-ATPases in Mouse Kidney but Prorenin Does Not Acutely Regulate Intercalated Cell H ⁺ -ATPase Activity. PLoS One. ,   11(1):e0147831. 　 　

9.  Lu, X. , Meima, M., et al., Identification of the (Pro)renin receptor as a Novel Regulator of Lipoprotein Metabolism. Circ Res . 2016. 118(2):222-9. 　 　

10.  Lu, X. , Krop, M., et al., Renin inhibitor VTP-27999 differs from aliskiren: focus on their intracellular accumulation and the (pro)renin receptor. J Hypertens , 2014.  32(6):1255-63.   　 　

11.  Lu, X ., L.C. Roksnoer, and A.H. Danser, The intrarenal renin-angiotensin system: does it exist? Implications from a recent study in renal angiotensin-converting enzyme knockout mice. Nephrol Dial Transplant , 2013. 28(12): p. 2977-82. 　 　

12.  Persson, F*., Lu X *  et al., Urinary renin and angiotensinogen in type 2 diabetes: added value beyond urinary albumin? J Hypertens , 2013. 31(8): p. 1646-52. *: Joint first authors. 　 　

13.  Lu, X .,  et al., (Pro)renin receptor is required for prorenin-dependent and -independent regulation of vacuolar H(+)-ATPase activity in MDCK.C11 collecting duct cells. Am J Physiol Renal Physiol , 2013. 305(3): p. F417-25. 　 　

14.  Krop, M., Lu X , et al., New renin inhibitor VTP-27999 alters renin immunoreactivity and does not unfold prorenin. Hypertension , 2013. 61(5): p. 1075-82. 　 　

15.  Krop, M., Lu X , et al., The (pro)renin receptor. A decade of research: what have we learned? Pflugers Arch , 2013. 465(1): p. 87-97. 　 　

16.  Batenburg, W.W., Lu X , et al., Renin- and prorenin-induced effects in rat vascular smooth muscle cells overexpressing the human (pro)renin receptor: does (pro)renin-(pro)renin receptor interaction actually occur? Hypertension , 2011. 58(6): p. 1111-9. 　 　

17.  Lu, X ., A.H. Danser, and M.E. Meima, HRP and prorenin: focus on the (pro)renin receptor and vacuolar H ⁺ -ATPase. Front Biosci (Schol Ed) , 2011. 3: p. 1205-15. 　 　

D.  Research Support 　 　

National Natural Science Foundation of China  (No.81500667) 01/01/20 16  to 12/31/20 18 　 　

Xifeng Lu, PI ￥ 186 ,000 (direct cost) 　 　

The key role of the (pro)renin receptor in regulating LDL receptor function: a novel mechanism of plasma lipid regulation