BIOGRAPHICAL SKETCH 　 　

NAME: Mao, Zhuo 　 　

POSITION TITLE: Lecturer ,  Medical Center,  Shenzhen University School of Medicine 　 　

EDUCATION/TRAINING 　 　

A.  Personal Statement 　 　

My long-standing research interests focus on the role of gastrointestinal hormones on metabolic disorders, such as obesity, type 2 diabetes and fatty liver disease. I am also interested in  the bio logical function s  of zinc and zinc transporters in cellular and phy s iolog ical  processes. 　 　 　 　

B.  Positions and Honors 　 　

Positions and Employment 　 　

0 9 / 2005 –  08 / 2007 Resident, Department of Ob/Gyn , Peking University 1 ^st   Hospital, Beijing , China 　 　

0 1 /20 13  – 0 8 /201 4 Research associate, Department of Life Science, Hong Kong University of Science and Technology ,  Hong Kong, China 　 　

0 9 /201 4  – present Lecturer, Medical center,   Shenzhen University School of Medicine , Shenzhen, China 　 　

C.  Research Support 　 　   　

Ongoing Research Support 　 　

NSFC (China) youth  project (81500619 ) 01/01/20 16  to 12/31/20 18 　 　

Zhuo Mao , PI ￥ 180 ,000 (direct cost) 　 　

Mechanism of ZnT8 in the fatty liver of high fat diet fed mice 　 　

Guangdong NSFC project (2016A030310040 ) 06 /0 1 /20 18  to 06 / 0 1/20 19 　 　

Zhuo Mao , PI ￥ 1 00 ,000 (direct cost) 　 　

Differential regulation of gastrointestinal hormones ghrelin and nesfatin-1 　 　

Shenzhen Science and Technology Innovation Commission grant (JCYJ20160422091658982) 07/01/20 1 6  to 06/30/20 18 　 　

Zhuo Mao , PI ￥ 30 0,000 　 　

The role of ZnT8 in heaptic glucolipid metabolism 　 　 　 　

D.  Peer-reviewed publications (*: corresponding author) 　 　

1.  Cao M, Mao Z , Kam C, Xiao N, Cao X, Shen C, Cheng KK, Xu A, Lee KM, Jiang L and Xia J, PICK1 and ICA69 control insulin granule trafficking and their deficiencies lead to impaired glucose tolerance. Plos Biology, 2013; 11(4):e1001541. (Co-first author) 　 　

2.  Zhuo Mao  and Weizhen Zhang. Neuroendocrine Control of Hepatic Gluconeogenesis, in Gluconeogenesis, W. Zhang, Editor. 2017, InTech: Rijeka. p. Ch. 04. 　 　

3.  Zhuo Mao, Jinghui Li, Weizhen Zhang. Hormonal regulation of cholesterol homeostasis, in Cholesterol. (In press) 　 　

4.  Jia Li, Zhuo Mao , Jiandong Huang, Jun Xia. PICK1 is Essential for Insulin Production and the Maintenance of Glucose Homeostasis. Molecular Biology of the Cell. 2018 　 　

5.  Yangyang Yu, Zhenhe Huang, Zhuo Mao, Yarui Zhang, Meiling Jin, Wenwen Chen, Wei Zhang, Bo Yu, Weizhen Zhang, Hang Yung Alaster Yu. Go is required for the release of IL-8 and TNF-alpha, but not degranulation in human mast cells. Eur J Pharmacol, 2016. 780: p. 115-21. 　 　

6.  Meiling Jin, Bo Yu, Weizhen Zhang, Wei Zhang, Zhanggang Xiao, Zhuo Mao  , Yihong Lai, Dongxu Lin, Qiang Ma, En Pan, Yarui Zhang, Yangyang Yu. Toll-like receptor 2-mediated MAPKs and NF-kappaB activation requires the GNAO1-dependent pathway in human mast cells. Integr Biol (Camb), 2016. 8(9): p. 968-75. 　 　

7.    Li X, Mao Z , Wu M and Xia J, Rescuing infertility of PICK1 knockout mice by generating testis-specific transgenic mice via testicular infection. Scientific Report, 2013 Oct 8; 3:2842. 　 　

8.  Yang X, Li YZ, Mao Z , Gu P and Shang M, Effects of estrogen and tibolone on bladder histology and estrogen receptors in rats. Chinese Medicine Journal (English version), 2009, Feb 20; 122(4):381-5. 　 　

9.  Yang X, Mao Z , The mechanism s and treatments of female anal incontinence. Chinese Journal of Practical Gynecology and Obstetrics , 2006.638-640