BIOGRAPHICAL SKETCH 　 　

NAME: Sun , Jie 　 　

POSITION TITLE : Lecturer  of Health Science Center Institute of Medical Science , School of Medicine , Shenzhen University 　 　

EDUCATION/TRAINING 　 　

A.  Personal Statement 　 　

My research interests  focus on  molecular tumor pharmacology , saliva diagnosis research , metabolic nuclear receptors and lipid science . I have published > 10  papers in the peer-reviewed professional journals. 　 　

B.  Positions and Honors 　 　

Positions and Employment 　 　

0 9 / 2013 –   1 2 / 201 4 Visiting Scholar , School of Dentistry, University of California, Los Angeles ,   C A, USA 　 　

0 7 /201 5  – present       Lecturer, School of Medicine , Shenzhen University, Shenzhen, China 　 　   　

Organizing International Meetings 　 　

1.  Organizer, ISN Forefronts Symposium 2015 - Immunomodulation of Cardio-Renal Function, Oct. 22-25, 2015, Shenzhen, China 　 　

Other Experience and Honors 　 　

1.  S cientific R esearch A ward (first prize), Shenzhen University , 2016 　 　

2.  Excellent Paper   A ward (second prize), School of Medicine , Shenzhen University , 2016 　 　

3.  S cientific R esearch A ward (third prize), Shenzhen University , 2017 　 　

4.  Excellent Paper   A ward (third prize), School of Medicine , Shenzhen University , 2017 　 　

C.  Contributions to Science  (*: corresponding/co-corresponding author) 　 　

A full list of my publications (in a total of 12 ) is enclosed at the end of this document. 　 　

1.  M olecular T umor P harmacology 　 　

1)  Jie Sun ,   Fanni Li, Yue Zhao, Li Zhao, Chen Qiao, Zhiyu Li, Qinglong Guo*, Na Lu*. LZ-207, a newly synthesized flavonoid, induces apoptosis and suppresses inflammation-related colon cancer by inhibiting the NF-κB signaling pathway in vitro. PloS One , 2015 , 10(5): e0127282 　 　

2)  Jing Yao, Rong Hu (co-first), Jie Sun , Biqi Lin, Li Zhao, Yunying Sha, Binbin Zhu, Qi-Dong You, Yulin Wu, Qing-Long Guo*. Oroxylin A prevents inflammation-related tumor through down-regulation of inflammatory gene expression by inhibiting NF-κB signaling. Molecular Carcinogenesis , 2014 , 53(2):145-58 　 　

3)  Jing Yao, Di Pan, Yue Zhao, Li Zhao, Jie Sun , Yu Wang, Qi-Dong You, Tao Xi*, Qing-Long Guo*, Na Lu*. Wogonin prevents lipopolysaccharide-induced acute lung injury and inflammation in mice via peroxisome proliferator-activated receptor gamma-mediated attenuation of the nuclear factor-kappaB pathway. Immunology , 2014 , 143(2): 241~257 　 　

2.  S aliva D iagnosis R esearch 　 　

1)  Feng Li, Karolina Elzbieta Kaczor-Urbanowicz, Jie Sun , Blanca Majem, Hsien-Chun Lo, Yong Kim, Kikuye Koyano, Shannon Liu Rao ,  So Young Kang,   Su Mi Kim, Kyoung-Mee Kim, Sung Kim, David Chia, David Elashoff, Tristan R. Grogan, Xinshu Xiao, and David T.W. Wong * . Characterization of human salivary extracellular RNA (exRNA) by next-generation sequencing . Clinical Chemistry , 2018 , In press   　 　

2)  Yong Zhang, Jie Sun , Feng Li, Tristan R. Grogan, Jose L. Vergara, QingXian Luan, Moon-Soo Park, David Chia, David Elashoff, Kaumudi J. Joshipura * , David T.W. Wong * . Salivary Extracellular RNA biomarkers for Insulin Resistance Detection in Hispanics, Diabetes research and clinical practice , 2017 , 132: 85-94 　 　

3)  Blanca Majem, Feng Li, Jie Sun , David T.W. Wong * . RNA sequencing analysis of salivary extracellular RNA, Methods in Molecular Biology: Oral Biology (Springer) , 2016 , 1537:17-36 　 　

4)  Yong Zhang, Jie Sun (co-first) , Chien-Chung Lin, Elliot Abemayor, Marilene B. Wang, David T.W. Wong. The emerging landscape of salivary diagnostics, Periodontology 2000 , 2015 , 70(1):38-52 　 　

5)   Louise C. Laurent * , Asim Abdel­Mageed, Leonora Balaj, Xandra Breakefield, Elizabeth Carlson, Bob Carter, Blanca Majem Cavaller, Clark C. Chen, Emanuele Cocucci, Kristy Danielson, Amanda Courtright, Saumya Das, ZakaraiaAbd Elmageed, Daniel Enderle, Alan Ezrin, Marc Ferrer, Jane Freedman, David Galas, Roopali Gandhi, Kendall Jensen, Yong Kim, Anna M. Krichevsky, Madhu Lal ­Nag, Clara D. Laurent, Trevor Leonardo, Feng Li, Ivana Malenica, Debasis Mondal, Parham Nejad, Tushar Patel, Robert Raffai, Renee Rubio, Johan Skog, Jie Sun , Kahraman Tanriverdi, Kasey C. Vickers, Liang Wang, Yaoyu Wang, Zhiyun Wei, Howard L. Weiner, David Wong, Irene Yan, Ashish Yeri, Stephen Gould. Meeting report: discussions and preliminary findings on extracellular RNA measurement methods from laboratories in the NIH Extracellular RNA Communication Consortium. Journal of Extracellular Vesicles , 2015 ,4:10.3402/jev.v4.26533 　 　

3.  M etabolic N uclear R eceptor and L ipid S cience 　 　

1)  Li wei Ren, Yuan Sun, Hong Lu, Dien Ye, Lijuan Han, Na Wang, Alan Daugherty, Furong Li, Miaomiao Wang, Fengting Su, Wenjun Tao, Jie Sun , Noam Zelcer, Adam E Mullick, AH J Danser, Yizhou Jiang, Yongcheng He, Xiongzhong Ruan * , Xifeng Lu * . (Pro)renin Receptor Inhibition Reprograms Hepatic Lipid Metabolism and Protects Mice from Diet-Induced Obesity and Hepatosteatosis. Circulation research , 2018 , 122(4) 　 　

2)  Jie Sun , Xiaolin Zhang, Xiongzhong Ruan. Immunity, atherogenesis and vascular function, Experimental Physiology , 2016 , 101(11): 1325~1326 　 　

D.  Research Support 　 　

Ongoing Research Support 　 　

Shenzhen University New Teacher Scientific Research Start-Up Fund ( 2016086 ) 0 6 /01/20 16  to 05 /31/20 18 　 　

Jie Sun , PI    ￥6 0,000 (direct cost) 　 　

S creening, verification and mechanism of exRNA biomarkers for early diagnosis of chronic kidney disease 　 　 　 　

NSFC  (China) Youth   Fund   ( 31701022 ) 01/01/20 18  to 12/31/20 20 　 　

Jie Sun , Participant ￥ 26 0 ,000 (direct cost) 　 　

M echanism of CD36 polymorphism in renal tubular lipid damage 　 　 　 　

Completed Research Support 　 　

NSFC (China) Fund ( 81372268 ) 0 1 /01/20 14  to 12 /31/20 17 　 　

Jie Sun , Participant ￥730 ,000 (direct cost) 　 　

M echanism of Nrf2 negative regulation of NLRP3 inflammasome and its role in the chemoprophylaxis of inflammatory related tumors 　 　 　 　

NSFC  (China) Youth   Fund ( 81202611 ) 0 1 /01/20 13  to 12 /3 1 /20 15 　 　

Jie Sun , Participant ￥ 23 0,000   (direct cost) 　 　

M echanism of regulating Wnt signaling pathway to reverse the drug resistance of brain glioma stem cells 　 　

E.  Peer-reviewed publications (*: corresponding author) 　 　

1.  Feng Li, Karolina Elzbieta Kaczor-Urbanowicz, Jie Sun , Blanca Majem, Hsien-Chun Lo, Yong Kim, Kikuye Koyano, Shannon Liu Rao ,  So Young Kang,   Su Mi Kim, Kyoung-Mee Kim, Sung Kim, David Chia, David Elashoff, Tristan R. Grogan, Xinshu Xiao, and David T.W. Wong * . Characterization of human salivary extracellular RNA (exRNA) by next-generation sequencing . Clinical Chemistry , 2018 , In press 　 　

2.  Li wei Ren, Yuan Sun, Hong Lu, Dien Ye, Lijuan Han, Na Wang, Alan Daugherty, Furong Li, Miaomiao Wang, Fengting Su, Wenjun Tao, Jie Sun , Noam Zelcer, Adam E Mullick, AH J Danser, Yizhou Jiang, Yongcheng He, Xiongzhong Ruan * , Xifeng Lu * . (Pro)renin Receptor Inhibition Reprograms Hepatic Lipid Metabolism and Protects Mice from Diet-Induced Obesity and Hepatosteatosis. Circulation research , 2018 , 122(4) 　 　

3.  Yong Zhang, Jie Sun , Feng Li, Tristan R. Grogan, Jose L. Vergara, QingXian Luan, Moon-Soo Park, David Chia, David Elashoff, Kaumudi J. Joshipura * , David T.W. Wong * . Salivary Extracellular RNA biomarkers for Insulin Resistance Detection in Hispanics, Diabetes research and clinical practice , 2017 , 132: 85-94 　 　

4.  Blanca Majem, Feng Li, Jie Sun , David T.W. Wong * . RNA sequencing analysis of salivary extracellular RNA, Methods in Molecular Biology: Oral Biology (Springer) , 2016 , 1537:17-36 　 　

5.  Jie Sun , Xiaolin Zhang, Xiongzhong Ruan. Immunity, atherogenesis and vascular function, Experimental Physiology , 2016 , 101(11): 1325~1326 　 　

6.  Yong Zhang, Jie Sun (co-first) , Chien-Chung Lin, Elliot Abemayor, Marilene B. Wang, David T.W. Wong. The emerging landscape of salivary diagnostics, Periodontology 2000 , 2015 , 70(1):38-52 　 　

7.  Louise C. Laurent * , Asim Abdel­Mageed, Leonora Balaj, Xandra Breakefield, Elizabeth Carlson,   Bob Carter, Blanca Majem Cavaller, Clark C. Chen, Emanuele Cocucci, Kristy Danielson, Amanda Courtright, Saumya Das, ZakaraiaAbd Elmageed, Daniel Enderle, Alan Ezrin, Marc Ferrer, Jane Freedman, David Galas, Roopali Gandhi, Kendall Jensen, Yong Kim, Anna M. Krichevsky, Madhu Lal ­Nag, Clara D. Laurent, Trevor Leonardo, Feng Li, Ivana Malenica, Debasis Mondal, Parham Nejad, Tushar Patel, Robert Raffai, Renee Rubio, Johan Skog, Jie Sun , Kahraman Tanriverdi, Kasey C. Vickers, Liang Wang, Yaoyu Wang, Zhiyun Wei, Howard L. Weiner, David Wong, Irene Yan, Ashish Yeri, Stephen Gould. Meeting report: discussions and preliminary findings on extracellular RNA measurement methods from laboratories in the NIH Extracellular RNA Communication Consortium. Journal of Extracellular Vesicles , 2015 ,4:10.3402/jev.v4.26533 　 　

8.  Jie Sun , Fanni Li, Yue Zhao, Li Zhao, Chen Qiao, Zhiyu Li, Qinglong Guo * , Na Lu * . LZ-207, a newly synthesized flavonoid, induces apoptosis and suppresses inflammation-related colon cancer by inhibiting the NF-κB signaling pathway in vitro. PloS One , 2015 , 10(5): e0127282 　 　

9.  Jing Yao, Rong Hu (co-first), Jie Sun , Biqi Lin, Li Zhao, Yunying Sha, Binbin Zhu, Qi-Dong You, Yulin Wu, Qing-Long Guo * . Oroxylin A prevents inflammation-related tumor through down-regulation of inflammatory gene expression by inhibiting NF-κB signaling. Molecular Carcinogenesis , 2014 , 53(2):145-58 　 　

10.  Jing Yao, Di Pan, Yue Zhao, Li Zhao, Jie Sun , Yu Wang, Qi-Dong You, Tao Xi * , Qing-Long Guo * , Na Lu * . Wogonin prevents lipopolysaccharide-induced acute lung injury and inflammation in mice via peroxisome proliferator-activated receptor gamma-mediated attenuation of the nuclear factor-kappaB pathway. Immunology ,  2014 , 143(2): 241~257 　 　

11.  Yong Zhang, Jie Sun  (co-first), Chien-Chung Lin, Elliot Abemayor, Marilene B. Wang, David T.W. Wong * . The emerging landscape of salivary diagnostics.  Oral Health Dent Manag , 2014 , 13(2): 200-10 　 　

12.  Tingting Zhang, Siwei Yang(co-first), Jie Sun , Xiubing Li, Ling He, Shuai Yan, Xingyuan Kang, Chenshu Hu, Fang Liao * . Poly(p-phenylenediamine) fluorescent nanosphere: A ultra-sensitive fluorescent probe for caffeine. Synthetic Metals ,  2013 , 181, 86-91