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常港

常港 副教授

生物化学与分子生物学系

基础医学院

changgang@szu.edu.cn 

生殖细胞发育机制与再生

常港，副教授，特聘研究员，博士生导师。2009年毕业于中国科学院动物研究所/北京生命科学研究所获博士学位。

常港博士长期致力于生殖细胞发育与再生领域的研究工作，以通讯作者/第一作者（含共同）在Nature Cell Biology、Cell Stem Cell、Cell Research、Nature Communications（2篇）、Science Advances等国际主流刊物发表研究论文30余篇，累计影响因子超过200。荣获2009年中国科学院优秀毕业生。深圳市后备级领军人才、南山区领航人才。主持国家重点研发计划课题1项、国自然面上项目3项、广东省科技计划项目2项、深圳市基础研究重点项目1项、深圳市医学专项资金一般项目1项、深圳市基础研究面上项目2项。担任Nucleic Acids Research、Stem Cell Res Ther、Fundamental Research等多个国际知名杂志的特约审稿人。

研究项目：

  1. 国家重点研发计划课题，2024.12-2029.12，主持

  2. 国家自然科学基金面上项目，2024.01-2027.12，主持

  3. 国家自然科学基金面上项目，2022.01 -2025.12，主持

  4. 国家自然科学基金面上项目，2020.01 -2023.12，主持

  5. 深圳市医学研究专项资金一般项目，2025.01 -2027.12，主持

  6. 深圳市基础研究重点项目，2021.08 -2024.07，主持

代表性论文：

1. Huang YP＃, Li L＃, An G＃, Yang XY＃, Cui MM＃, Song XL, Lin J, Zhang XL, Yao ZK, Wan C, Zhou C, Zhao JX, Song K, Ren SF, Xia XY, Fu X, Lan Y, Hu XS, Wang W, Wang M, Zheng Y, Miao K, Bai XC, Andrew P Hutchins, Chang G*, Gao S*, Zhao XY*. (2023). Single-cell multi-omics sequencing of human spermatogenesis reveals a DNA demethylation event associated with male meiotic recombination. Nature Cell Biology. 25(10):1520-1534.

2. Wang J＃, Zhou C＃, Gao S＃, Song XL＃, Yang XY＃, Fan JQ, Ren SF, Ma LZ, Zhao JX, Cui MM, Song K, Wang M, Li CH, Zheng Y, Luo F, Miao K, Bai XC,Andrew P Hutchins, Li L*, Chang G*, Zhao XY*. (2022).Single-cell multi-omics sequencing reveals the reprogramming defects in embryos generated by round spermatid injection. Science Advances 12;8(32):eabm3976.

3.Zhao J＃, Lu P＃, Wan C＃, Huang Y＃, Cui M, Yang X, Hu Y, Zheng Y, Dong J, Wang M, Zhang S, Liu Z, Bian S, Wang X, Wang R, Ren S, Wang D, Yao Z, Chang G*, Tang F*, Zhao XY*. (2021). Cell-fate transition and determination analysis of mouse male germ cells throughout development. Nature Communications12(1):6839.

4. Wang X＃, Veerapandian V＃, Yang X＃, Song K＃, Xu X, Cui M, Yuan W, Huang Y, Xia X, Yao Z, Wan C, Luo F, Song X, Wang X, Zheng Y, Hutchins AP, Jauch R, Liang M, Wang C, Liu Z*, Chang G＃*, Zhao XY*. (2021). The chromatin accessibility landscape reveals distinct transcriptional regulation in the generation of human primordial germ cell-like cells from pluripotent stem cells. Stem Cell Reports 16(5):1245-1261.

5. Wang M＃, Liu X＃, Chang G＃, Chen Y＃, An G＃, Yan L, Gao S, Xu Y, Cui Y, Dong J, Chen Y, Fan X, Hu Y, Song K, Zhu X, Gao Y, Yao Z, Bian S, Hou Y, Lu J, Wang R, Fan Y, Lian Y, Tang W, Wang Y, Liu J, Zhao L, Wang L, Liu Z, Yuan R, Shi Y, Hu B, Ren X, Tang F*, Zhao XY*, Qiao J*. (2018). Single-Cell RNA sequencing analysis reveals sequential cell fate transition during human spermatogenesis. Cell Stem Cell 23(4):599-614.

6. Gao S＃, Hou X＃, Jiang Y, Xu Z, Cai T, Chen J*, Chang G*. (2017). Integrated analysis of hematopoietic differentiation outcomes and molecular characterization reveals unbiased differentiation capacity and minor transcriptional memory in HPC/HSC-iPSCs. Stem Cell Res Ther 8:13.

7. Gao S＃, Tao L, Hou X, Xu Z, Liu W, Zhao K, Guo M, Wang H, Cai T, Tian J, Gao S, Chang G*. (2016). Genome-wide gene expression analyses reveal unique cellular characteristics related to the amenability of HPC/HSCs into high-quality induced pluripotent stem cells. Stem Cell Res Ther 7:40.

8. Gao S＃, Zheng C＃, Chang G＃, Liu W, Kou X, Tan K, Tao L, Xu K, Wang H, Cai J, Tian J*, Gao S*. (2015). Unique features of mutations revealed by sequentially reprogrammed induced pluripotent stem cells. Nature Communications 6, 6318.

9. Chang G＃, Gao S＃, Hou X, Xu Z, Liu Y, Kang L, Tao Y, Liu W, Huang B, Kou X, Chen J, An L, Miao K, Di K, Wang Z, Tan K, Cheng T, Cai T, Gao S*, Tian J*. (2014). High-throughput sequencing reveals the disruption of methylation of imprinted gene in induced pluripotent stem cells. Cell Research 24, 293-306.

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