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【医学部学术讲座】--Understanding Biological Recognition of Nanoparticles – En Route to A New Generation of Vaccines

文章来源: 作者: 发布时间:2019年03月05日 点击数: 字体:

主讲嘉宾: Yan Yan 教授

   间: 201936日上午10:00-11:00

   点:深圳大学西丽校区A2-517会议室

    要:

Biomolecules adsorbed on nanoparticles are known to confer a biological identity to nanoparticles, mediating the interactions with cells and biological barriers. Recently, there have been significant developments in understanding molecular details of the bio-molecular corona, moving from macroscopic to microscopic, primarily based on the immune-mapping technique. However, how these molecules presented on the particle surface are connected with the biological recognition in complex biological milieu remains unclear. To address it, we will present our recent work focusing on the development of a robust in vitro platform to allow direct identification of specific nanoparticle-receptor interactions. In this presentation, we will give several examples of probing and connecting the nanoparticle surface properties to their biological recognition using the in vitro platform. We envisage that a purpose-built receptor library approach for validating nanoparticle-receptor interactions will facilitate to unravel complex biological processes in vivo.

主讲嘉宾简介:

Dr. Yan Yan is an Assistant Professor in Biochemistry in School of Biomolecular and Biomedical Science at University College Dublin (UCD). She received her PhD in Biochemistry and Molecular Biology from Peking University, China. Afterwards Dr. Yan pursued her postdoctoral training on targeted drug delivery in oncology at University of Melbourne, Australia, and worked as a research fellow at University of Melbourne before joining UCD in 2015.

Dr. Yan now is leading a research group in understanding how nanoscale interactions can be used to reconstruct immune response with the aim of developing immune-therapies. Dr. Yan has been a recipient of several prestigious fellowships and awards, including 2017 the 1st place of outstanding early career investigator team presentation at Interstellar Initiative awarded by the New York Academy of Science and Japan Agency for Medical Research and Development, 2016 Science Foundation Ireland Starting Investigator Research Award, 2013 Australia Research Council Discovery Early Career Research Award, and 2013 Australian Eureka Prize for Excellence in Interdisciplinary Scientific Research. She has co-authored over 50 publications in high profile journals.

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