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讲师

赵滢滢

 

 

 

姓名:赵滢滢

邮箱:zhaoyingying@szu.edu.cn

 

 

简介:赵滢滢,深圳大学医学部讲师,副研究员。2012年获美国康奈尔大学生物医学博士,专业医学生理学,师从美国科学院院士Scott Emr. 2012至2014年美国康奈尔大学Weill研究所从事博士后工作。2014年7月加入深圳大学医学部基础医学院生理学系,先后获深圳市海外高层次人才(孔雀计划C类),南山区领航人才,深圳市高层次人才。主持并完成国家自然科学青年基金1项,广东省自然科学基金1项,深圳市基础研究等项目3项,多篇论文发表在有影响力的国际期刊。长期从事衰老相关研究,重点关注衰老相关时间生物学,利用多组学、脑电波及核磁共振等方法研究大脑功能(生物节律),以及物理刺激(光,声,磁场等)对生物节律的影响等。

 

研究方向:

(1)下丘脑生物节律。

(2)睡眠障碍、阿尔兹海默症等多种衰老疾病中生物节律的变化及对疾病的影响

 

科研项目:

1. 深圳市自由探索项目: 靶向period基因逆转阿尔兹海默病生物节律紊乱的研究,在研, 50万

2. 深圳市自由探索项目:恒定旋转磁场缓解多发性硬化并减轻脊髓炎性浸润的分子机制研究,在研,30万

2. 广东省自然科学基金:低频旋恒磁场对卵母细胞发育成熟影响及其机制研究,结题,10万 

3.国家自然科学基金:核受体LXRβ对肾脏集合管上皮水通道蛋白AQP2的调节机制,结题, 24万

4. 深圳市海外高层次人才科研启动,结题,270万 

 

 

发表文章:

Yao Y, Ying Y, Deng Q, Zhang W, Zhu H, Lin Z, Zhang S, Ma J, Zhao Y. Non-invasive 40-Hz Light Flicker Ameliorates Alzheimer's-Associated Rhythm Disorder via Regulating Central Circadian Clock in Mice. Front Physiol 3.201. 2020 Apr 24;11:294. (共同通讯)

Zhan T, Wang X, Ouyang Z, Yao Y, Xu J, Liu S, Liu K, Deng Q, Wang Y, Zhao Y. Rotating magnetic field ameliorates experimental autoimmune encephalomyelitis by promoting T cell peripheral accumulation and regulating the balance of Treg and Th1/Th17. Aging (Albany NY) 2020 Apr 7;12. (共同通讯)

Yao Y, Zhang W, Ming R, Deng Q, Zuo A, Zhang S, Ying Y, Zhao Y*, Ma J. Noninvasive 40-Hz Light Flicker Rescues Circadian Behavior and Abnormal Lipid Metabolism Induced by Acute Ethanol Exposure via Improving SIRT1 and the Circadian Clock in the Liver-Brain Axis. Front Pharmacol. 2020 Mar 25;11:355. (共同通讯)

Zhao Y, Zhu H, Yang Y, Ye Y, Yao Y, Huang X, Zhang Y, Shu X, Chen X, Yang Y, Ma J, Cheng L, Wang X, Ying Y.AQP1 suppression by ATF4 triggers trabecular meshwork tissue remodelling in ET-1-induced POAG. Journal of cellular and molecular medicine.2020 Feb 13. 

Wang Y#, Zuo A#, Huang X, Ying Y, Shu X, Chen X, Yang Y, Ma J, Lin G, Wang X, Mei L, Liu G, Zhao Y*. Docetaxel-Loaded PAMAM-Based Poly (γ-benzyl-L-glutamate)-b- D -α - Tocopheryl Polyethylene Glycol 1000 Succinate Nanoparticles in Human Breast Cancer And Human Cervical Cancer therapy. J Microencapsul. 2019 Aug 12:1-33. (通讯作者)

Shu X#, Zhang Y, Li M, Huang X, Yang Y, Zeng J, Zhao Y, Wang X, Zhang W*, Ying Y*. Topical ocular administration of the GLP-1 receptor agonist liraglutide arrests hyperphosphorylated tau-triggered diabetic retinal neurodegeneration via activation of GLP-1R/Akt/GSK3β signaling. Neuropharmacology. 2019 Jul 15;153:1-12.

Guan S#, Zhao Y#, Zhuo X, Song W, Geng X, Yang H, Wang J, Wu X, Yang J, Song X, Cheng L*.Regional gender differences in an autosomal disease result in corresponding diversity differences. Sci Rep4.011. 2019 Apr 2;9(1):5472. (并列一作)

Zhu H, Zhang W, Zhao Y, Shu X, Wang W, Wang D, Yang Y, He Z, Wang X, Ying Y*. GSK3β-mediated tau hyperphosphorylation triggers diabetic retinal neurodegeneration by disrupting synaptic and mitochondrial functions. Mol Neurodegener. 2018 Nov 22;13(1):62.  (并列一作)

Yahalom V, Pillar N, Zhao Y, Modan S, Fang M, Yosephi L, Asher O, Shinar E, Celniker G, Resnik-Wolf H, Brantz Y, Hauschner H, Rosenberg N, Cheng L, Shomron N, Pras E. SMYD1 is the underlying gene for the AnWj-negative blood group phenotype. Eur J Haematol. 2018 Oct;101(4):496-501.

Shu X#, Wang D#, Zhao Y#, Sun Y, Hu X, Huang X, Zeng J, Li C, Li Y, Zeng Y, Wang X, He Z, Ying Y. Extract from Moringa oleifera seeds suppresses the epithelial-mesenchymal transition-mediated metastasis of gastric cancer by targeting the metastatic suppressor NDRG1 Extract from Moringa oleifera seeds suppresses the epithelial-mesenchymal transition-mediated metastasis of gastric cancer by targeting the metastatic suppressor NDRG1. Journal of functional foods 50(2018)93-103  (并列一作)

Zhao Y#, Guan S#, Song W, Li Y, Ling L, Wang Y, Li X, Qin L, Yu H, Yang H, Wang J, Yang J, Liu J, Cheng L.Relative abundance of β-thalassemia-related mutations in southern China correlates with geographical coordinates. Ann Hematol. 2017 Nov;96(11):1961-1963. (并列一作)

Lin G, Chen T, Zou J, Wang Y, Wang X, Li J, Huang Q, Fu Z, Zhao Y, Lin MC, Xu G, Yong KT. Quantum Dots-siRNA Nanoplexes for Gene Silencing in Central Nervous System Tumor Cells. Front Pharmacol. 2017 Apr 4;8:182.

Zhao Y#, Macgurn JA#, Liu M, Emr S*. The ART-Rsp5 ubiquitin ligase network comprises a plasma membrane quality control system that protects yeast cells from proteotoxic stress. Elife. 2013 Apr 16;2:e00459.  (并列一作)

Henne WM#, Buchkovich NJ#, Zhao Y, Emr SD*.The endosomal sorting complex ESCRT-II mediates the assembly and architecture of ESCRT-III helices. Cell. 2012 Oct 12;151(2):356-71.