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讲师

王中原

 

姓名:王中原

职位:讲师 硕士生导师

邮箱:wangzhongyuan@szu.edu.cn

 

2007年6月于吉林大学获理学学士学位,2010年6月于吉林大学获理学硕士学位,2014年于清华大学获理学博士学位,随后进入深圳大学医学部基础医学院担任讲师工作。目前主要从事肿瘤的分子与细胞生物学机理以及抗肿瘤药物研究。主要研究Hippo信号通路、Wnt信号通路在肿瘤发生、发展、和转移中的作用机制,以及开发针对Hippo信号通路、Wnt信号通路的抗肿瘤药物,取得了一些科研成果。在国际著名期刊Proc Natl Acad Sci U S A等发表论文10余篇,单篇最高引用次数190余次。

 

研究方向

1. Hippo信号通路、Wnt信号通路在肿瘤发生、发展、和转移中的作用机制;

2. 开发针对Hippo信号通路、Wnt信号通路的抗肿瘤药物。

 

科研项目

1. 主持项目

1. 国家自然科学基金面上项目,31870754,CK1δ/ε介导的AES的降解调控结直肠癌转移和干性的机制研究,2019.01-2022.12,主持。(在研)

2. 国家自然科学基金青年项目,31501143,盐霉素调控乳腺癌细胞Hippo信号通路的研究,2016.01-2018.12,主持。(已结题)

3. 广东省自然科学基金博士启动项目,2014A030310168,低氧通过调控Hippo信号通路来促进乳腺癌转移的研究,2015.01-2017.01,主持。(已结题)

4. 深圳市基础研究项目,JCYJ20150525092941030,盐霉素调控乳腺癌细胞Hippo信号通路的研究,2015.11-2017.10,主持。(已结题)

 

代表性成果论文(#第一作者,*表示通讯作者)

1.Zhongyuan Wang#, Liang Zhou#, Yanpeng Xiong, Shubin Yu, Huan Li, Jiaoyang Fan, Fan Li, Zijie Su, Jiaxing Song, Qi Sun, Shan-Shan Liu, Yuqing Xia, Liang Zhao, Shiyue Li, Fang Guo, Peng Huang, Dennis A. Carson*, and Desheng Lu*. Salinomycin exerts anti-colorectal cancer activity by targeting the β-catenin/TCF complex. Br J Pharmacol, 2019,176(17):3390-3406.

2.Zijie Su#, Jiaxing Song#, Zhongyuan Wang#, Liang Zhou, Yuqing Xia, Shubin Yu, Qi Sun, Shan-shan Liu, Liang Zhao, Shiyue Li, Lei Wei, Dennis A. Carson*, Desheng Lu*. Tumor promoter TPA activates Wnt/β-catenin signaling in a casein kinase 1-dependent manner. Proc Natl Acad Sci U S A, 2018, 115(32): E7522-E7531.

3.Zhongyuan Wang#, Bo Li#, Liang Zhou, Shubin Yu, Zijie Su, Jiaxing Song, Qi Sun,a Ou Sha, Xiaomei Wang, Wenqi Jiang, Karl Willert, Lei Wei, Dennis A. Carson*, Desheng Lu*. Prodigiosin inhibits Wnt/β-catenin signaling and exerts anticancer activity in breast cancer cells. Proc Natl Acad Sci U S A, 2016, 113(46): 13150-13155.

4.Zhongyuan Wang#, Yanping Wu#, Haifeng Wang, Yangqing Zhang, Lin Mei, Xuexun Fang, Xudong Zhang, Fang Zhang, Hongbo Chen, Ying Liu, Yuyang Jiang, Shengnan Sun, Yi Zheng, Na Li, Laiqiang Huang*. Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility. Proc Natl Acad Sci U S A, 2014, 111(1): E89-98. (Selected as Editors’ Choice of Science Signaling)

5.Shubin Yu#, Zhongyuan Wang#, Zijie Su, Jiaxing Song, Liang Zhou, Qi Sun, Shanshan Liu, Shiyue Li, Ying Li, Meina Wang, Guo-Qiang Zhang, Xue Zhang, Zhong-Jian Liu*, Desheng Lu*. Gigantol inhibits Wnt/β-catenin signaling and exhibits anticancer activity in breast cancer cells. BMC Complement Altern Med, 2018, 18(1): 59-66.

6.Hongling Zhang#, Gan Liu#, Xiaowei Zeng, Yanping Wu, Chengming Yang, Lin Mei, Zhongyuan Wang*, Laiqiang Huang*. Fabrication of genistein-loaded biodegradable TPGS-b-PCL nanoparticles for improved therapeutic effects in cervical cancer cells. Int J Nanomedicine. 2015, 10: 2461-2473.

7.Yanping Wu#, Zhongyuan Wang#, Gan Liu #, Xiaowei Zeng, Xusheng Wang, Yongfeng Gao, Lijuan Jiang, Xiaojun Shi, Wei Tao, Laiqiang Huang*, Lin Mei*. Novel Simvastatin-Loaded Nanoparticles Based on Cholic Acid-Core Star-Shaped PLGA for Breast Cancer Treatment. J Biomed Nanotechnol, 2015, 11(7): 1247-1260.

8.Zhongyuan Wang#, Yanping Wu#, Xiaowei Zeng#, Yaping Ma, Jian Liu, Xiaolong Tang, Yongfeng Gao, Kewei Liu, Jinxie Zhang, Pinghong Ming, Laiqiang Huang*, Lin Mei*. Antitumor efficiency of D-alpha-tocopheryl polyethylene glycol 1000 succinate-b-poly(epsilon-caprolactone-ran-lactide) nanoparticle-based delivery of docetaxel in mice bearing cervical cancer. J Biomed Nanotechnol, 2014, 10(8): 1509-1519.

9.Zhongyuan Wang#, Na Li#, Yanyan Wan, Yanping Wu, Tianyang Mu, Yi Zheng, Laiqiang Huang*, Xuexun Fang*. Ubiquitin-intein and SUMO2-intein fusion systems for enhanced protein production and purification. Protein Expr Purif, 2012, 82(1): 174-178. (Recommended by “Faculty of 1000”)

10.Zhongyuan Wang, Haolong Li, Wei Guan, Haili Ling, Zhiyong Wang, Tianyang Mu, Franklin Shuler, Xuexun Fang*. Human SUMOfusion systems enhance protein expression and solubility. Protein Expr Purif, 2010, 73(2): 203-208.