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讲师

刘文娟

 

姓名:刘文娟

邮箱:lwj0320@szu.edu.cn

简介:

2010年获南方医科大学博士学位,后在香港大学李嘉诚医学院生理学系和心内科工作;2012年进入深圳大学医学院工作。从事心肌肥大,心肌梗死等心血管疾病模型下心肌细胞和成纤维细胞离子通道功能的改变及其发生机理的研究。在国际著名期刊Circulation、Hypertension、J Mol Cell Cardiol、Free Radical Biology & Medcine、AJP等发表11余篇论文;主持国家自然科学基金青年项目1项,广东省教育厅青年创新项目1项,孔雀启动项目1项,深圳大学教师启动基金1项,项目经费总额500余万元。

 

研究方向

(1)正常与疾病心脏离子通道和钙信号的调节

(2)心肌肥大等心脏疾病的发病机制

 

主持科研项目

1.国家自然科学基金青年项目, HMGB1引起心肌细胞肌浆网钙漏流的作用和机制及其在缺血-再灌注心脏损伤中的作用,2015/01-2017/12,项目负责人

2.广东省教育厅青年创新人才项目, TRIM72在疾病心脏心律失常发生中的作用及其分子机制的研究,2015/01-2017/12,项目负责人

3.深圳市基础研究项目, MG53在疾病心脏心律失常发生中的作用及作为心律失常治疗新靶点的研究,2015/01-2016/12,项目负责人

 

代表性成果

1)Liu W, Wang G, Zhang C, Ding W, Cheng W, Luo Y, Wei C, Liu J*. MG53, a novel regulator of KChIP2 and Ito,f, plays a critical role in electrophysiological remodeling in cardiac hypertrophy. Circulation. 2019Feb14.doi: 10.1161/CIRCULATIONAHA.118.029413.

2)Santosh Kumar#, Wang G #, Liu WJ #, Ding WW, Dong M, Zheng N, Ye HY, Liu J*. Hypoxia-Induced Mitogenic Factor Promotes Cardiac Hypertrophy via Calcium-Dependent and Hypoxia-Inducible Factor-1α Mechanisms. Hypertension. 2018;72(2):331-342.

3)Liu WJ#, Chen PY#, Deng JX, Lv JZ, Liu J*. Resveratrol and polydatin as modulators of Ca2+ mobilization in the cardiovascular system. Ann N.Y. Acad Sci 2017;1403: 82–91.

4)Liu WJ#, Deng JX#, Wang G, Gao KP, Lin ZX, Liu SY, Wang YH, Liu J*. Manipulation of KCNE2 expression modulates action potential duration and Ito and IK in rat and mouse ventricular myocytes. Am J Physiol Heart Circ Physiol 2015; 309(8):H1288-302.

5)Liu WJ#, Deng JX#, Wang G#, Zhang C, Luo X, Yan D, Su Q, Liu J*.  KCNE2 modulates cardiac L-type Ca2+ channel. J Mol Cell Cardiol 2014;72:208-18.

6)Jiang X#, Liu WJ#, Deng JX#, Lan LQ, Xue X, Zhang CC, Cai GR, Luo XP, Liu J*. Polydatin protects cardiac function against burn injury by inhibiting sarcoplasmic reticulum Ca2+ leak through reducing oxidative modification of ryanodine receptors. Free Radic BiolMed 2013;60:292-9.

7)Deng JX, Liu WJ#, Wang YR, Dong M, Zheng M, Liu J. Polydatin modulates Ca2+ handling, excitation-contraction coupling and b-adrenergic signaling in rat ventricular myocytes. J Mol Cell Cardiol, 2012 Nov;53(5):646-56.

8)Chen JB, Liu WJ#, Che H, Liu J, Sun HY, Li GR. Adenosine-5'-triphosphate Up-regulates Proliferation in Cultured Human Cardiac Fibroblasts. Br J Pharmacol. 2012 Jun;166(3): 1140-50.

9)Liu W, Deng J, Xu J, Wang H, Yuan M, Liu N, Jiang Y, Liu J*. High-mobility group box 1 (HMGB1) downregulates cardiac transient outward potassium current (Ito) through downregulation of Kv4.2 and Kv4.3 channel transcripts and proteins. J Mol Cell Cardiol, Sep 2010; 49(3): 438-48.

10)Liu W, Wang H, Chen W, Deng J, Jiang Y, Liu J*. Co-expression of KCNE2 and KChIP2c modulates the electrophysiological properties of Kv4.2 current in COS-7 cells. Acta Pharmacologica Sinica 2008; 29(6):653-660.

11)He ML, Liu WJ, Sun HY, Wu W, Liu J, Tse HF, Lau CP, Li GR. Effects of ion channels on proliferation in cultured human cardiac fibroblasts. J Mol Cell Cardiol, 2011 Aug; 51(2): 198-206.

 

获得学术奖励

1)刘文娟(2/6), 正常与疾病心脏兴奋-收缩偶联调节机制的研究, 广东省人民政府, 自然科学奖, 三等奖, 2017