副教授

应颖

 

应颖,博士,副教授,硕士研究生导师。2003年获英国伦敦学院大学(UCL)分子医学硕士学位,2007年获德国海德堡大学分子生物学博士学位。2008-2010获香港中文大学博士后研究基金资助,于香港中文大学医学院从事博士后研究工作。2010年9月作为留学回国人员被引进加入深圳大学医学院生理学教研室,2011年晋升副教授。2013年获深圳市海外高层次人才(B类)。长期从事代谢性疾病及肿瘤的发病机制及干预研究,主持国家自然科学基金2项,广东省高教厅优秀青年创新项目1项,深圳市基础研究项目多项。

办公电话: 0755-86671931

Email: yingying@szu.edu.cn

 

研究方向

(1)糖尿病及其并发症、神经退行性疾病发生发展的分子机制。

(2)消化道肿瘤转录及表观遗传调控异常的机制研究。

 

科研项目

1. 主持项目

1)国家自然科学基金面上项目:14-3-3ζ介导CDK5和GSK3β促tau蛋白过度磷酸化:糖尿病早期视网膜神经节细胞变性的新机制(81670760)2017年1-2020年12

2)国家自然科学基金青年基金:“GLP-1/beta-catenin/TCF信号通路对糖尿病鼠心肌细胞凋亡的保护作用与机制研究”(81200602)2013年1-2015年12

3)广东省高教厅科研项目,Syntabulin介导cAMP促进胰岛素分泌的作用(2012LYM_0119)2012年12月-2014年12月

4)深圳市基础研究项目:“Tau蛋白异常磷酸化对糖尿病视网膜病变的早期预警及靶向干预研究” (JCYJ20170818143305472)2018年4月-2020年3月

5)深圳市基础研究项目:具类胰岛素效应的氧钒配合物抗糖尿病早期视网膜神经退行性病变的作用机制研究JCYJ201604220915236122017年1-2018年12

6)深圳市基础研究项目:“AMPK(腺苷酸活化蛋白激酶)/mTOR(雷帕霉素靶蛋白)介导的自噬在糖尿病大鼠早期视网膜神经病变中的作用研究(JCYJ201404180914135502015年1-2016年12

 

发表论文

1. Huazhang Zhu#, Weizhen Zhang#, Yingying Zhao#, Xing-sheng Shu#, Wencong Wang, Dandan Wang, Yangfan Yang, Zhijun He, Xiaomei Wang, Ying Ying*. GSK3β-mediated tau hyperphosphorylation triggers diabetic retinal neurodegeneration by disrupting synaptic and mitochondrial functions. Mol Neurodegeneration 2018;13(1):62.

2. Xingsheng Shu#, Yilin Zhang#, Meiqi Li, Xiaoyan Huang, Yangfan Yang, Junhui Zeng, Yingying Zhao, Xiaomei Wang, Weizhen Zhang, Ying Ying*. Topical ocular administration of the GLP-1 receptor agonist liraglutide arrests hyperphosphorylated tau-triggered diabetic retinal neurodegeneration via activation of GLP-1R/Akt/GSK3β signaling. Neuropharmacolocy,2019;153:1-12.

3. Ying Ying,* Yi-lin Zhang,* Can-jie Ma, Mei-qi Li, Chao-yue Tang, Yang-fan Yang, Jun-hui Zeng, Xiao-yan Huang, Junbo Yi, Xiao-mei Wang, Zhen-dan He, Xing-sheng Shu*. Neuroprotective effects of ginsenoside Rg1 against hyperphosphorylated tau-induced diabetic retinal neurodegeneration via activation of IRS-1/Akt/GSK3β signaling. Journal of Agriculture and Food Chemistry 2019; 67:8348-8360.

4. Xing-sheng Shu*, Yingying Zhao, Yanmei Sun, Lan Zhong, Yingduan Cheng, Yixiang Zhang, Kaile Ning, Qian Tao, Yejun Wang*, Ying Ying*. PBRM1 restricts the basal activity of the innate immune system by repressing retinoic acid-inducible gene-I-like receptor signalling and is a potential prognostic biomarker for colon cancer. Journal of Pathology 2018;244(1):36-48.

5. Xing-sheng Shu,# Dan-dan Wang,# Ying-ying Zhao,# Yan-mei Sun, Xiao-peng Hu, Xiao-yan Huang, Jun-hui Zeng, Chen-yang Li, Yan Li, Yong Zeng, Xiao-mei Wang, Zhen-dan He,* and Ying Ying*. Extract from Moringa oleifera seeds suppresses the epithelial-mesenchymal transition-mediated metastasis of gastric cancer by targeting the metastatic suppressor NDRG1. Journal of Functional Foods. 2018;50:93–103.

6. Yixiang Zhang#, Yeqing Yuan#, Pei Liang#, Zhaoxia Zhang, Xiaojing Guo, Ligang Xia, Yingying Zhao, Xing-sheng Shu, Shengkun Sun, Ying Ying*, Yingduan Cheng*. Overexpression of a novel candidate oncogene KIF14 correlates with tumor progression and poor prognosis in prostate cancer.  Oncotarget 2017, 8(28): 45459-45469.

7. Dandan Wang#Huazhang Zhu#Shiwei LiJiaming YangYang XiaoQiangrong KangChenyang LiYunshi ZhaoYong ZengYan LiJian ZhangZhendan He*, Ying Ying*. Crude Saponins of Panax notoginseng Have Neuroprotective Effects To Inhibit Palmitate-Triggered Endoplasmic Reticulum Stress-Associated Apoptosis and Loss of Postsynaptic Proteins in Staurosporine Differentiated RGC-5 Retinal Ganglion Cells. Journal of Agriculture and Food Chemistry 2016647):1528-1539.

8.  Ying Ying#*Huazhang Zhu#Zhen LiangXiaosong Ma, Shiwei Li. GLP1 protects cardiomyocytes from palmitate-induced apoptosis via Akt/GSK3b/b-catenin pathway. Journal of Molecular Endocrinology 2015553):245-262.

9.  Ying YingLingyun LiWen CaoDan YanQing ZengXiangcheng KongLina LuYang MenXiaohui XuJunle QuQingning Su* Xiaosong Ma*. The microtubule associated protein syntabulin is required for glucose-stimulated and cAMP-potentiated insulin secretion. FEBS Letters 201258620):3674-3680.

10. Matthias Naumer#Ying Ying#Stefan MichelfelderAntje Reuter, Matin TrepelOliver J. Müller, Jürgen A. Kleinschmidt*. Development and validation of novel AAV2 random libraries displaying peptides of diverse lengths and at diverse capsid positions. Human Gene Therapy 2012235):492-507.

11.  Ying Ying#Oliver J. Müller# Caroline Goehringer,Barbara LeuchsMartin TrepelHugo A. KatusJA Kleinschmidt*. Heart-targeted adeno-associated viral vectors selected by in vivo biopanning of a random viral display peptide library. Gene Therapy 2010178):980-990.

12.  Ying Ying#Qian Tao*. Epigenetic disruption of the WNT/β-catenin signaling pathway in human cancers. Epigenetics 200945):307-312.

13.Yan Cui#Ying Ying#Andrew van HasseltKa Man NgJun YuZhangJie JinDingxie LiuJohng S. RhimSun Young RhaMyriam LoyoAnthony T. C. ChanGopesh SrivastavaGeorge S. W. TsaoGrant C. SellarJoseph J. Y.Sung, David Sidransky*Qian Tao*. OPCML is a broad tumor suppressor for multiple carcinomas and lymphomas with frequently epigenetic inactivation. PLos One  2008, 38):e2990.