深医讲座论坛

【生医学术讲座】--Redox-Responsive Polycondensate Neoepitope for Enhanced Personalized Cancer Vaccine

文章来源: 作者: 发布时间:2019年12月02日 点击数: 字体:

 

 Redox-Responsive Polycondensate Neoepitope for Enhanced Personalized Cancer Vaccine

主讲嘉宾:Li Tang教授

    间:2019124日下午14:30-17:00

    点:深圳大学西丽校区A2-517会议室

    要:

A versatile and highly effective platform remains a major challenge in the development of personalized cancer vaccines. We devised a redox-responsive polycondensate neoepitope (PNE) through a reversible polycondensation reaction of peptide neoantigens and adjuvants together with a tracelessly responsive linker-monomer. Peptide-based neoantigens with diverse sequences and structures could be co-polymerized with molecular adjuvants to form PNEs of high loading capacity for vaccine delivery without adding any carriers. The redox-responsive PNEs with controlled molecular weights and sizes efficiently targeted and accumulated in draining lymph nodes, and greatly promoted the antigen capture and cross-presentation by professional antigen presenting cells. Mice immunized with PNEs showed markedly enhanced antigen-specific T cell response and the protective immunity against the tumor cell challenge. I will also discuss our recent discovery of a new immunotherapy that reinvigorates terminally exhausted tumor infiltrating lymphocytes leading to eradication of a majority of treated solid tumors and durable cures in mouse models.

 

主讲嘉宾简介:

Li Tang received his B.S. in Chemistry from Peking University in China in 2007, and his Ph.D. in Materials Science and Engineering from University of Illinois at Urbana-Champaign, USA, in 2012, under the supervision of Prof. Jianjun Cheng. He was an Irvington Postdoctoral Fellow in the laboratory of Prof. Darrell Irvine at Massachusetts Institute of Technology during 2013-2016. He joined the faculty of Institute of Bioengineering, and Institute of Materials Science & Engineering, at École polytechnique fédérale de Lausanne (EPFL), Lausanne, Switzerland, as a Professor in 2016. His research focuses on modulating the immune system using smart biomaterials to develop novel vaccines and immunotherapies. Dr. Tang is the recipient of 2018 European Research Council (ERC) starting grant, Nano Research Young Innovator Award (NR 45 under 45 in the world), and Irvington Postdoctoral Fellowship from Cancer Research Institute.

 

【打印文章】 【添加收藏】